Nature Search

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

Thorsten Heinzel
Robert M. Lavinsky
Michael G. Rosenfeld
Research01 May 1997
Nature

Volume: 387, P: 43-48
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients with COVID-19 both early and months after SARS-CoV-2 infection, particularly in those with brain dysfunction or neurological diagnoses.

Benedict D. Michael
Cordelia Dunai
David K. Menon
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Recurrent humid phases in Arabia over the past 8 million years

A climatic record from desert speleothems shows that the central Arabian interior experienced recurrent humid intervals over the past 8 million years, which likely facilitated mammalian dispersals between Africa and Eurasia.

Monika Markowska
Hubert B. Vonhof
Gerald H. Haug
ResearchOpen Access09 Apr 2025
Nature

Volume: 640, P: 954-961
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Erik Ingelsson and colleagues report a large-scale genome-wide meta-analysis for associations to the extremes of anthropometric traits, including body mass index, height, waist-to-hip ratio and clinical obesity. They identify four loci newly associated with height and seven loci newly associated with clinical obesity and find overlap in the genetic structure and distribution of variants identified for these extremes of the trait distributions and for the general population.

Sonja I Berndt
Stefan Gustafsson
Erik Ingelsson
Research07 Apr 2013
Nature Genetics

Volume: 45, P: 501-512
Phosphorylase kinase phosphorylates a brain protein which is influenced by repetitive synaptic activation

MICHAEL BROWNING
WILLIAM BENNETT
GARY LYNCH
Research15 Mar 1979
Nature

Volume: 278, P: 273-275
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Isidro Cortés-Ciriano
Jake June-Koo Lee
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 331-341
Comprehensive molecular characterization of mitochondrial genomes in human cancers

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

Yuan Yuan
Young Seok Ju
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 342-352
Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction

Gloria I. Perez
C. Michael Knudson
Jonathan L. Tilly
Research01 Nov 1997
Nature Medicine

Volume: 3, P: 1228-1232
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Sex differences in fasting glucose and insulin have been identified, but the genetic loci underlying these differences have not. Here, the authors perform a meta-analysis of genome-wide association studies to detect sex-specific and sex-dimorphic loci associated with fasting glucose and insulin.

Vasiliki Lagou
Reedik Mägi
Inga Prokopenko
ResearchOpen Access05 Jan 2021
Nature Communications

Volume: 12, P: 1-18
Crm-A, bcl-2 and NDGA inhibit CD95L-induced apoptosis of malignant glioma cells at the level of caspase 8 processing

Bettina Wagenknecht
Jörg B Schulz
Michael Weller
Research22 Oct 1998
Cell Death & Differentiation

Volume: 5, P: 894-900
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Cecilia Lindgren and colleagues report results of a large-scale genome-wide association study for waist-to-hip ratio, a measure of body fat distribution. They identify 13 new loci associated with this trait, several of which show stronger effects in women than in men.

Iris M Heid
Anne U Jackson
Cecilia M Lindgren
Research10 Oct 2010
Nature Genetics

Volume: 42, P: 949-960
Author Correction: Butler enables rapid cloud-based analysis of thousands of human genomes

Sergei Yakneen
Sebastian M. Waszak
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Biotechnology

Volume: 41, P: 577
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
A CCG expansion in ABCD3 causes oculopharyngodistal myopathy in individuals of European ancestry

A significant proportion of individuals with inherited neuromuscular disease do not receive a genetic diagnosis. Here, the authors establish CCG expansions in the 5’ untranslated region of ABCD3 as a cause of oculopharyngodistal myopathy (OPDM) in individuals of European ancestry and identify increased expression of expansion-containing ABCD3 transcripts as a possible disease mechanism underlying muscle degeneration.

