Nature Search

Genome-wide in vivo CRISPR screens identify GATOR1 complex as a tumor suppressor in Myc-driven lymphoma

Identifying genes involved in MYC-driven lymphoma reveals therapeutic vulnerabilities. Here, the authors show by using CRISPR knockout screens in primary cells in vivo that the GATOR1 complex suppresses MYC-driven lymphomagenesis, and that GATOR1-deficient lymphomas are sensitive to mTOR inhibitors.

Margaret A. Potts
Shinsuke Mizutani
Marco J. Herold
ResearchOpen Access21 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Overexpression of the bcl-2 oncogene in the mouse pre-B cell line SPGM-1 protects from apoptosis, but does not affect blocked B-lineage differentiation and lineage switch towards macrophage like cells

Detlef Neumann
Andreas Strasser
Michael Uwe Martin
Research01 Oct 1997
Cell Death & Differentiation

Volume: 4, P: 580-589
Challenges and opportunities in neonatal monitoring: insights on forehead photoplethysmography sensors

Lena Strasser
Tereza Schedler
Michael Wagner
Comments & OpinionOpen Access22 Sept 2025
Pediatric Research

P: 1-2
Crm-A, bcl-2 and NDGA inhibit CD95L-induced apoptosis of malignant glioma cells at the level of caspase 8 processing

Bettina Wagenknecht
Jörg B Schulz
Michael Weller
Research22 Oct 1998
Cell Death & Differentiation

Volume: 5, P: 894-900
Wild and domesticated animal abundance is associated with greater late-Holocene alpine plant diversity

The role of wild and domesticated animals on alpine ecosystems is unclear. Here, the authors use sedaDNA from 14 European alpine lakes to demonstrate a positive association between wild and domesticated animal and plant diversity through the past 14 thousand years.

Sandra Garcés-Pastor
Peter D. Heintzman
Inger Greve Alsos
ResearchOpen Access25 Apr 2025
Nature Communications

Volume: 16, P: 1-11
Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

How the brain’s antioxidant defenses adapt to changing demand is not well understood. Here the authors demonstrate that synaptic activity is coupled to transcriptional control of the glutathione antioxidant system via NMDA receptors, enabling neurons to tune their antioxidant defenses.

Paul S. Baxter
Karen F.S. Bell
Giles E. Hardingham
ResearchOpen Access09 Apr 2015
Nature Communications

Volume: 6, P: 1-13
Earthquake-enhanced dissolved carbon cycles in ultra-deep ocean sediments

Earthquakes enhance dissolved carbon production and fuel the microbial activities in hadal trench subsurface sediments, and ultimately strengthen carbon accumulation and transformation in the subduction zones.

Mengfan Chu
Rui Bao
Sarah Zellers
ResearchOpen Access11 Sept 2023
Nature Communications

Volume: 14, P: 1-9
Quantification of Cell Movement Reveals Distinct Edge Motility Types During Cell Spreading

Benjamin Dubin-Thaler Ph.D.
Jake Hofman Ph.D.
Michael Sheetz
ResearchOpen Access09 Jul 2007
Nature Precedings

P: 1
Genes of the serotonergic and dopaminergic pathways and their interaction affect the expression of Behavioural and Psychological Symptoms in Dementia (BPSD).

Petroula Proitsi
Michelle Lupton
John Powell
ResearchOpen Access26 Oct 2009
Nature Precedings

P: 1
Glycine receptor β–subunit gene mutation in spastic mouse associated with LINE–1 element insertion

Stephen F. Kingsmore
Bruno Giros
Michael F. Seldin
Research01 Jun 1994
Nature Genetics

Volume: 7, P: 136-142
Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

Michael O. Hengartner
Ronald Ellis
Robert Horvitz
Research09 Apr 1992
Nature

Volume: 356, P: 494-499
Bioturbation in the hadal zone

To better understand bioturbation in the hadal zone, the authors here examine sediment cores collected from depths of more than 7.5 km. They characterise biogenic sedimentary structures, colonization patterns, and their relation to gravity flow events.

