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Scientific Reports (24)
Oncogene (6)
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Showing 1–50 of 61 results

Advanced filters: Author: Minoru Fujita Clear advanced filters

Suppression of morphological transformation by radicicol is accompanied by enhanced gelsolin expression

Ho Jeong Kwon
Minoru Yoshida
Sueharu Horinouchi
Research20 Nov 1997
Oncogene

Volume: 15, P: 2625-2631
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Translocation-specific polymerase chain reaction in preimplantation genetic testing for recurrent translocation carrier

Gen Furukawa
Rie Kawamura
Hiroki Kurahashi
Research27 Feb 2025
Journal of Human Genetics

Volume: 70, P: 249-255
Decreased non-neurogenic acetylcholine in bone marrow triggers age-related defective stem/progenitor cell homing

The ability of bone marrow to recruit transplanted hematopoietic stem cells decreases with age. Here, the authors demonstrate that this decline is caused by reduced sinusoidal shear stress due to increased non-neuronal acetylcholine degradation.

Takayuki Morikawa
Shinya Fujita
Keiyo Takubo
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Correction: Corrigendum: Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

Yasuhito Yahara
Hiroshi Takemori
Noriyuki Tsumaki
Amendments and CorrectionsOpen Access27 Jun 2016
Nature Communications

Volume: 7, P: 1-2
Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis

Cardiac fibrosis is a hallmark of heart failure. Here the authors use single-cell RNA-sequencing, spatial transcriptomics, and genetic manipulations, to show that Htra3 regulates cardiac fibrosis by keeping fibroblasts quiescent and by degrading TGF-beta.

Toshiyuki Ko
Seitaro Nomura
Issei Komuro
ResearchOpen Access07 Jun 2022
Nature Communications

Volume: 13, P: 1-17
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II

Yunzeng Zou
Hiroshi Akazawa
Issei Komuro
Research16 May 2004
Nature Cell Biology

Volume: 6, P: 499-506
Effectiveness of third vaccine dose for coronavirus disease 2019 during the Omicron variant pandemic: a prospective observational study in Japan

Tetsuya Akaishi
Shigeki Kushimoto
Tadashi Ishii
ResearchOpen Access10 Aug 2022
Scientific Reports

Volume: 12, P: 1-7
Sialic acid-binding immunoglobulin-like lectin-15 expression on peritumoral macrophages is a favorable prognostic factor for primary central nervous system lymphoma patients

Hirotaka Fudaba
Yasutomo Momii
Minoru Fujiki
ResearchOpen Access13 Jan 2021
Scientific Reports

Volume: 11, P: 1-9
CRISPR-mediated activation of endogenous BST-2/tetherin expression inhibits wild-type HIV-1 production

Yanzhao Zhang
Seiya Ozono
Kenzo Tokunaga
ResearchOpen Access28 Feb 2019
Scientific Reports

Volume: 9, P: 1-8
Effects of Normothermic Conditioned Microwave Irradiation on Cultured Cells Using an Irradiation System with Semiconductor Oscillator and Thermo-regulatory Applicator

Mamiko Asano
Minoru Sakaguchi
Katsuyoshi Tabuse
ResearchOpen Access01 Feb 2017
Scientific Reports

Volume: 7, P: 1-11
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Here, Imamuraet al. conduct meta-analysis of genome-wide association studies to identify novel susceptibility loci for type 2 diabetes (T2D) in the Japanese population. By doing so, this study shows that both ethnicity-specific and ethnically-shared genetic loci can contribute to T2D risk.

Minako Imamura
Atsushi Takahashi
Takashi Kadowaki
ResearchOpen Access28 Jan 2016
Nature Communications

Volume: 7, P: 1-12
Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

Therapies are needed for the prevention of chondrocyte hypertrophy and thinning of articular cartilage, features of osteoarthritic joint destruction. Here, the authors show that interfering with Sik3 signalling can increase the size of the chondrocyte population and reduce severity of a surgically induced mouse model of osteoarthritis.