Andrea Cortese
Sarah J. Beecroft
Gianina Ravenscroft
ResearchOpen Access27 Jul 2024
Nature Communications

Volume: 15, P: 1-15
Publisher Correction: Butler enables rapid cloud-based analysis of thousands of human genomes

Sergei Yakneen
Sebastian M. Waszak
Jan O. Korbel
Amendments and CorrectionsOpen Access12 Feb 2020
Nature Biotechnology

Volume: 41, P: 578
Structure of bilirubin

RAYMOND BONNETT
JOHN E. DAVIES
MICHAEL B. HURSTHOUSE
Research01 Jul 1976
Nature

Volume: 262, P: 326-328
Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification

de Vries, Conomos, Singh and Nicholson et al. identify two additional loci associated with coronary artery calcification (ARSE and MMP16) via a genome-wide association study in 22,400 participants from multiple ancestral groups and prove that ARSE is a mediator of vascular smooth muscle cell calcification and phenotype switching.

Paul S. de Vries
Matthew P. Conomos
Rajeev Malhotra
Research04 Dec 2023
Nature Cardiovascular Research

Volume: 2, P: 1159-1172
Improving outcomes in kidney transplantation through advances in donor organ perfusion

A global shortage of suitable donor kidneys is the primary challenge in kidney transplantation. In this Review, the authors describe different methods of donor kidney preservation, discussing the strengths and limitations of each method and noting how advances in donor organ perfusion could improve organ utilization and patient outcomes.

James Hunter
Sarah Hosgood
Francois Pattou
Reviews09 Sept 2025
Nature Reviews Nephrology

P: 1-15
Genetic studies of body mass index yield new insights for obesity biology

A genome-wide association study and Metabochip meta-analysis of body mass index (BMI) detects 97 BMI-associated loci, of which 56 were novel, and many loci have effects on other metabolic phenotypes; pathway analyses implicate the central nervous system in obesity susceptibility and new pathways such as those related to synaptic function, energy metabolism, lipid biology and adipogenesis.

Adam E. Locke
Bratati Kahali
Elizabeth K. Speliotes
Research11 Feb 2015
Nature

Volume: 518, P: 197-206
Unique cytoplasmic phosphoproteins are associated with cell growth arrest

ROLF F. KLETZIEN
MICHAEL R. MILLER
ARTHUR B. PARDEE
Research03 Nov 1977
Nature

Volume: 270, P: 57-59
Evidence from earliest known erinaceomorph basicranium that insectivorans and primates are not closely related

Michael J. Novacek
Malcolm C. McKenna
Richard L. Cifelli
Research15 Dec 1983
Nature

Volume: 306, P: 683-684
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia

In heart muscle cells, a region of the sarcolemmal membrane periodically invaginates to form T tubules, a specialized membrane domain that contains important ion channels regulating cell contraction. Robin Shaw and his colleagues describe how a cardiac-specific splice variant of the isoform of the protein BIN1 helps make folds in T tubules, which affects the ability of ions in the extracellular space to freely diffuse and protects the heart from arrhythmia.

TingTing Hong
Huanghe Yang
Robin M Shaw
Research18 May 2014
Nature Medicine

Volume: 20, P: 624-632
Activation of a carbon–carbon bond in solution by transition-metal insertion

Michael Gozin
Alexander Weisman
David Milstein
Research19 Aug 1993
Nature

Volume: 364, P: 699-701
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Local cytoplasmic calcium gradients in living mitotic cells

Charles H. Keith
Rajiv Ratan
Michael L. Shelanski
Research29 Aug 1985
Nature

Volume: 316, P: 848-850
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Group 2 innate lymphoid cells (ILC2s) are generally considered to have pro-tumor functions. However, Belz and colleagues demonstrate that ILC2s have anti-melanoma effects due to their high production of the inflammatory cytokine granulocyte-macrophage colony-stimulating factor in the tumor microenvironment.

Nicolas Jacquelot
Cyril Seillet
Gabrielle T. Belz
Research07 Jun 2021
Nature Immunology

Volume: 22, P: 851-864
New genetic loci link adipose and insulin biology to body fat distribution

Genome-wide association meta-analyses of waist-to-hip ratio adjusted for body mass index in more than 224,000 individuals identify 49 loci, 33 of which are new and many showing significant sexual dimorphism with a stronger effect in women; pathway analyses implicate adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution.

Dmitry Shungin
Thomas W. Winkler
Karen L Mohlke
Research11 Feb 2015
Nature

Volume: 518, P: 187-196
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

A cross-ancestry genome-wide association meta-analysis of amyotrophic lateral sclerosis (ALS) including 29,612 patients with ALS and 122,656 controls identifies 15 risk loci with distinct genetic architectures and neuron-specific biology.