Jussi Hovikoski
Joonas J. Virtasalo
Ken Ikehara
ResearchOpen Access18 Feb 2025
Nature Communications

Volume: 16, P: 1-13
Electrochemical synthesis of propylene from carbon dioxide on copper nanocrystals

The electrochemical reduction of carbon dioxide to propylene requires multiple C–C coupling steps and the transfer of 18 electrons, posing kinetic and thermodynamic barriers. Now the electrosynthesis of propylene from carbon dioxide using copper nanocrystals has been demonstrated, with analysis revealing that the key step for its formation is probably the coupling between carbon dioxide or carboxyl with intermediates involved in the ethylene pathway.

Jing Gao
Alimohammad Bahmanpour
Michael Grätzel
ResearchOpen Access06 Apr 2023
Nature Chemistry

Volume: 15, P: 705-713
Heterologous Gene Expression in Hansenula Polymorpha: Efficient Secretion of Glucoamylase

Gerd Gellissen
Zbigniew A. Janowicz
Alexander W.M. Strasser
Research01 Mar 1991
Bio/Technology

Volume: 9, P: 291-295
Removal of dissolved organic carbon in the West Pacific hadal zones

Deep-sea dissolved organic carbon is significantly removed within hadal trenches, positioning these regions as critical sinks in the global DOC pool and highlighting a potential coupling between the marine carbon cycle and tectonic activity.

Mengfan Chu
Rui Bao
Ellen Druffel
ResearchOpen Access16 Jan 2025
Nature Communications

Volume: 16, P: 1-10
p53-induced apoptosis in the human T-ALL cell line CCRF-CEM

Stephan Geley
Bernd L Hartmann
Reinhard Kofler
Research13 Nov 1997
Oncogene

Volume: 15, P: 2429-2437
Re-appraising assays on permeabilized blood cancer cells testing venetoclax or other BH3 mimetic agents selectively targeting pro-survival BCL2 proteins

Jia-Nan Gong
Tirta M. Djajawi
David C. S. Huang
ResearchOpen Access09 Apr 2025
Cell Death & Differentiation

Volume: 32, P: 1382-1396
Protection against mycoplasma infection using expression-library immunization

Michael A. Barry
Wayne C. Lai
Stephen Albert Johnston
Research19 Oct 1995
Nature

Volume: 377, P: 632-635
Platelet-dependent stimulation of prostacyclin synthesis by platelet-derived growth factor

Shaun R. Coughlin
Michael A. Moskowitz
Lawrence Levine
Research11 Dec 1980
Nature

Volume: 288, P: 600-602
Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

Michael D. Jacobson
Julia F. Burne
Martin C. Raff
Research28 Jan 1993
Nature

Volume: 361, P: 365-369
Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

Michael T. Hemann
Anka Bric
Scott W. Lowe
Research11 Aug 2005
Nature

Volume: 436, P: 807-811
Overexpression of Bax gene sensitizes K562 erythroleukemia cells to apoptosis induced by selective chemotherapeutic agents

Tohru Kobayashi
Sanbao Ruan
Wei Zhang
Research01 Apr 1998
Oncogene

Volume: 16, P: 1587-1591
Tectonically-triggered sediment and carbon export to the Hadal zone

Within sediments in deep ocean trenches an earthquake record may be observed. Here, the authors present ¹⁴C data on bulk organic carbon (OC) and thermal decomposition from a sediment core in the Japan Trench and match OC values with known earthquake events.

Rui Bao
Michael Strasser
Timothy I. Eglinton
ResearchOpen Access09 Jan 2018
Nature Communications

Volume: 9, P: 1-8
Reduced Na⁺, K⁺-ATPase Activity in Patients with Pseudohypoaldosteronism

Tzvy Bistritzer
Sandra Evans
Mordechai Aladjem
Research01 Mar 1994
Pediatric Research

Volume: 35, P: 372-375
Dual quantum spin Hall insulator by density-tuned correlations in TaIrTe₄

A study reports a dual quantum spin Hall insulator in monolayer TaIrTe₄, arising from the interplay of its single-particle topology and density-tuned electron correlations.

