Several exposures are required for protection from clinical malaria in endemic areas. Using the controlled human malaria infection model, Ferrer et al. here show that two exposures to Plasmodium falciparum infected mosquitoes induce partial preerythrocyte immunity in previously malaria naïve individuals. Immunity correlates positively with both anti-circumsporozoite protein antibody and CD69 + CD8 + T cell levels.
- Patricia Ferrer
- Andrea A. Berry
- Kirsten E. Lyke
