Nature Search

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts

Accumulations of R-loops can lead to genome instability. Here the authors reveal a role for the MRN complex in suppressing R-loops and associated DNA damage at transcription–replication conflicts.

Emily Yun-Chia Chang
Shuhe Tsai
Peter C. Stirling
ResearchOpen Access19 Sept 2019
Nature Communications

Volume: 10, P: 1-15
Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8

The meiotic proteins Spo11 and Rec8, which ensure meiotic recombination and reductional chromosome segregation, have additional activities that challenge centromere stability by promoting centromeric nucleosome remodelling in both fission yeast and human cells.

Haitong Hou
Eftychia Kyriacou
Julia Promisel Cooper
Research03 Mar 2021
Nature

Volume: 591, P: 671-676
Author Correction: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome

Marc Janier
Mohammed Almadjub
Madhuri Warren
Amendments and Corrections15 Feb 2022
Nature Genetics

Volume: 54, P: 358-360
Addressing the safety of next-generation batteries

Next-generation batteries will present different risks to conventional lithium-ion cells, emphasizing the need for efforts towards characterizing the abuse tolerance and hazards associated with next-generation battery materials over their life cycle and providing the data in the context of supporting affected professionals.

Chuanbo Yang
Avtar Singh
Donal P. Finegan
Reviews17 Sept 2025
Nature

Volume: 645, P: 603-613
Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome

Mutations in genes affecting intraflagellar transport account for some but not all cases of short rib polydactyly syndromes. Here Taylor et al. use whole exome sequencing and in vivo cell line assays to identify novel disease associated mutations in DYNC2LI1.

S. Paige Taylor
Tiago J. Dantas
Deborah Krakow
Research16 Jun 2015
Nature Communications

Volume: 6, P: 1-11
Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing

Precise chromosome segregation during mitosis requires coordination of stable chromosome bi-orientation with anaphase onset, however the underlying mechanism is not clear. Here the authors show that inner centromere localization of the chromosomal passenger complex maintains centromeric cohesion on bi-oriented chromosomes and allows mitotic checkpoint silencing.

Rutger C. C. Hengeveld
Martijn J. M. Vromans
Susanne M. A. Lens
ResearchOpen Access31 May 2017
Nature Communications

Volume: 8, P: 1-12
Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3

The authors show that loss-of-interaction with the nuclear importer, TNPO3, causes cytoplasmic mislocalization of RBM20 variants linked to severe cases of dilated cardiomyopathy. Restoring their nuclear localization alleviates the disease phenotype.

Julia Kornienko
Marta Rodríguez-Martínez
Lars M. Steinmetz
ResearchOpen Access18 Jul 2023
Nature Communications

Volume: 14, P: 1-20
A Hec of a microtubule attachment

The central function of kinetochores is to grasp a dynamic microtubule. Structural, biochemical and cell biological approaches have converged to uncover a microtubule-binding activity within the Ndc80/HEC1 complex, providing a satisfying answer to a question that has puzzled biologists for the last century.

Michael Emanuele
Daniel J Burke
P Todd Stukenberg
News & Views01 Jan 2007
Nature Structural & Molecular Biology

Volume: 14, P: 11-13
Australian experience of a modified schedule of FOLFOX with high activity and tolerability and improved convenience in untreated metastatic colorectal cancer patients

D Goldstein
P Mitchell
S Clarke
ResearchOpen Access01 Mar 2005
British Journal of Cancer

Volume: 92, P: 832-837
Novel gene function revealed by mouse mutagenesis screens for models of age-related disease

Random mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute to specific mutations revealed by whole-genome sequencing.

Paul K. Potter
Michael R. Bowl
Steve D. M. Brown
ResearchOpen Access18 Aug 2016
Nature Communications

Volume: 7, P: 1-13
One thousand plant transcriptomes and the phylogenomics of green plants

The One Thousand Plant Transcriptomes Initiative provides a robust phylogenomic framework for examining green plant evolution that comprises the transcriptomes and genomes of diverse species of green plants.

James H. Leebens-Mack
Michael S. Barker
Gane Ka-Shu Wong
ResearchOpen Access23 Oct 2019
Nature

Volume: 574, P: 679-685
Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1

Chloroquine resistance in Plasmodium falciparum is characterized using population genomics, genetic crosses and gene editing.

Alfred Amambua-Ngwa
Katrina A. Button-Simons
Timothy J. C. Anderson
ResearchOpen Access11 May 2023
Nature Microbiology

Volume: 8, P: 1213-1226
A genome-wide association study identifies multiple loci for variation in human ear morphology

The shape of the pinna varies widely in the general human population but the genetic basis of this variation is unknown. Here Adhikari et al. conduct a genome-wide association study in Latin Americans and discover seven gene regions influencing pinna morphology, including EDAR and TBX15.

Kaustubh Adhikari
Guillermo Reales
Andrés Ruiz-Linares
ResearchOpen Access24 Jun 2015
Nature Communications

Volume: 6, P: 1-10
A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance

Inactivating mutations in a protein kinase, NEK10, cause a genetic bronchiectasis syndrome in humans that is characterized by short motile cilia and impaired mucociliary transport.

