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Showing 1–50 of 68 results

Advanced filters: Author: Miguel F. Segura Clear advanced filters

Reduced brain structural similarity is associated with maturation, neurobiological features, and clinical status in schizophrenia

Individuals with schizophrenia show reduced structural similarity in temporal, cingulate, and insular lobes, especially those with worse cognition and symptoms, affecting late maturing association areas with low metabolism and high neurotransmission.

Natalia García-San-Martín
Richard AI Bethlehem
Rafael Romero-García
ResearchOpen Access01 Oct 2025
Nature Communications

Volume: 16, P: 1-13
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells

Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells. Here the authors show how this differentiation is controlled by tumor necrosis factor driving type 2 conventional dendritic cell-like reprogramming and IFN-I blocking it, a process that occurs during inflammation, injury and aging.

Rebeca Arroyo Hornero
Raul A. Maqueda-Alfaro
Juliana Idoyaga
ResearchOpen Access12 Aug 2025
Nature Immunology

Volume: 26, P: 1540-1552
Exploring levels of empathy and assertiveness in final year physiotherapy students during clinical placements

Juan-Elicio Hernández-Xumet
Alfonso‐Miguel García‐Hernández
Cristo-Manuel Marrero-González
ResearchOpen Access10 Jun 2024
Scientific Reports

Volume: 14, P: 1-18
Behavioural immune landscapes of inflammation

High-dimensional datasets derived from time-resolved live imaging of leukocytes in mice were used to identify leukocyte identities and dynamic neutrophil states with high cellular resolution.

Georgiana Crainiciuc
Miguel Palomino-Segura
Andrés Hidalgo
Research05 Jan 2022
Nature

Volume: 601, P: 415-421
The Helicobacter pylori AI-clinician harnesses artificial intelligence to personalise H. pylori treatment recommendations

Higgins et al. present an AI tool that uses patient data to personalise treatment for Helicobacter pylori, the leading agent of gastric cancer, demonstrating improved eradication rates over prescribed therapies in retrospective clinical analysis.

Kyle Higgins
Olga P. Nyssen
Kirill Veselkov
ResearchOpen Access14 Jul 2025
Nature Communications

Volume: 16, P: 1-12
Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5^−/− mice

RNF5 is a ubiquitin ligase regulating ER stress response. Here the authors show that Rnf5 deficiency potentiates immune response against melanoma via altered microbiota, and isolate bacterial strains that confer the same phenotype to wild type mice.

Yan Li
Roberto Tinoco
Ze’ev A. Ronai
ResearchOpen Access02 Apr 2019
Nature Communications

Volume: 10, P: 1-16
The Birth of a Relativistic Jet Following the Disruption of a Star by a Cosmological Black Hole

By modelling the radio, optical, UV and X-ray data of the unusually bright cosmological explosion AT 2022cmc, Pasham et al. argue for the presence of a highly collimated jet moving at ≳99.99% the speed of light.

Dheeraj R. Pasham
Matteo Lucchini
Sheng Yang
Research30 Nov 2022
Nature Astronomy

Volume: 7, P: 88-104
Protection against influenza infection requires early recognition by inflammatory dendritic cells through C-type lectin receptor SIGN-R1

In a mouse model of influenza virus infection, inflammatory dendritic cells are recruited to the infected trachea. Their activation through the C-type lectin receptor SIGN-R1 stimulates recruitment of natural killer cells and contributes to the control of viral replication.

Miguel Palomino-Segura
Laurent Perez
Santiago F. Gonzalez
Research29 Jul 2019
Nature Microbiology

Volume: 4, P: 1930-1940
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
CD137 (4-1BB) costimulation of CD8⁺ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation

Costimulation has been shown to be required for optimal activation of T cells and it could be delivered either in trans with respect to the source of CD3-TCR ligation or in cis on the same cell. Here the authors show that CD137 costimulation is more effective when delivered in cis to enhance T cell proliferation and activation.

