Despite recent advances in primary sulfonamide synthesis, approaches using primary amines as starting points for direct sulfonamide construction remain elusive. Now a formal SO2 insertion into the C–N bond of primary amines has been developed, using an anomeric amide reagent for both C–N cleavage and S–N bond formation.
- Myojeong Kim
- Carys E. Obertone
- Mark D. Levin
