Nature Search

Plasma proteomics links brain and immune system aging with healthspan and longevity

In a large-scale proteomic study of biological aging of 11 organs from 44,498 individuals in the UK Biobank, the biological ages of the brain and immune system emerged as strong predictors of healthspan and longevity.

Hamilton Se-Hwee Oh
Yann Le Guen
Tony Wyss-Coray
ResearchOpen Access09 Jul 2025
Nature Medicine

Volume: 31, P: 2703-2711
Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes

Genetic and environmental factors influence lifespan. Here, the authors analyse UK Biobank data to identify common and rare lifespan-associated variants, many of which are linked to cancer and clonal haematopoiesis.

Junyoung Park
Andrés Peña-Tauber
Yann Le Guen
ResearchOpen Access28 Feb 2025
Nature Communications

Volume: 16, P: 1-11
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary statistics from diverse populations.

Aude Nicolas
Richard Sherva
Jean-Charles Lambert
ResearchOpen Access18 Jun 2025
Nature Genetics

Volume: 57, P: 1598-1610
Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer’s disease

Proteogenomic analysis of human cerebrospinal fluid by measuring 6,361 proteins in 3,506 individuals identifies new protein QTLs and highlights genetic regulation involved in neurological processes.

Daniel Western
Jigyasha Timsina
Carlos Cruchaga
Research11 Nov 2024
Nature Genetics

Volume: 56, P: 2672-2684
Resting-state connectivity biomarkers define neurophysiological subtypes of depression

Using functional MRI in a large multisite sample of more that 1,000 patients, four distinct neurophysiological biotypes of depression are defined. These biotypes are used to develop diagnostic classifiers that distinguish patients with depression from controls in separate multisite validation and replication cohorts, and can predict patient responsiveness to therapy.

Andrew T Drysdale
Logan Grosenick
Conor Liston
Research05 Dec 2016
Nature Medicine

Volume: 23, P: 28-38
TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models

The role of TREM1 in neurodegenerative diseases is unclear. Here the authors show that TREM1 promotes cognitive decline in aging and in the context of amyloid pathology in a mouse model of Alzheimer disease.

Edward N. Wilson
Congcong Wang
Katrin I. Andreasson
Research27 Mar 2024
Nature Neuroscience

Volume: 27, P: 873-885
GhostKnockoff inference empowers identification of putative causal variants in genome-wide association studies

The authors present GhostKnockoff, a method for genome-wide association studies which can be applied to enhance existing and future studies to identify functional variants with weaker statistical effects that might be missed by conventional association tests.

Zihuai He
Linxi Liu
Iuliana Ionita-Laza
ResearchOpen Access23 Nov 2022
Nature Communications

Volume: 13, P: 1-16
regionalpcs improve discovery of DNA methylation associations with complex traits

Understanding gene-level methylation is key to studying diseases like Alzheimer’s disease. Here, the authors introduce regionalpcs, a method that improves sensitivity by analysing methylation patterns with principal components, revealing genes linked to Alzheimer’s disease risk.

Tiffany Eulalio
Min Woo Sun
Stephen B. Montgomery
ResearchOpen Access03 Jan 2025
Nature Communications

Volume: 16, P: 1-19
Organ aging signatures in the plasma proteome track health and disease

Blood plasma protein data was combined with machine learning models for a simple method to determine differences in organ-specific aging; the study provides a basis for the prediction of diseases and aging effects using plasma proteomics.

Hamilton Se-Hwee Oh
Jarod Rutledge
Tony Wyss-Coray
ResearchOpen Access06 Dec 2023
Nature

Volume: 624, P: 164-172
Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions

Sports-related concussion is increasingly recognized as a potential danger to paediatric populations, but its short-term and long-term consequences remain poorly understood. This Expert Consensus Document is the result of a 1-day meeting convened by Safe Kids Worldwide, the Alzheimer's Drug Discovery Foundation, and the Andrews Institute for Orthopaedics and Sports Medicine, with the aim of highlighting knowledge gaps and areas of critically needed research in youth sports-related concussion.

Aaron J. Carman
Rennie Ferguson
Howard M. Fillit
ReviewsOpen Access17 Mar 2015
Nature Reviews Neurology

Volume: 11, P: 230-244
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

An integrated analysis of several cohorts shows that clonal, antigen-experienced T cells are found in the cerebrospinal fluid of patients with Alzheimer’s disease, suggesting that the adaptive immune system has a role in age-related neurodegeneration.