Wouter van Rheenen
Rick A. A. van der Spek
Jan H. Veldink
ResearchOpen Access06 Dec 2021
Nature Genetics

Volume: 53, P: 1636-1648
Direct observation of shape selectivity in zeolite ZSM-5 by magic-angle-spinning NMR

Michael W. Anderson
Jacek Klinowski
Research18 May 1989
Nature

Volume: 339, P: 200-203
Homing receptor-bearing thymocytes, an immunocompetent cortical subpopulation

Pamela J. Fink
W. Michael Gallatin
Irving L. Weissman
Research17 Jan 1985
Nature

Volume: 313, P: 233-235
Benefits for children with suspected cancer from routine whole-genome sequencing

In a cohort of 281 children with diagnosed or suspected cancer presenting to the NHS, implementing routine whole-genome sequencing provided clinical benefit in 29% of cases and led to change in management in 7% of patients.

Angus Hodder
Sarah M. Leiter
Sam Behjati
ResearchOpen Access02 Jul 2024
Nature Medicine

Volume: 30, P: 1905-1912
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Author Correction: The repertoire of mutational signatures in human cancer

Ludmil B. Alexandrov
Jaegil Kim
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E41
Effect of Atrial Natriuretic Peptide on Vascular Permeation in the Ovine Fetus

Michael Silberbach
Debra F Anderson
Lowell E Davis
Research01 May 1994
Pediatric Research

Volume: 35, P: 555-559
Dr. A. L. Hagedoorn

MICHAEL PEASE
Comments & Opinion09 Jan 1954
Nature

Volume: 173, P: 60-61
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer

Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating T cell fraction provides sex-dependent and prognostic insights in patients.

Robert Bentham
Thomas P. Jones
Nicholas McGranahan
ResearchOpen Access18 Feb 2025
Nature Genetics

Volume: 57, P: 694-705
The ecology of ecology

“Ecology has become a social movement as well as a branch of biology”. Philip Lowe of University College, London, and Michael Worboys of Sheffield City Polytechnic give their view on the role of science in the environmental movement

Philip Lowe
Michael Worboys
News05 Aug 1976
Nature

Volume: 262, P: 432-433
Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes

An integrated analysis of de novo and inherited coding variants in 42,607 individuals with autism spectrum disorder identifies 60 risk genes of which five have not previously been associated with neurodevelopmental disorders.

Xueya Zhou
Pamela Feliciano
Wendy K. Chung
ResearchOpen Access18 Aug 2022
Nature Genetics

Volume: 54, P: 1305-1319
Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Matthew H. Bailey
William U. Meyerson
Christian von Mering
Amendments and CorrectionsOpen Access30 Nov 2020
Nature Communications

Volume: 11, P: 1
Breast tumours maintain a reservoir of subclonal diversity during expansion

Single-cell analysis of genomes from primary human breast tumours and cell lines shows that chromosomal aberrations continue to evolve during primary tumour expansion, resulting in a milieu of subclones within the tumour.

Darlan C. Minussi
Michael D. Nicholson
Nicholas E. Navin
Research24 Mar 2021
Nature

Volume: 592, P: 302-308
Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Esther Rheinbay
Morten Muhlig Nielsen
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E40
The impact of the BDNF Val66Met genotype on intrusive memories following trauma exposure and in PTSD is moderated by sex and timing of trauma exposure

Emma Louise Nicholson
Michael Garry
Kim L. Felmingham
ResearchOpen Access22 Aug 2025
Scientific Reports

Volume: 15, P: 1-15
Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

Yulia Rubanova
Ruian Shi
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Combined burden and functional impact tests for cancer driver discovery using DriverPower

Shimin Shuai
Federico Abascal
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Kadir C. Akdemir
Victoria T. Le
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1079
Author Correction: Divergent mutational processes distinguish hypoxic and normoxic tumours

Vinayak Bhandari
Constance H. Li
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes

Matthew A. Reyna
David Haan
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Pan-cancer analysis of whole genomes

Lauri A. Aaltonen
Federico Abascal
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E39

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