Raghu R. Chivukula
Daniel T. Montoro
David M. Sabatini
Research20 Jan 2020
Nature Medicine

Volume: 26, P: 244-251
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

RNA polymerase II with a hypophosphorylated C-terminal domain preferentially incorporates into mediator condensates, and with a hyperphosphorylated C-terminal domain into splicing-factor condensates, revealing phosphorylation as a regulatory mechanism in condensate preference.

Yang Eric Guo
John C. Manteiga
Richard A. Young
Research07 Aug 2019
Nature

Volume: 572, P: 543-548
A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation

Humans show great diversity in facial appearance and this variation is highly heritable. Here, Andres Ruiz-Linares and colleagues examined facial features in admixed Latin Americans and identify genome-wide associations for 14 facial traits, including four gene loci (RUNX2, GLI3, DCHS2 and PAX1) influencing nose morphology.

Kaustubh Adhikari
Macarena Fuentes-Guajardo
Andrés Ruiz-Linares
ResearchOpen Access19 May 2016
Nature Communications

Volume: 7, P: 1-11
Circadian and circatidal clocks control the mechanism of semilunar foraging behaviour

James F. Cheeseman
Rachel M. Fewster
Michael M. Walker
ResearchOpen Access19 Jun 2017
Scientific Reports

Volume: 7, P: 1-7
Evaluation of the economic impact of modified screening criteria for retinopathy of prematurity from the Postnatal Growth and ROP (G-ROP) study

John A. F. Zupancic
Gui-shuang Ying
Gui-shuang Ying
Research28 Feb 2020
Journal of Perinatology

Volume: 40, P: 1100-1108
Plasmodium falciparum genetic crosses in a humanized mouse model

A human-liver chimeric mouse supports the growth of recombinant Plasmodium falciparum progeny, enabling easy analysis of genetic crosses between parasite strains.

Ashley M Vaughan
Richard S Pinapati
Stefan H I Kappe
Research01 Jun 2015
Nature Methods

Volume: 12, P: 631-633
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

Polo-like kinase-1 (PLK1) is an essential mitotic kinase regulating multiple aspects of the cell division process. Activation of PLK1 is shown to occur before mitosis and to depend on phosphorylation by aurora-A kinase, facilitated by a cofactor Bora. The initial activation of PLK1 seems to be a primary function of aurora-A.

Libor Macůrek
Arne Lindqvist
René H. Medema
Research09 Jul 2008
Nature

Volume: 455, P: 119-123
The power and promise of genetic mapping from Plasmodium falciparum crosses utilizing human liver-chimeric mice

Button-Simons et al. report on two different genetic crosses of Plasmodium falciparum derived from Asian and African origin parasites, and generate large numbers of recombinant progeny. These crosses are characterized and have the potential to map biologically important traits across parasite genomes.

Katrina A. Button-Simons
Sudhir Kumar
Ian H. Cheeseman
ResearchOpen Access14 Jun 2021
Communications Biology

Volume: 4, P: 1-13
Antipathogenic properties and applications of low-dimensional materials

Antimicrobial resistance is a growing global problem and low dimensional materials have emerged as a potential solution. Here, the authors review the progress which has been made on low dimensional antimicrobials looking at the materials synthesis, modes of action and currently applications.

Z. L. Shaw
Sruthi Kuriakose
Sumeet Walia
ReviewsOpen Access23 Jun 2021
Nature Communications

Volume: 12, P: 1-19
A panel of optimized primers and positive-control DNAs for PCR detection of common biological contaminants in mouse cell lines and tissue samples

Anne-Marie Ayral
Sarah Clarkson
T. Neil Dear
Research01 Sept 2006
Lab Animal

Volume: 35, P: 31-36
Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model

Apoorva Mulay
Derek W. Hood
Colin D. Bingle
ResearchOpen Access15 Feb 2018
Scientific Reports

Volume: 8, P: 1-12
Pooled genetic perturbation screens with image-based phenotypes

In this protocol, CRISPR perturbations are introduced in cells using lentiviral libraries and read out using in situ sequencing, coupling high-throughput pooled screening with phenotypic image readouts in live or fixed cells.

David Feldman
Luke Funk
Paul C. Blainey
Protocols12 Jan 2022
Nature Protocols

Volume: 17, P: 476-512

Search

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts

Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8

Author Correction: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome

Addressing the safety of next-generation batteries

Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome

Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing

Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3

A Hec of a microtubule attachment

Australian experience of a modified schedule of FOLFOX with high activity and tolerability and improved convenience in untreated metastatic colorectal cancer patients

Novel gene function revealed by mouse mutagenesis screens for models of age-related disease

One thousand plant transcriptomes and the phylogenomics of green plants

Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1

A genome-wide association study identifies multiple loci for variation in human ear morphology

A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation

Circadian and circatidal clocks control the mechanism of semilunar foraging behaviour

Evaluation of the economic impact of modified screening criteria for retinopathy of prematurity from the Postnatal Growth and ROP (G-ROP) study

Plasmodium falciparum genetic crosses in a humanized mouse model

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

The power and promise of genetic mapping from Plasmodium falciparum crosses utilizing human liver-chimeric mice

Antipathogenic properties and applications of low-dimensional materials

A panel of optimized primers and positive-control DNAs for PCR detection of common biological contaminants in mouse cell lines and tissue samples

Loss of the homeostatic protein BPIFA1, leads to exacerbation of otitis media severity in the Junbo mouse model

Pooled genetic perturbation screens with image-based phenotypes

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