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This study employs a functional genomic approach to identify a synthetic lethal interaction between CDS1 and CDS2 in uveal melanoma and other cancers, which may represent a potential therapeutic target.

The researchers demonstrate direct measurement and complete characterization of structured electronic wave packets created within a prototypical Fano resonance. The method may be broadly applicable to the study of ultrafast processes, especially electronic ones, in complex systems, as well as coherent control of such systems on their fundamental timescales.

Long-acting injectable drugs for viral suppression of HIV are not yet available in African settings. Here, the authors present a mathematical modelling and cost effectiveness study of a long-acting drug combination in adults living with HIV in East, Central, Southern and West Africa.

Antibody pairs are made to act selectively on cells co-expressing two targets by engineering their Fc domains.

Random two-dimensional arrays of carbon nanotubes, which are self-assembled via ion-exchange chemistry, can be used to create cryptographic keys by determining the connection yield and switching type of the nanotube devices.

Bhattacharjee and Schaeffer et al. map exclusive breastfeeding (EBF) in 94 low- and middle-income countries (LMICs), finding increased EBF practice and reduced subnational variation across the majority of LMICs from 2000 to 2018. However, only six LMICs will meet WHO’s target of ≥70% EBF by 2030 nationally, and only three will achieve this in all districts.

A connectome of the right optic lobe from a male fruitfly is presented together with an extensive collection of genetic drivers matched to a comprehensive neuron-type catalogue.

Nuclear spins in diamond are promising for applications in quantum technologies due to their long coherence times. Here, the authors demonstrate a scalable electrical readout of individual intrinsic ¹⁴N nuclear spins in diamond, mediated by hyperfine coupling to electron spin of the NV center, as a step towards room-temperature nanoscale diamond quantum devices.

Regulation of thymocyte development by RNA-binding proteins is not fully characterized. Here the authors show the RBP ARPP21 interacting with the Rag1 3’-UTR to promote Rag1 expression, TCR rearrangement and an increased diversity of the TCR repertoire and that ARPP21 is down regulated by TCR stimulation.

Ultracold atoms in arrays represent a useful platform to study quantum processes. Here the authors use Floquet frequency modulation to entangle neutral atoms beyond the usual Rydberg blockade range, protect entangled-state coherence, and realize Rydberg anti-blockade states for two atoms at close range.

Germinal centers are typically divided into dark and light zones. Clark and colleagues identify ‘gray zone’ cyclin B1⁺ B cell clusters as sites of ongoing cell proliferation, and these cells are distinct from dark zone B cells that undergo AID-dependent somatic hypermutation. This separation of function safeguards B cells undergoing DNA replication against potential mutagenic events that could result in neoplastic transformation.

Neurotransmitter:sodium symporters (NSS) serve as targets for drugs including antidepressants and psychostimulants. Here authors report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na⁺/substrate-bound, inward-facing occluded conformation which is a key intermediate in the LeuT transport cycle.

While different types of low-power transistors have been investigated, low voltage rectifiers able to overcome the thermionic limit have not been proposed yet. Here, the authors report the realization of Dirac-source diodes based on graphene/MoS2/graphite heterostructures, showing ideality factors <1 and rectifying ratios exceeding 10⁸ at room temperature.

Recent estimates of sugar-sweetened beverages (SSBs) intake are generally unavailable. Here the authors show a global SSBs intake of 2.7 servings/week in 2018 in adults (range: 0.7 South Asia, 7.8 Latin America/Caribbean); intakes were higher among males, younger, more educated, and urban adults.

Metastatic cells can mimic many of the phenotypic behaviors of embryonic cells. Here, the authors generate a melanoblast-specific transcriptome using a genetically engineered mouse model and identify KDELR3 as a pro-metastasis gene in melanoma.

Jacobsen and colleagues elucidate the nonhierarchical relationship between two types of stem cells: Vwf⁻ hematopoietic stem cells that stably replenish all blood cell lineages without a platelet bias, and Vwf⁺ stem cells that replenish almost exclusively platelets, and demonstrate that the two types utilize cellularly and molecularly distinct progenitor trajectories for replenishment of platelets.

A fluorescent reporter, named traffic light, reads out whether repair of a DNA break occurs by nonhomologous end-joining or by homologous recombination. It should enable the identification of factors that affect repair pathway choice and thus improved approaches for genome engineering.

Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological data from two large human cohorts.

DNA methylation is a critical component for repression of fetal haemoglobin in adult blood cells. Removing DNA methylation from the fetal haemoglobin promoter effectively upregulates the gene, opening avenues for the treatment of blood disorders.