Yasuhito Yahara
Hiroshi Takemori
Noriyuki Tsumaki
ResearchOpen Access24 Mar 2016
Nature Communications

Volume: 7, P: 1-14
Statin treatment rescues FGFR3 skeletal dysplasia phenotypes

This study reprograms fibroblasts from thanatophoric dysplasia type I (TD1) and achondroplasia (ACH) patients into induced pluripotent stem cells (iPSCs), finding that chondrogenic differentiation results in the formation of degraded cartilage; statin treatment led to significant recovery of bone growth in a mouse model of ACH.

Akihiro Yamashita
Miho Morioka
Noriyuki Tsumaki
Research17 Sept 2014
Nature

Volume: 513, P: 507-511
Comparison of the Fractionation Efficiencies of Elution Method and Precipitation Chromatography of Polymer Fractionation

Minoru Ueda
Research01 Jul 1972
Polymer Journal

Volume: 3, P: 431-441
Prognostic significance of allelic losses in primary melanoma

Eugene Healy
Christine Belgaid
Jonathan L Rees
Research15 May 1998
Oncogene

Volume: 16, P: 2213-2218
Relationship between Blood Pressure and Chronic Kidney Disease in the Japanese Population: The Lower the Better Even in Individuals without Hypertension?

Yasutomi Higashikuni
Nobukazu Ishizaka
Minoru Yamakado
Research01 Feb 2008
Hypertension Research

Volume: 31, P: 213-219
TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513G>A mutation

Naoki Yahata
Yuji Matsumoto
Ryuji Hata
ResearchOpen Access14 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis

Satoshi Takagi
Yuki Sasaki
Ryohei Katayama
ResearchOpen Access23 Jul 2021
Oncogene

Volume: 40, P: 5548-5558
Identification and functional characterization of the extremely long allele of the serotonin transporter-linked polymorphic region

Tempei Ikegame
Yosuke Hidaka
Kazuya Iwamoto
ResearchOpen Access11 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-7
Chemical Modification of Pseurotin A: One-pot Synthesis of Synerazol and Pseurotin E and Determination of Absolute Stereochemistry of Pseurotin E

Minoru Ishikawa
Tomohisa Ninomiya
Correspondence01 Nov 2008
The Journal of Antibiotics

Volume: 61, P: 692-695
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Possible mechanism for improving the endogenous immune system through the blockade of peripheral μ-opioid receptors by treatment with naldemedine

Eizoh Gondoh
Yusuke Hamada
Minoru Narita
Research09 Aug 2022
British Journal of Cancer

Volume: 127, P: 1565-1574
The time variation of dose rate artificially increased by the Fukushima nuclear crisis

Masahiro Hosoda
Shinji Tokonami
Suminori Akiba
ResearchOpen Access07 Sept 2011
Scientific Reports

Volume: 1, P: 1-5
Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein – Barr virus

Hidetoshi Tahara
Yoshiki Tokutake
Masanobu Sugimoto
Research16 Oct 1997
Oncogene

Volume: 15, P: 1911-1920
Author Correction: TALEN-mediated shift of mitochondrial DNA heteroplasmy in MELAS-iPSCs with m.13513 G>A mutation

Naoki Yahata
Yuji Matsumoto
Ryuji Hata
Amendments and CorrectionsOpen Access13 Mar 2018
Scientific Reports

Volume: 8, P: 1
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins

Kenzo Tokunaga and colleagues report that MARCH8 inhibits the incorporation of the HIV-1 envelope glycoprotein into virus particles, thereby reducing viral infectivity.

