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IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition

The role of IgG glycosylation in the immune response has been studied, but less is known about IgM glycosylation. Here the authors characterize glycosylation of SARS-CoV-2 spike specific IgM and show that it correlates with COVID-19 severity and affects complement deposition.

Benjamin S. Haslund-Gourley
Kyra Woloszczuk
Mary Ann Comunale
ResearchOpen Access09 Jan 2024
Nature Communications

Volume: 15, P: 1-19
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients

Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

Harry Pickering
Joanna Schaenman
Charles R. Langelier
ResearchOpen Access10 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Machine learning models predict long COVID outcomes based on baseline clinical and immunologic factors

Jayavelu, Samaha et al., apply machine learning models on hospital admission data, including antibody titers and viral load, to identify patients at high risk for Long COVID. Low antibody levels, high viral loads, chronic diseases, and female sex are key predictors, supporting early, targeted interventions.

Naresh Doni Jayavelu
Hady Samaha
Matthew C. Altman
ResearchOpen Access03 Jan 2026
Communications Medicine

Volume: 6, P: 1-10
Author Correction: Machine learning models predict long COVID outcomes based on baseline clinical and immunologic factors

Naresh Doni Jayavelu
Hady Samaha
Matthew C. Altman
Amendments and CorrectionsOpen Access23 Feb 2026
Communications Medicine

Volume: 6, P: 1
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

Post-acute sequelae of SARS-CoV-2 (PASC) is still not well understood. Here the authors provide patient reported outcomes from 590 hospitalized COVID-19 patients and show association of PASC with higher respiratory SARS-CoV-2 load and circulating antibody titers, and in some an elevation in circulating fibroblast growth factor 21.

Al Ozonoff
Naresh Doni Jayavelu
Nadine Rouphael
ResearchOpen Access03 Jan 2024
Nature Communications

Volume: 15, P: 1-17
DNA vaccines: ready for prime time?

In the past 16 years, there has been much excitement in the area of DNA vaccine development for a range of medical conditions. The recent licensure of DNA vaccines for veterinary use bodes well for applications in humans, in which progress has been slower.

Michele A. Kutzler
David B. Weiner
Reviews01 Oct 2008
Nature Reviews Genetics

Volume: 9, P: 776-788
Author Correction: Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals

Jennifer Connors
David Joyner
Elias K. Haddad
Amendments and CorrectionsOpen Access22 Feb 2025
Communications Biology

Volume: 8, P: 1
Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals

The role of empty lipid nanoparticles in eliciting dendritic cell maturation and innate immune signaling is shown to be impaired in older adults, potentially contributing to lower immune responses to SARS-CoV-2 mRNA-based vaccines.

Jennifer Connors
David Joyner
Elias K. Haddad
ResearchOpen Access17 Feb 2023
Communications Biology

Volume: 6, P: 1-13

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