Nature Search

Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human β-cardiac myosin allosterically

Hypertrophic cardiomyopathy-causing mutations in cardiac myosin disrupt its auto-inhibited OFF state, leading to hypercontractility. Here, the authors show that disease-linked mutations remote from intramolecular OFF state interfaces can allosterically impair myosin autoinhibition

Neha Nandwani
Debanjan Bhowmik
Kathleen M. Ruppel
ResearchOpen Access01 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Bioassay of a Drosophila pheromone influencing sexual selection

JACK E. LEONARD
LEE EHRMAN
MICHAEL SCHORSCH
Research19 Jul 1974
Nature

Volume: 250, P: 261-262
Monitoring in real time and far-red imaging of H₂O₂ dynamics with subcellular resolution

This paper highlights the far-red chemigenetic H₂O₂ reporter oROS-HT₆₃₅, which enables detailed insights into intricate intracellular and intercellular H₂O₂ dynamics, along with their environmental interactants, through spatially resolved, multiplexed real-time H₂O₂ imaging.

Justin Daho Lee
Amanda Nguyen
Andre Berndt
Research28 Apr 2025
Nature Chemical Biology

P: 1-12
The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling

MALT1 mediates NFκB activation. Here the authors perform proteomic analysis of human immunodeficient mutant MALT1 B cells revealing that MALT1 cleaves the HOIL1 subunit of the linear ubiquitin chain assembly complex to dampen late NFκB activation and to invoke negative feedback of NFκB activation.

Theo Klein
Shan-Yu Fung
Christopher M. Overall
ResearchOpen Access03 Nov 2015
Nature Communications

Volume: 6, P: 1-17
Machine learning-guided engineering of genetically encoded fluorescent calcium indicators

Andre Berndt and colleagues introduce a machine learning approach to enhance the biophysical characteristics of genetically encoded fluorescent indicators, deriving and testing in vitro new GCaMP mutations that surpass the performance of existing fast GCaMP indicators.

Sarah J. Wait
Marc Expòsit
Andre Berndt
Research21 Mar 2024
Nature Computational Science

Volume: 4, P: 224-236
Correction: Corrigendum: Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma

Terri A Addona
Susan E Abbatiello
Steven A Carr
Amendments and Corrections01 Sept 2009
Nature Biotechnology

Volume: 27, P: 864
A comprehensive quantification of global nitrous oxide sources and sinks

Bottom-up and top-down approaches are used to quantify global nitrous oxide sources and sinks resulting from both natural and anthropogenic sources, revealing a 30% increase in global human-induced emissions between 1980 and 2016.

Hanqin Tian
Rongting Xu
Yuanzhi Yao
Research07 Oct 2020
Nature

Volume: 586, P: 248-256
The ocular presentation of neurofibromatosis 2

Nicola K Ragge
Michael E Baser
Rena E Falk
Research01 Jan 1997
Eye

Volume: 11, P: 12-18
Split intein-mediated protein trans-splicing to express large dystrophins

A method is developed for expressing large dystrophins to enhance muscle function in mouse models of muscular dystrophy, with potential clinical benefits for numerous disorders caused by mutations in large genes that exceed the adeno-associated virus capacity.

Hichem Tasfaout
Christine L. Halbert
Jeffrey S. Chamberlain
Research17 Jul 2024
Nature

Volume: 632, P: 192-200
Aficamten reduces cardiac contractility by modifying the actomyosin interaction

Aficamten, a small-molecule myosin inhibitor, binds to the catalytic domain of cardiac myosin and reduces contraction by stabilizing the initial weak interaction between myosin and actin.

Farid Moussavi-Harami
Michael Regnier
News & Views23 Jul 2024
Nature Cardiovascular Research

Volume: 3, P: 893-894
Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration

Cell therapy in a rat model of heart attack is enhanced by stem-cell-derived epicardium.

Johannes Bargehr
Lay Ping Ong
Sanjay Sinha
Research02 Aug 2019
Nature Biotechnology

Volume: 37, P: 895-906
The solution structure of the first KH domain of FMR1, the protein responsible for the fragile X syndrome

The structure and dynamics of the first KH domain of FMR1 — the protein responsible for fragile X syndrome — reveal that an exposed loop is highly flexible despite containing a GxxG motif that is well conserved throughout the KH family. We suggest that this region provides a putative binding surface for RNA recognition.

Giovanna Musco
Abdelhakim Kharrat
Annalisa Pastore
Correspondence01 Sept 1997
Nature Structural Biology

Volume: 4, P: 712-716
An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient

An allosteric inhibitor of the proteolytic activity of the CBM signalosome complex scaffolding protein MALT1 acts as a pharmacological chaperone to stabilize a mutant MALT1 carried by an immunodeficient patient.

Jean Quancard
Theo Klein
Christopher M. Overall
Research28 Jan 2019
Nature Chemical Biology

Volume: 15, P: 304-313
Activation of the NF-κB pathway by Caspase 8 and its homologs

Preet M Chaudhary
Michael T Eby
Leroy Hood
Research14 Sept 2000
Oncogene

Volume: 19, P: 4451-4460
The born-digital in future digital scholarly editing and publishing

James O’Sullivan
Michael Pidd
ResearchOpen Access09 Dec 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-8
Alarm communication predates eusociality in termites

The vibroacoustic and chemical alarm communication in the wood roach Cryptocercus and in 20 termite species are studied to reveal that the Neoisoptera species have developed the most sophisticated communication system, which could contribute towards their ecological success.

