Elevated serum uric acid levels and gout are linked with the development of several comorbid conditions including hypertension, metabolic syndrome, chronic kidney disease and cardiovascular disease. In this Review, the authors explore the mechanisms underlying these associations and discuss the potential of appropriate treatment strategies to improve cardiovascular and renal outcomes in patients with hyperuricaemia and gout.
- Pascal Richette
- Fernando Perez-Ruiz
- Thomas Bardin