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Showing 1–5 of 5 results
Advanced filters: Author: Moran Frenkel-Pinter Clear advanced filters

  • Origins-of-life research has focused on specific chemical reactions that might lead to biological molecules. Now an experimental model of chemical evolution based on oscillating water activity has been established. This system undergoes continuous chemical change, and demonstrates combinatorial compression, stringent chemical selection and synchronicity of molecular populations.

    • Kavita Matange
    • Vahab Rajaei
    • Moran Frenkel-Pinter
    Research
    Nature Chemistry
    Volume: 17, P: 590-597

  • One of the early processes enabling the origins of life is thought to be the condensation of building blocks into oligomers and polymers. In this article, the authors report the synthesis of thiodepsipeptides and HS-peptides under mild temperatures and various pH, suggesting they could have formed on early prebiotic Earth.

    • Moran Frenkel-Pinter
    • Marcos Bouza
    • Aikomari Guzman-Martinez
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-8

  • Cooperative relationships are widespread among different classes of biopolymers and are predicted to have existed during emergence of life. This study shows that proto-peptides engage in mutually stabilizing interactions with RNA, providing support for the co-evolution of these molecules.

    • Moran Frenkel-Pinter
    • Jay W. Haynes
    • Luke J. Leman
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Paul et al. provide a rational design strategy to develop dual inhibitors, in the form of tryptophan-galactosylamine conjugates, against amyloid formation and aggregation of Aβ42 and hIAPP peptides. These conjugates are not toxic to mammalian cells and reduce cytotoxicity of Aβ42 and hIAPP aggregates, hence potentially could serve as scaffolds for development of Alzheimer’s disease therapeutics.

    • Ashim Paul
    • Moran Frenkel-Pinter
    • Daniel Segal
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-12