David Sillam-Dussès
Vojtěch Jandák
Jan Šobotník
ResearchOpen Access21 Jan 2023
Communications Biology

Volume: 6, P: 1-12
Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice

Frank Gillardon
Ingrid Moll
Theologos M Michaelidis
Research11 Jan 1999
Cell Death & Differentiation

Volume: 6, P: 55-60
How NF-κB is activated: the role of the IκB kinase (IKK) complex

Michael Karin
Research22 Nov 1999
Oncogene

Volume: 18, P: 6867-6874
Modulation of the NF-κB pathway by virally encoded Death Effector Domains-containing proteins

Preet M Chaudhary
Alan Jasmin
Leroy Hood
Research13 Oct 1999
Oncogene

Volume: 18, P: 5738-5746
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma

Although multiple reaction monitoring (MRM) mass spectrometry holds considerable promise for quantifying candidate protein biomarkers in blood, transferability of MRM assays between laboratories has never been shown. Addona et al. assess the reproducibility, dynamic range and limits of detection and quantification of MRM across multiple sites.

Terri A Addona
Susan E Abbatiello
Steven A Carr
Research28 Jun 2009
Nature Biotechnology

Volume: 27, P: 633-641
Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant

Bassel Akache
Tyler M. Renner
Michael J. McCluskie
ResearchOpen Access08 Nov 2021
Scientific Reports

Volume: 11, P: 1-17
A postnatal role for embryonic myosin revealed by MYH3 mutations that alter TGFβ signaling and cause autosomal dominant spondylocarpotarsal synostosis

Jennifer Zieba
Wenjuan Zhang
Deborah Krakow
ResearchOpen Access16 Feb 2017
Scientific Reports

Volume: 7, P: 1-9
Neurodevelopmental outcomes after red cell transfusion exposure in male versus female extremely preterm infants

Kendell German
Thomas R. Wood
Magaly Diaz-Barbosa
Research02 Jun 2025
Pediatric Research

P: 1-9
Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning

Max M. Owens
Matthew D. Albaugh
Gunter Schumann
ResearchOpen Access06 May 2022
Translational Psychiatry

Volume: 12, P: 1-9
Transfusions and neurodevelopmental outcomes in extremely low gestation neonates enrolled in the PENUT Trial: a randomized clinical trial

Phuong T. Vu
Robin K. Ohls
John A. Widness
Research11 Jan 2021
Pediatric Research

Volume: 90, P: 109-116
Immunogenicity of SARS-CoV-2 spike antigens derived from Beta & Delta variants of concern

Bassel Akache
Tyler M. Renner
Michael J. McCluskie
ResearchOpen Access12 Oct 2022
npj Vaccines

Volume: 7, P: 1-7
Targeting the affective brain—a randomized controlled trial of real-time fMRI neurofeedback in patients with depression

David M. A. Mehler
Moses O. Sokunbi
David E. J. Linden
ResearchOpen Access23 Jun 2018
Neuropsychopharmacology

Volume: 43, P: 2578-2585
Open science resources for the discovery and analysis of Tara Oceans data

Stéphane Pesant
Fabrice Not
Patrick Wincker
ResearchOpen Access26 May 2015
Scientific Data

Volume: 2, P: 1-16

Search

Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human β-cardiac myosin allosterically

Bioassay of a Drosophila pheromone influencing sexual selection

Monitoring in real time and far-red imaging of H₂O₂ dynamics with subcellular resolution

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling

Machine learning-guided engineering of genetically encoded fluorescent calcium indicators

Correction: Corrigendum: Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma

A comprehensive quantification of global nitrous oxide sources and sinks

The ocular presentation of neurofibromatosis 2

Split intein-mediated protein trans-splicing to express large dystrophins

Aficamten reduces cardiac contractility by modifying the actomyosin interaction

Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration

The solution structure of the first KH domain of FMR1, the protein responsible for the fragile X syndrome

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient

Activation of the NF-κB pathway by Caspase 8 and its homologs

The born-digital in future digital scholarly editing and publishing

Alarm communication predates eusociality in termites

Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice

How NF-κB is activated: the role of the IκB kinase (IKK) complex

Modulation of the NF-κB pathway by virally encoded Death Effector Domains-containing proteins

Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma

Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant

A postnatal role for embryonic myosin revealed by MYH3 mutations that alter TGFβ signaling and cause autosomal dominant spondylocarpotarsal synostosis

Neurodevelopmental outcomes after red cell transfusion exposure in male versus female extremely preterm infants

Bayesian causal network modeling suggests adolescent cannabis use accelerates prefrontal cortical thinning

Transfusions and neurodevelopmental outcomes in extremely low gestation neonates enrolled in the PENUT Trial: a randomized clinical trial

Immunogenicity of SARS-CoV-2 spike antigens derived from Beta & Delta variants of concern

Targeting the affective brain—a randomized controlled trial of real-time fMRI neurofeedback in patients with depression

Open science resources for the discovery and analysis of Tara Oceans data

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