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Showing 1–8 of 8 results
Advanced filters: Author: Mitsuko Watabe-Uchida Clear advanced filters

  • During foraging with threat–reward conflicts in mice, dopamine modulates two competing neuron types in the striatum for flexible threat coping, from initial threat avoidance to eventual overcoming of the threat.

    • Iku Tsutsui-Kimura
    • Zhiyu Melissa Tian
    • Mitsuko Watabe-Uchida
    ResearchOpen Access
    Nature Neuroscience
    Volume: 28, P: 795-810

  • New data on brain-wide circuits centred around two interconnected hypothalamic neuron populations provide significant mechanistic insights into the emergence of social need during social isolation and the satiation of social need during social reunion.

    • Ding Liu
    • Mostafizur Rahman
    • Catherine Dulac
    ResearchOpen Access
    Nature
    Volume: 640, P: 1000-1010

  • The authors found that dopamine signals move gradually from time of reward to time of cue through intermediate timepoints, similarly to the evaluation signals used in temporal difference learning. These findings thereby fill a gap between computational theories and the brain.

    • Ryunosuke Amo
    • Sara Matias
    • Mitsuko Watabe-Uchida
    Research
    Nature Neuroscience
    Volume: 25, P: 1082-1092

  • Experiments using conditional RIM1 and RIM2 knockout mice and acute pharmacological manipulations clarify the role of rapid dopamine dynamics, whereby these dynamics are dispensable for movement initiation but important for reward-guided conditioned behaviours.

    • Xintong Cai
    • Changliang Liu
    • Pascal S. Kaeser
    Research
    Nature
    Volume: 635, P: 406-414

  • Sexual experience brings radical changes in how male mice behave with pups—virgin males attack them whereas mature fathers display parental care; here the authors identify a subset of hypothalamic neurons whose ablation leads to parental deficits in both males and females, and whose activation in virgin males suppresses aggression and induces pup grooming.

    • Zheng Wu
    • Anita E. Autry
    • Catherine G. Dulac
    Research
    Nature
    Volume: 509, P: 325-330

  • The AgRP-expressing neurons in the arcuate nucleus drive food-seeking behaviours during caloric restriction; a mouse study of monosynaptic retrograde rabies spread and optogenetic circuit mapping reveals that these neurons are activated by input from hypothalamic paraventricular nucleus cells and their activation or inhibition can modulate feeding behaviour.

    • Michael J. Krashes
    • Bhavik P. Shah
    • Bradford B. Lowell
    Research
    Nature
    Volume: 507, P: 238-242