Jian Tang
Thomas Siyuan Ding
Qiong Ma
Research20 Mar 2024
Nature

Volume: 628, P: 515-521
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

Peter Listen
Natalie Roy
Robert G. Korneluk
Research25 Jan 1996
Nature

Volume: 379, P: 349-353
Bcl-x_L forms an ion channel in synthetic lipid membranes

Andy J. Minn
Patricio Vélez
Craig B. Thompson
Research23 Jan 1997
Nature

Volume: 385, P: 353-357
A CO₂ electrolyzer tandem cell system for CO₂-CO co-feed valorization in a Ni-N-C/Cu-catalyzed reaction cascade

Tandem concepts for electroreduction of CO₂ offer a valuable toolkit to tackle sluggish reaction kinetics and raise the production of e-chemicals. Here, the authors report a cascade system with two coupled electrolyzers using Ni-N-C and Cu-based catalysts for enhanced CO₂ to multi-carbon conversion

Tim Möller
Michael Filippi
Peter Strasser
ResearchOpen Access14 Sept 2023
Nature Communications

Volume: 14, P: 1-10
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

Margot Thome
Pascal Schneider
Jürg Tschopp
Research03 Apr 1997
Nature

Volume: 386, P: 517-521
Origin and evolution of a splay fault in the Nankai accretionary wedge

The sedimentary wedge in the Nankai Trough off the coast of Japan is cut by a landward-dipping thrust fault, which is an important plate boundary structure in this region. Geological and seismic reflection data indicate that the fault initiated ∼1.95 million years ago and underwent uplift and reactivation ∼1.55 million years ago.

Michael Strasser
Gregory F. Moore
Xixi Zhao
Research16 Aug 2009
Nature Geoscience

Volume: 2, P: 648-652
Unraveling the synergistic effects of Cu-Ag tandem catalysts during electrochemical CO₂ reduction using nanofocused X-ray probes

Combining in situ nanoprobe techniques paves the way for gaining insights into structure-selectivity relations for electrocatalysts. Herein, the dynamic evolution of lattice strain in individual nanoparticles is directly visualized with nanoscale resolution in Cu-Ag tandem catalysts during the electrocatalytic conversion of CO2 into value-added chemicals.

Marvin L. Frisch
Longfei Wu
Peter Strasser
ResearchOpen Access29 Nov 2023
Nature Communications

Volume: 14, P: 1-9
Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols

Nena Mirkovic
David W Voehringer
Raymond E Meyn
Research18 Sept 1997
Oncogene

Volume: 15, P: 1461-1470
Subduction zone earthquake as potential trigger of submarine hydrocarbon seepage

Methane is abundant in marine sediments. Analysis of sediment cores and seismic images of marine sediments obtained off the coast of Pakistan show fracturing of gas hydrates and an increase in upward methane flux in the decades following a large earthquake in the Arabian Sea in 1945, suggesting that quakes can trigger hydrocarbon seepage.

David Fischer
José M. Mogollón
Sabine Kasten
Research28 Jul 2013
Nature Geoscience

Volume: 6, P: 647-651
c-Myc does not prevent glucocorticoid-induced apoptosis of human leukemic lymphoblasts

Markus Löffler
Michael J Ausserlechner
Reinhard Kofler
Research18 Aug 1999
Oncogene

Volume: 18, P: 4626-4631
Seismic control of large prehistoric rockslides in the Eastern Alps

The authors here present a multi-lake paleoseismological approach to evaluate the role of earthquakes in causing a spatio-temporal cluster of large, prehistoric rockslides between 3000 and 4200 years ago in the Eastern European Alps and for which the triggering mechanisms are still debated.

Patrick Oswald
Michael Strasser
Jasper Moernaut
ResearchOpen Access16 Feb 2021
Nature Communications

Volume: 12, P: 1-8
Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice

Frank Gillardon
Ingrid Moll
Theologos M Michaelidis
Research11 Jan 1999
Cell Death & Differentiation

Volume: 6, P: 55-60
TNFα-mediated cell death is independent of Cdc25A

George Krupitza
Michael Grusch
Markus Hengstschläger
Research03 Sept 1998
Cell Death & Differentiation

Volume: 5, P: 758-764
Wild-type function of the p53 tumor suppressor protein is not required for apoptosis of mouse hepatoma cells

Christina Unger
Albrecht Buchmann
Michael Schwarz
Research28 Jan 1998
Cell Death & Differentiation

Volume: 5, P: 87-95
Lattice-strain control of the activity in dealloyed core–shell fuel cell catalysts

The rational design of catalytic materials requires synthetic control over their reactive properties. Now, the activity of dealloyed Pt–Cu bimetallic nanoparticles, which catalyse the oxygen reduction reaction, can be tuned through control of the geometric strain at their surface.

