The Notch family of receptors activate a complex web of cancer-relevant signalling pathways, and activating mutations inNOTCH1are common drivers of T cell acute lymphoblastic leukaemia (T-ALL). Despite this oncogenic role of NOTCH1 in T-ALL, mutations in Notch genes are rare in solid cancers. This Review discusses the growing evidence that deregulation of Notch signalling can indeed have a major role in the development of various solid tumours, and the oncogenic versus tumour suppressive roles of Notch signalling are highly context dependent.
- Prathibha Ranganathan
- Kelly L. Weaver
- Anthony J. Capobianco