Takuya Tada
Yanzhao Zhang
Kenzo Tokunaga
Research02 Nov 2015
Nature Medicine

Volume: 21, P: 1502-1507
Association of blood group O with a recurrent risk for acute lower gastrointestinal bleeding from a multicenter cohort study

Sho Suzuki
Naoyuki Tominaga
Naoyoshi Nagata
ResearchOpen Access17 Jun 2024
Scientific Reports

Volume: 14, P: 1-9
Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors

Takefumi Kikuchi
Minoru Toyota
Kohzoh Imai
Research24 Apr 2002
Oncogene

Volume: 21, P: 2741-2749
A novel prediction tool for mortality in patients with acute lower gastrointestinal bleeding requiring emergency hospitalization: a large multicenter study

Naoyuki Tominaga
Eiji Sadashima
Naoyoshi Nagata
ResearchOpen Access04 Mar 2024
Scientific Reports

Volume: 14, P: 1-14
Peculiar magnetotransport properties in epitaxially stabilized orthorhombic Ru³⁺ perovskite LaRuO₃ and NdRuO₃

Complex oxides are interesting for their potential to host multiple properties and functionalities by integrating different elements in a single compound, however they are often challenging to stabilize. Here, epitaxial stabilization of LaRuO₃ and NdRuO₃ is demonstrated, revealing an unconventional anomalous Hall effect in NdRuO₃ which is possibly related to a non-coplanar spin texture on the Nd³⁺ sublattice.

Lingfei Zhang
Takahiro C. Fujita
Masashi Kawasaki
ResearchOpen Access14 Mar 2024
Communications Materials

Volume: 5, P: 1-8
Synergistic involvement of the NZF domains of the LUBAC accessory subunits HOIL-1L and SHARPIN in the regulation of LUBAC function

Yusuke Toda
Hiroaki Fujita
Kazuhiro Iwai
ResearchOpen Access11 Nov 2024
Cell Death & Disease

Volume: 15, P: 1-11
Genetic basis of cardiomyopathy and the genotypes involved in prognosis and left ventricular reverse remodeling

Takashige Tobita
Seitaro Nomura
Issei Komuro
ResearchOpen Access31 Jan 2018
Scientific Reports

Volume: 8, P: 1-11
Secreted Ectodomain of SIGLEC-9 and MCP-1 Synergistically Improve Acute Liver Failure in Rats by Altering Macrophage Polarity

Takanori Ito
Masatoshi Ishigami
Akihito Yamamoto
ResearchOpen Access08 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits

Hayato Fujita
Kazuo Hara
Takashi Kadowaki
Research20 Sept 2012
Journal of Human Genetics

Volume: 57, P: 776-779
Outcomes in high and low volume hospitals in patients with acute hematochezia in a cohort study

Naoki Ishii
Naoyoshi Nagata
Mitsuru Kaise
ResearchOpen Access13 Oct 2021
Scientific Reports

Volume: 11, P: 1-10
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Roles for host and tumor angiotensin II type 1 receptor in tumor growth and tumor-associated angiogenesis

Nozomi Imai
Tatsuo Hashimoto
Satoshi Umemura
Research18 Dec 2006
Laboratory Investigation

Volume: 87, P: 189-198
Considerable scatter in the relationship between left atrial volume and pressure in heart failure with preserved left ventricular ejection fraction

Shiro Hoshida
Tetsuya Watanabe
Yasushi Matsumura
ResearchOpen Access09 Jan 2020
Scientific Reports

Volume: 10, P: 1-8
Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder

Chenyao Wang
Shin-ichiro Horigane
Norio Ozaki
ResearchOpen Access26 Feb 2022
Translational Psychiatry

Volume: 12, P: 1-12
Author Correction: Normothermic Microwave Irradiation Induces Death of HL-60 Cells through Heat-Independent Apoptosis

Mamiko Asano
Satoshi Tanaka
Katsuyoshi Tabuse
Amendments and CorrectionsOpen Access27 Apr 2018
Scientific Reports

Volume: 8, P: 1
Erratum: Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits

Hayato Fujita
Kazuo Hara
Takashi Kadowaki
Amendments and Corrections21 Dec 2012
Journal of Human Genetics

Volume: 57, P: 809

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