Topological quantum error correction is a promising approach towards fault-tolerant quantum computing, but suffers from large time overhead. Here, the authors generalise the stabiliser toric code to a single-shot 3D subsystem toric code, featuring good performance and resilience to measurement errors.

Paiardini and colleagues describe a subset of lymph node HIV- and SIV-specific TOX^hiTCF1⁺CD39⁺CD8⁺ T cells that coexhibit stem- and effector-like phenotypic and transcriptional profiles and associate with reduced viral burden.

Sodium glucose transporters are critical for maintaining glucose homeostasis. Here, authors provide a detailed framework for how SGLTs utilize cellular membrane potentials to stabilize their substrate accepting conformation leading to accelerated transport.

A meta-analysis using the Burden of Proof method found increased but modest relative risk of cardiometabolic disease and/or colorectal cancer associated with the consumption of processed meat, sugar-sweetened beverages and trans fatty acids.

A study establishes a scalable approach to engineer and characterize a many-body-localized discrete time crystal phase on a superconducting quantum processor.

The choroid plexus (ChP) provides molecular cues for brain development. However, the underlying mechanisms are unclear. This study identifies an apocrine secretion mechanism in the ChP that modulates the CSF protein composition and instructs cortical development.

A flexible AI framework integrates multimodal neurology work-up data to estimate amyloid and tau burden, supporting scalable biomarker stratification for Alzheimer’s disease research and trial screening.

Hypothalamus participates in systemic metabolic processes, while high calorie intake increases immune activation in the central nervous system. Here the authors show that reduced regulatory T cells in the hypothalamus contribute to elevated immune activation in a high calorie environment, thereby prompting a potential therapy target for metabolic diseases.

Optical computing often employs tailor-made hardware to implement specific algorithms, trading generality for improved performance in key aspects like speed and power efficiency. We propose an experimentally viable photonic approach to solve arbitrary probabilistic computing problems, used e.g. for solving difficult combinatorial optimization problems.

A pan-cancer epigenetic and transcriptomic atlas identifies epigenetic drivers associated with cancer transitions.

Through cryo-EM analysis, here authors reveal conformational rearrangements that are critical for the gating mechanism of the human alpha3 Na+/K+−ATPase

Tuberculosis is a major cause of mortality, and the rise of drug-resistant strains of Mycobacterium tuberculosis requires the urgent development of safe and effective treatments. In this work, the authors develop a compound against lysyl-tRNA synthetase, demonstrating on-target mechanism of action and efficacy in vivo.

Disorder has been a prime challenge to study the topological properties in a hybrid system. Here, Zhanget al. report ballistic superconductivity in InSb nanowires interfacing with a NbTiN superconductor, paving the way for disorder-free Majorana devices.

Single-photon sources are important for quantum optical technologies, although achieving efficient light extraction from them with waveguides is limited in top-down approaches. Reimeret al. show a high extraction efficiency using a bottom-up method to grow quantum dots on the axis of nanowire waveguides.

Nuclear spins in gallium arsenide produce noise at discrete frequencies, which can be notch-filtered efficiently to extend coherence times of electron spin qubits to nearly 1 ms.

The molecular determinants of gating and regulation of the calcium channel Orai1 by the ER Ca²⁺ sensor STIM1 during store-operated calcium entry are now defined.

Growth of high-quality III–V semiconductors for electronics and optoelectronics usually requires an atomic-lattice matched substrate. Here, the authors use templated liquid-phase crystal growth to create single-crystalline III–V material up to ten micrometres across on an amorphous substrate.

Some enhancers can limit their activities to specific spatial–temporal domains by enhancer suboptimization. Ou et al. find that classical dendritic cell (cDC) development depends on Irf8 suboptimization, which prevents unwanted IRF8 autoactivation in developing cDC2s while maximizing IRF8 expression in developed cDC1s.

How different cell types in primary motor cortex contribute to movement during learning and/or execution is not fully understood. Here authors show that corticothalamic neurons of the primary motor cortex are silent during movement and that this activity signature is critical for proficient movement generation.

A distribution in fin widths, due to variability in the fabrication process, can be used to study a latching condition in gallium nitride transistors in which drain current sharply transits from an off-state value to a high on-state value with a slope of less than 60 mV per decade.

Here the authors demonstrate that the assembly of mitochondrial respiratory supercomplex (III₂–IV) from Toxoplasma gondii is critical for parasite fitness. They reveal the basis for cytochrome b inhibition by atovaquone and improved ELQ inhibitors.