Peter Strasser
Shirlaine Koh
Anders Nilsson
Research25 Apr 2010
Nature Chemistry

Volume: 2, P: 454-460
Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells

Mcl-1 is an important survival factor for several hematopoietic lineages including B and T lymphocytes, but its role in the Natural Killer (NK) cells has not been previously tested. Here, the authors report that deletion of Mcl-1 in the NK cell lineage leads to the loss of NK cells from all tissues.

Priyanka Sathe
Rebecca B. Delconte
Nicholas D. Huntington
Research14 Aug 2014
Nature Communications

Volume: 5, P: 1-10
Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways

Platelet production has been suggested to occur by apoptosis of megakaryocytes, but mitochondrially mediated apoptosis is known to be dispensable. Here, the authors show that death receptor-mediated apoptosis in mouse megakaryocytes is also not required for platelet biogenesis.

Emma C. Josefsson
Deborah L. Burnett
Benjamin T. Kile
Research17 Mar 2014
Nature Communications

Volume: 5, P: 1-14
Talin and kindlin use integrin tail allostery and direct binding to activate integrins

Here, the authors show how binding of talin and kindlin to the β-integrin cytoplasmic tail increases talin and decreases kindlin affinity toward it, providing insights into mechanisms of integrin activation.

Jonas Aretz
Masood Aziz
Reinhard Fässler
ResearchOpen Access12 Dec 2023
Nature Structural & Molecular Biology

Volume: 30, P: 1913-1924
Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

A substantial obstacle in basic research is the use of poorly validated tool compounds with purported useful biological functions. Here, the authors systematically profile widely used histone acetyltransferase inhibitors and find that the majority are nonselective interference compounds.

Jayme L. Dahlin
Kathryn M. Nelson
Michael A. Walters
ResearchOpen Access15 Nov 2017
Nature Communications

Volume: 8, P: 1-14
Transgenic N-myc mouse model for indolent B cell lymphoma: tumor characterization and analysis of genetic alterations in spontaneous and retrovirally accelerated tumors

Rachel D Sheppard
Sadhana A Samant
Michael D Cole
Research21 Oct 1998
Oncogene

Volume: 17, P: 2073-2085
Prospective identification of hematopoietic lineage choice by deep learning

A deep learning approach enables fast and robust prediction of hematopoietic stem cell lineage choice in time-lapse imaging three generations before conventional marker onset.

Felix Buggenthin
Florian Buettner
Carsten Marr
Research20 Feb 2017
Nature Methods

Volume: 14, P: 403-406
Atomic-resolution mapping of transcription factor-DNA interactions by femtosecond laser crosslinking and mass spectrometry

Cross-linking mass spectrometry (MS) is an important tool in structural biology, but its application to protein-DNA complexes has been hampered by low cross-linking efficiency. Here, the authors develop a femtosecond UV-laser induced cross-linking MS workflow to map protein-DNA interactions in vitro and in cells.

Alexander Reim
Roland Ackermann
Michael Wierer
ResearchOpen Access15 Jun 2020
Nature Communications

Volume: 11, P: 1-14
Lineage marker synchrony in hematopoietic genealogies refutes the PU.1/GATA1 toggle switch paradigm

The timing of cell fate choices is usually unknown, because we have to rely on indirect evidence of their molecular basis. Here, the authors introduce a method to infer decision times from marker onset in cell genealogies, and find evidence refuting the paradigmatic PU.1/GATA1 cell fate switch.

Michael K. Strasser
Philipp S. Hoppe
Carsten Marr
ResearchOpen Access12 Jul 2018
Nature Communications

Volume: 9, P: 1-10
Death ligand/receptor-independent caspase activation mediates drug-induced cytotoxic cell death in human malignant glioma cells

Tamara Glaser
Bettina Wagenknecht
Michael Weller
Research14 Sept 1999
Oncogene

Volume: 18, P: 5044-5053
Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice

Brian J Feldman
Tony R Reid
Michael L Cleary
Research27 Nov 1997
Oncogene

Volume: 15, P: 2735-2742
Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios

Live imaging and single-cell analyses are used to show that decision-making by differentiating haematopoietic stem cells between the megakaryocytic–erythroid and granulocytic–monocytic lineages is not initiated by stochastic switching between the lineage-specific transcription factors PU.1 and GATA1, which challenges the previous model of early myeloid lineage choice.

Philipp S. Hoppe
Michael Schwarzfischer
Timm Schroeder
Research13 Jul 2016
Nature

Volume: 535, P: 299-302

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