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Following a wide-ranging review of studies, reports and policies about nature’s multiple values, combinations of values-centred approaches are proposed to improve valuation of nature, address barriers to uptake in decision-making, and make transformative changes towards more just and sustainable futures.

A screening approach finds VH-domain antibodies that bind the SARS-CoV-2 Spike protein receptor-binding domain at its interface with host ACE2. Bi-paratopic and multivalent binders have high affinity and potency.

Fat-associated lymphoid clusters are lymphoid tissues that support B-1 cells. Caamaño and colleagues show that inflammation that elicits the cytokine TNF and activates natural killer cells contributes to the formation of these clusters in visceral fat.

The identification of antibodies targeting a conserved site of vulnerability in the Plasmodium falciparum circumsporozoite protein reveals opportunities for passive prevention of malaria in vulnerable individuals and provides insights for rational vaccine design.

MicroRNAs from head and neck cancer cells, shuttled to sensory neurons by extracellular vesicles, cause a shift to an adrenergic neuronal phenotype that promotes tumour progression.

Two below-threshold surface code memories on superconducting processors markedly reduce logical error rates, achieving high efficiency and real-time decoding, indicating potential for practical large-scale fault-tolerant quantum algorithms.

Telomerase deficiency leads to age-related diseases and shortened lifespan, while inhibition of the mTOR pathway delays aging. Here, the authors show that inhibition of mTORC1 signaling shortens the lifespan of telomerase deficient mice.

Several cases of replicated radiations (in which sets of similar forms evolve repeatedly within different regions) have been described in animals. Here the authors provide a well-documented example in plants, specifically the Oreinotinus lineage within the angiosperm clade Viburnum in its spread from Mexico to Argentina through disjunct cloud forest environments.

Physical realizations of qubits are often vulnerable to leakage errors, where the system ends up outside the basis used to store quantum information. A leakage removal protocol can suppress the impact of leakage on quantum error-correcting codes.

Diffuse large B-cell lymphoma is an aggressive heterogeneous tumour type with poorly understood aetiology. Here, Green et al. show that transient expression of Bcl6in haematopoietic stem cells is sufficient to induce mature B-cell lymphoma, indicating that it acts as a ‘hit-and-run’ oncogene.

Cutaneous squamous cell of the skin is a common neoplasm that frequently arises from precancerous actinic keratoses. Here, the authors carry out genomic analysis on matched sets of human lesions and compare with those in ultraviolet treated mice and identify conserved drivers of tumour development.

The magnetism produced by electrons in a solid can have two components — the spin and orbital moments — that are interchangeable on femtosecond timescales. Here it is shown how rapid changes in these two components can be disentangled, providing insights into the underlying dynamical processes that could be of value for the ultrafast control of information in magnetic recording media.

Genetic and Structural analysis of COVID patients cohort reveals a correlation between mitochondrial haplogroup and SARS-CoV-2 severity.

The impact of future and past carbonate chemistry changes on calcifying plankton is poorly understood. Here, the authors show that coccolithophore degree of calcification decreased significantly between 6 and 4 million years ago, in line with declining aqueous CO₂concentrations.

A nucleotide repeat expansion in C9orf72 is a common genetic cause of neurodegenerative disorders. Here, the authors provide insight into the molecular mechanism by which this repeat undergoes Repeat-Associated Non-AUG (RAN) translation, implicating the integrated stress response and eIF2α phosphorylation.

1000 Genomes imputation can increase the power of genome-wide association studies to detect genetic variants associated with human traits and diseases. Here, the authors develop a method to integrate and analyse low-coverage sequence data and SNP array data, and show that it improves imputation performance.

Linda Holmfeldt, Lei Wei et al. report whole-genome and exome sequencing of 40 childhood hypodiploid acute lymphoblastic leukemias.

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Combined analysis of proton-proton collision data from the Large Hadron Collider at CERN by the CMS and LHCb collaborations leads to the observation of the extremely rare decay of the strange B meson into muons; the result is compatible with the standard model of particle physics, and does not show any signs of new physics, such as supersymmetry.

The transcription factor Ikaros, which is essential for lymphocyte development, contains multiple zinc fingers. Smale and colleagues show that mice lacking different zinc fingers develop distinct lymphocyte-developmental defects and tumor susceptibility.

The growth of ice on Antarctica about 34 million years ago affected sea level. A combination of modelling and marine sediment analyses shows that sea level near the developing ice sheet first fell and then rose as a result of crustal deformation imposed by the ice growth.

A fluorescent sensor combining a mutated form of the 2-Cys peroxiredoxin Tsa2 unable to undergo thioredoxin-mediated reduction with a redox-sensitive GFP protein allows real-time detection of baseline hydrogen peroxide levels in yeast cells.

The East Antarctic ice sheet is considered to be largely insensitive to temperature changes in the Southern Ocean. Marine sediment records indicate the East Antarctic ice sheet repeatedly retreated by several hundred kilometres during intervals of Pliocene warmth.

A study demonstrating increasing error suppression with larger surface code logical qubits, implemented on a superconducting quantum processor.

The Southern Annular Mode (SAM) strongly impacts modern Southern Hemisphere climate, yet insight into its pre-industrial behaviour is lacking. Here, the authors present a high-resolution lake record and show that SAM variability coincided with major centennial-scale climate changes over the past 3,000 years.

A recording medium based on specially designed photorefractive polymers that combines a number of favourable properties is used to demonstrate an updateable holographic 3-dimensional display that is capable of recording and displaying new images every few minutes, has a significant size and can be viewed for several hours without the need for refreshing, as well as being able to be erased and updated with new images when desired.

Holographic displays can produce truly three-dimensional (3D) images, but have so far been unable to update images fast enough. These authors have adapted a previous technique, based on holographic stereographic recording with a photorefractive polymeric material as the recording medium, to produce a quasi-real-time holographic display that can refresh its images every two seconds, and use it to demonstrate the possibility of 3D telepresence. Improvements could bring applications in telemedicine, prototyping, advertising, updatable 3D maps and entertainment.

Using 13 functional traits we characterize the Amazonian trees and the communities they form. Amazonian tree communities are distributed along a fast-slow-spectrum. This results in clear differences in traits among these forests, as well as their biomass and biomass productivity.