Itziar Otano
Arantza Azpilikueta
Ignacio Melero
ResearchOpen Access15 Dec 2021
Nature Communications

Volume: 12, P: 1-15
The messy death of a multiple star system and the resulting planetary nebula as observed by JWST

JWST observations of the planetary nebula NGC 3132 reveal a rich molecular environment containing evidence of multiple stellar interactions on a variety of scales.

Orsola De Marco
Muhammad Akashi
Albert A. Zijlstra
Research08 Dec 2022
Nature Astronomy

Volume: 6, P: 1421-1432
MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

SMAD7 is a transcriptional target and a negative regulator of TGFβ signalling forming a negative feedback loop. Here the authors show that in cancer cells TGFβ activates the expression of microRNA-182 that suppresses SMAD7 protein, promoting TGFβ-mediated breast tumour invasion and bone metastasis.

Jingyi Yu
Rong Lei
Guohong Hu
ResearchOpen Access20 Dec 2016
Nature Communications

Volume: 7, P: 1-12
Durvalumab plus tremelimumab for the treatment of advanced neuroendocrine neoplasms of gastroenteropancreatic and lung origin

Single immune checkpoint blockade has shown limited activity in patients with neuroendocrine neoplasms (NENs). Here the authors report the results of a phase II clinical trial of durvalumab (anti-PD-L1) and tremelimumab (anti CTLA-4) in patients with advanced NENs of gastroenteropancreatic and lung origin.

J. Capdevila
J. Hernando
J. L. Manzano
ResearchOpen Access23 May 2023
Nature Communications

Volume: 14, P: 1-8
Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis

Raquel López-Mejías
Fernanda Genre
Miguel A. González-Gay
ResearchOpen Access18 Aug 2016
Scientific Reports

Volume: 6, P: 1-7
Author Correction: The messy death of a multiple star system and the resulting planetary nebula as observed by JWST

Orsola De Marco
Muhammad Akashi
Albert A. Zijlstra
Amendments and Corrections03 Jan 2023
Nature Astronomy

Volume: 7, P: 234
Targeting of epigenetic regulators in neuroblastoma

Luz Jubierre
Carlos Jiménez
Miguel F. Segura
ReviewsOpen Access27 Apr 2018
Experimental & Molecular Medicine

Volume: 50, P: 1-12
Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity

Genetic and Structural analysis of COVID patients cohort reveals a correlation between mitochondrial haplogroup and SARS-CoV-2 severity.

José Luis Cabrera-Alarcon
Raquel Cruz
José Antonio Enriquez
ResearchOpen Access09 Jan 2025
Communications Biology

Volume: 8, P: 1-12
SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L

Elena Coccia
Laura Planells-Ferrer
Joan X. Comella
ResearchOpen Access03 Feb 2020
Cell Death & Disease

Volume: 11, P: 1-19
Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming

The authors analyze time-resolved changes in genome topology, gene expression, transcription-factor binding, and chromatin state during iPSC generation. They conclude that 3D genome reorganization generally precedes gene expression changes and that removal of locus-specific topological barriers explains why pluripotency genes are activated sequentially during reprogramming.

Ralph Stadhouders
Enrique Vidal
Thomas Graf
Research15 Jan 2018
Nature Genetics

Volume: 50, P: 238-249
Polygenic risk modeling for prediction of epithelial ovarian cancer risk

Eileen O. Dareng
Jonathan P. Tyrer
Paul D. P. Pharoah
ResearchOpen Access14 Jan 2022
European Journal of Human Genetics

Volume: 30, P: 349-362
NAc-DBS selectively enhances memory updating without effect on retrieval

Andrés Pérez-Segura
Jorge Medina
Santiago Canals
ResearchOpen Access27 May 2025
Neuropsychopharmacology

Volume: 50, P: 1420-1429
Sensory deprivation in Staphylococcus aureus

Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. Here, the authors show that Staphylococcus aureus can survive in the absence of all its 16 TCSs under growth arrest conditions, and each TCS seems to be sufficient to sense and respond to specific environmental clues.