David Gate
Naresha Saligrama
Tony Wyss-Coray
Research08 Jan 2020
Nature

Volume: 577, P: 399-404
Identification of putative causal loci in whole-genome sequencing data via knockoff statistics

Association analyses that capture rare and noncoding variants in whole genome sequencing data are limited by factors like statistical power. Here, the authors present KnockoffScreen, a statistical method using the knockoff framework to detect, localise and prioritise rare and common risk variants at genome-wide scale.

Zihuai He
Linxi Liu
Iuliana Ionita-Laza
ResearchOpen Access25 May 2021
Nature Communications

Volume: 12, P: 1-18
Author Correction: Rare genetic coding variants associated with human longevity and protection against age-related diseases

Jhih-Rong Lin
Patrick Sin-Chan
Zhengdong D. Zhang
Amendments and Corrections28 Aug 2024
Nature Aging

Volume: 4, P: 1328
Rare genetic coding variants associated with human longevity and protection against age-related diseases

In this whole-exome sequencing study of the largest centenarian cohort to date, Lin et al. demonstrate that conserved pathways—for example, IIS and AMPK signaling—are as relevant to human longevity and healthy aging as they are in worms, flies and mice.

Jhih-Rong Lin
Patrick Sin-Chan
Zhengdong D. Zhang
Research13 Sept 2021
Nature Aging

Volume: 1, P: 783-794
The connectomics of brain disorders

Pathological perturbations of the brain can be described and modelled using network science. In this Review, Fornito, Zalesky and Breakspear discuss adaptive and maladaptive neural responses to such insults and consider how connectomics can be used to map, track and predict disease progression.

Alex Fornito
Andrew Zalesky
Michael Breakspear
Reviews20 Feb 2015
Nature Reviews Neuroscience

Volume: 16, P: 159-172
Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease

Multistage gene burden analysis in exome sequencing data from 32,558 individuals identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease.

Henne Holstege
Marc Hulsman
Jean-Charles Lambert
ResearchOpen Access21 Nov 2022
Nature Genetics

Volume: 54, P: 1786-1794
Dissociable Effects of Antipsychotics on Ketamine-Induced Changes in Regional Oxygenation and Inter-Regional Coherence of Low Frequency Oxygen Fluctuations in the Rat

Jennifer Li
Keita Ishiwari
Gary Gilmour
Research20 Jan 2014
Neuropsychopharmacology

Volume: 39, P: 1635-1644
An open resource for transdiagnostic research in pediatric mental health and learning disorders

Lindsay M. Alexander
Jasmine Escalera
Michael P. Milham
ResearchOpen Access19 Dec 2017
Scientific Data

Volume: 4, P: 1-26
Common and Dissociable Dysfunction of the Reward System in Bipolar and Unipolar Depression

Theodore D Satterthwaite
Joseph W Kable
Daniel H Wolf
Research13 Mar 2015
Neuropsychopharmacology

Volume: 40, P: 2258-2268
Decoding the heterogeneity of Alzheimer’s disease diagnosis and progression using multilayer networks

Bárbara Avelar-Pereira
Michael E. Belloy
S. M. Hadi Hosseini
ResearchOpen Access20 Dec 2022
Molecular Psychiatry

Volume: 28, P: 2423-2432

Search

Plasma proteomics links brain and immune system aging with healthspan and longevity

Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes

Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer’s disease

Resting-state connectivity biomarkers define neurophysiological subtypes of depression

TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models

GhostKnockoff inference empowers identification of putative causal variants in genome-wide association studies

regionalpcs improve discovery of DNA methylation associations with complex traits

Organ aging signatures in the plasma proteome track health and disease

Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease

Identification of putative causal loci in whole-genome sequencing data via knockoff statistics

Author Correction: Rare genetic coding variants associated with human longevity and protection against age-related diseases

Rare genetic coding variants associated with human longevity and protection against age-related diseases

The connectomics of brain disorders

Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease

Dissociable Effects of Antipsychotics on Ketamine-Induced Changes in Regional Oxygenation and Inter-Regional Coherence of Low Frequency Oxygen Fluctuations in the Rat

An open resource for transdiagnostic research in pediatric mental health and learning disorders

Common and Dissociable Dysfunction of the Reward System in Bipolar and Unipolar Depression

Decoding the heterogeneity of Alzheimer’s disease diagnosis and progression using multilayer networks

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