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Advanced filters: Author: Mingran Xie Clear advanced filters

  • Zhao et al. show that Akt-mediated phosphorylation of ubiquitin-fold modifier 1 (UFM1)-specific E3 ligase 1 (UFL1) catalyzes the UFMylation of ArpC4, a core subunit of actin-related proteins 2 and 3. Through ArpC4 UFMylation, UFL1 promotes lamellipodia formation and enhances cell migration, invasion and metastasis.

    • Kailiang Zhao
    • Hao Hu
    • Yide Mei
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 1528-1541