Maite Villanueva
Begoña García
Iñigo Lasa
ResearchOpen Access06 Feb 2018
Nature Communications

Volume: 9, P: 1-12
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality.

Luis A. Pérez-Jurado
Alejandro Cáceres
Juan R. González
ResearchOpen Access19 Feb 2024
Communications Biology

Volume: 7, P: 1-14
The antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosis

Laia París-Coderch
Aroa Soriano
Miguel F. Segura
ResearchOpen Access17 Sept 2020
Cell Death & Disease

Volume: 11, P: 1-10
Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality

Joaquín Martínez-López
María-Victoria Mateos
Jesús San-Miguel
ResearchOpen Access19 Oct 2020
Blood Cancer Journal

Volume: 10, P: 1-11
Neutrophil subtypes shape HIV-specific CD8 T-cell responses after vaccinia virus infection

Mauro Di Pilato
Miguel Palomino-Segura
Santiago F. Gonzalez
ResearchOpen Access12 Apr 2021
npj Vaccines

Volume: 6, P: 1-11
The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

The histone variant mH2A is shown to be expressed at reduced levels in many melanomas. Loss of mH2A promotes tumour growth and metastasis via transcriptional upregulation of CDK8, a known oncogene. This study therefore reveals a new tumour suppression mechanism exerted by epigenetic modifications.

Avnish Kapoor
Matthew S. Goldberg
Emily Bernstein
Research22 Dec 2010
Nature

Volume: 468, P: 1105-1109
Vaccination with BCGΔBCG1419c protects against pulmonary and extrapulmonary TB and is safer than BCG

Michel de Jesús Aceves-Sánchez
Mario Alberto Flores-Valdez
María Guadalupe Jorge-Espinoza
ResearchOpen Access14 Jun 2021
Scientific Reports

Volume: 11, P: 1-14
MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways

Blanca Majem
Alfonso Parrilla
Anna Santamaría
Research05 Jul 2019
Oncogene

Volume: 38, P: 6035-6050
MAP kinase ERK5 modulates cancer cell sensitivity to extrinsic apoptosis induced by death-receptor agonists

Sergio Espinosa-Gil
Saska Ivanova
José Miguel Lizcano
ResearchOpen Access02 Nov 2023
Cell Death & Disease

Volume: 14, P: 1-17
Copy number variants as modifiers of breast cancer risk for BRCA1/BRCA2 pathogenic variant carriers

The risk of germline copy number variants (CNVs) in BRCA1 and BRCA2 pathogenic variant carriers in breast cancer is assessed, with CNVs overlapping SULT1A1 decreasing breast cancer risk in BRCA1 carriers.

Christopher Hakkaart
John F. Pearson
Logan C. Walker
ResearchOpen Access06 Oct 2022
Communications Biology

Volume: 5, P: 1-15
Strategies of neutrophil diversification

Hidalgo and colleagues discuss general functional features of the neutrophil compartment that may be relevant in physiological scenarios such as specialization in naïve tissues, diversification and functional bias in inflammatory sites.

Miguel Palomino-Segura
Jon Sicilia
Andrés Hidalgo
Reviews23 Mar 2023
Nature Immunology

Volume: 24, P: 575-584
hpttg is over-expressed in pituitary adenomas and other primary epithelial neoplasias

Carmen Sáez
Miguel A Japón
José A Pintor-Toro
Research23 Sept 1999
Oncogene

Volume: 18, P: 5473-5476
Steroid hormone-related polymorphisms associate with the development of bone erosions in rheumatoid arthritis and help to predict disease progression: Results from the REPAIR consortium

Jose M. Sánchez-Maldonado
Rafael Cáliz
Juan Sainz
ResearchOpen Access15 Oct 2019
Scientific Reports

Volume: 9, P: 1-16
Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients

Luz M. Canet
Jose M. Sánchez-Maldonado
Juan Sainz
Research05 Oct 2018
The Pharmacogenomics Journal

Volume: 19, P: 83-96
PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas

Judith Navarro
Beatriz Gozalbo-López
José Yélamos
ResearchOpen Access09 Feb 2017
Scientific Reports

Volume: 7, P: 1-14
Low prevalence of SLX4 loss-of-function mutations in non-BRCA1/2 breast and/or ovarian cancer families

Gorka Ruiz de Garibay
Avellaneda Díaz
Miguel de la Hoya
Research05 Dec 2012
European Journal of Human Genetics

Volume: 21, P: 883-886
Expression of hpttg proto-oncogene in lymphoid neoplasias

Carmen Sáez
Teresa Pereda
Miguel A Japón
Research19 Nov 2002
Oncogene

Volume: 21, P: 8173-8177
Enhanced mGluR₅ intracellular activity causes psychiatric alterations in Niemann Pick type C disease

Ana Toledano-Zaragoza
Violeta Enriquez-Zarralanga
María Dolores Ledesma
ResearchOpen Access23 Oct 2024
Cell Death & Disease

Volume: 15, P: 1-13
A novel scale based on biomarkers associated with COVID-19 severity can predict the need for hospitalization and intensive care, as well as enhanced probabilities for mortality

Eduardo Nieto-Ortega
Alejandro Maldonado-del-Arenal
Alberto N. Peón
ResearchOpen Access04 Jun 2023
Scientific Reports

Volume: 13, P: 1-9
Regulation of aromatase expression in the anterior amygdala of the developing mouse brain depends on ERβ and sex chromosome complement

Carla Daniela Cisternas
Lucas Ezequiel Cabrera Zapata
María Julia Cambiasso
ResearchOpen Access13 Jul 2017
Scientific Reports

Volume: 7, P: 1-13
Estradiol-dependent axogenesis and Ngn3 expression are determined by XY sex chromosome complement in hypothalamic neurons

Carla Daniela Cisternas
Lucas Ezequiel Cabrera Zapata
María Julia Cambiasso
ResearchOpen Access19 May 2020
Scientific Reports

Volume: 10, P: 1-10
An in vivo microscopy dataset for the characterization of leukocyte death

Alain Pulfer
Diego Ulisse Pizzagalli
Santiago F. Gonzalez
ResearchOpen Access09 Apr 2025
Scientific Data

Volume: 12, P: 1-12
Characterization of complete lncRNAs transcriptome reveals the functional and clinical impact of lncRNAs in multiple myeloma

Arantxa Carrasco-Leon
Teresa Ezponda
Xabier Agirre
ResearchOpen Access17 Feb 2021
Leukemia

Volume: 35, P: 1438-1450
Real world outcomes of momelotinib in myelofibrosis patients with anemia: results from the MOMGEMFIN study

Lucía Pérez-Lamas
Adrián Segura Diaz
Valentín García Gutiérrez
CorrespondenceOpen Access17 Apr 2025
Blood Cancer Journal

Volume: 15, P: 1-6
Native bacteria isolated from roots and rhizosphere of Solanum lycopersicum L. increase tomato seedling growth under a reduced fertilization regime

María Micaela Pérez-Rodriguez
Patricia Piccoli
Ana Carmen Cohen
ResearchOpen Access24 Sept 2020
Scientific Reports

Volume: 10, P: 1-14
Agricultural and Physiological Responses of Tomato Plants Grown in Different Soilless Culture Systems with Saline Water under Greenhouse Conditions

Wilbert M. Rodríguez-Ortega
Vicente Martínez
Francisco García-Sánchez
ResearchOpen Access01 May 2019
Scientific Reports

Volume: 9, P: 1-13

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