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HIV-1 integrase forms an RNA-binding module on the luminal side of the mature capsid lattice.

From 2014–2017, marine heatwaves caused global mass coral bleaching, where the corals lose their symbiotic algae. The authors find, this event exceeded the severity of all prior global bleaching events in recorded history, with approximately half the world’s reefs bleaching and 15% experiencing substantial mortality.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Greenwald, Nederlof and colleagues developed a computational pipeline analyzing multiplex imaging data and established spatial patterns within breast cancer microenvironment that are predictive of immune checkpoint blockade response across treatment time course.

Ultra-compact phonon polariton devices may benefit from the atomically thin nature of van der Waals materials. Here, the authors report that atomically 2D transition metal dichalcogenides on a silicon carbide substrate support a 190-fold confinement of propagating surface phonon polaritons.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Large-scale growth of single crystals on graphene can be useful for the development of 3D/2D or 2D/2D heterostructures. Here, through careful control of growth kinetics, the authors perform multiple cycles of direct growth/transfer of high-quality single-crystal GaN, using a single graphene/SiC substrate.

Here the authors show that transient cell cycle arrest reprograms CD8⁺ T cells into a highly energized state, increasing proliferation and antitumor activity and boosting efficacy of immunotherapies in cancer models.

This paper uses multiomics to profile a large cohort of meningioma samples to highlight the role of the tumor microenvironment in driving the epigenetic changes underpinning tumor classification and prediction of outcome.

Wheat yields in northwest Europe have plateaued since the mid-1990s. This study finds that no ceiling in genetic yield potential has been reached and that climatic conditions have not constrained wheat yields across high-yielding environments in the region thus far; suboptimal agronomic management is responsible for unrealized wheat yield progress of 67–114 kg ha⁻¹ yr⁻¹ during the period 1994–2016.

De novo and inherited dominant variants in genes encoding U4 and U6 small nuclear RNAs are identified in individuals with retinitis pigmentosa. The variants cluster at nucleotide positions distinct from those implicated in neurodevelopmental disorders.

An optical method images nonlinear optical processes in waveguides with femtosecond and nanometre precision. The approach is used to achieve phase-matched second-harmonic generation in 3R-MoS₂ waveguides.

Treatment of Clostridioides difficile infections (CDI) with vancomycin is associated with high relapse rates. In this study, the experimental glycopeptide antibiotic EVG7 was found to effectively treat CDI without relapse in a murine model of recurrent CDI.

Plant traits drive ecosystem dynamics yet are challenging to map globally due to sparse measurements. Here, the authors combine crowdsourced biodiversity observations with Earth observation data to accurately map 31 plant traits at 1 km² resolution.

Cooling efficiency in thermoelectric devices decreases considerably at lower temperatures. Now thermoelectric cooling at cryogenic temperatures is directly imaged in a van der Waals semimetal.

Honeycomb lattices with interacting spins can host rich magnetic behaviour; however, typically features are complicated by additional interactions. Here, the authors perform neutron scattering on YbCl₃, which exhibits near perfect two-dimensional magnetism, providing a benchmark for other materials.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Natural hyperbolic materials retain the peculiar optical properties of traditional metamaterials whilst not requiring artificial structuring. Here, the authors perform a theoretical screening of a large class of natural materials with hyperbolic dispersion among the family of layered transition metal dichalcogenides.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Layered thio- and seleno-phosphate ferroelectrics show promise for next-generation memory but have thermal stability issues. Using the electric field-driven phase transition in antiferroelectric CuCrP2S6, the authors introduce a robust memristor, emphasizing the potential of van der Waals antiferroelectrics in advanced neuromorphic computing.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

89ZED88082A is a zirconium-89-labeled one-armed anti-CD8α antibody for the non-invasive whole-body visualization of CD8 + T-cells by positron emission tomography (PET). Here the authors report the results of a phase 2 study of 89ZED88082A for whole-body CD8 + T-cell PET imaging in patients with large B-cell lymphoma before and during CD19-directed CAR T-cell therapy.

Domain walls in van der Waals layered ferrielectric CuInP₂Se₆ exhibit piezoelectric response. This striking departure from traditional ferroelectric behavior is ascribed to a partially polarized antiferroelectric state, where the domain wall separates coexisting regions of ferrielectric and antiferroelectric phases.

Vaginal birth, exclusive breastfeeding and early contact with siblings promote colonization of the infant gut with bifidobacteria capable of producing aromatic lactates, a microbial and metabolite signal that is inversely related to the risk of allergen-specific sensitization and dermatitis later in life.

Coordinated X-ray and radio observations reveal that disk winds and jets occur mutually exclusively in 4U 1630–472, providing new observational constraints on the interplay between different modes of outflow in X-ray binaries.

Engineering polymerases to synthesize alternative genetic polymers remains a challenging problem in synthetic biology. The current study offers insights into the structural and biochemical changes responsible for improving the fidelity and catalytic activity of a laboratory evolved TNA polymerase.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Gravitational wave background offers insights into supermassive black hole binaries. Here, authors refine noise models in pulsar timing data to better understand the nanohertz gravitational wave background and find support to a population of slowly inspiraling binaries in circular orbits as its source.

Cas12a3 nucleases constitute a distinct clade of type V CRISPR–Cas bacterial immune systems that preferentially cleave the 3′ tails of tRNAs after recognition of target RNA to induce growth arrest and block phage dissemination.

The ability to tune spin-orbit interaction is crucial for spintronic and quantum devices. Alarab and colleagues use soft X-ray ARPES to show that this interaction in MoSe₂ can be strengthened by a proximity induced spin-orbit field transfer from a Pb layer deposited onto the MoSe₂ surface.

The mechanisms generating the head direction cell signal in rats are not fully understood. Here, two distinct types of head direction cells in the lateral mammillary and dorsal tegmental nuclei were identified: one type is angular head velocity independent, while the second type depends on the animal’s angular head velocity.

The two-dimensional atomic layers of black phosphorus may be exfoliated to create devices with desirable electronic transport properties. Here, the authors observe two-dimensional quantum transport in black phosphorus quantum wells, protected from oxidation by encapsulation in a polymer layer.

The atomic level core structure of dislocations in non-metallic materials such as chalcogenides remains elusive. Here, the authors combine atomic-resolution electron microscopy and simulations to image a dislocation core in bismuth telluride and show it spreads because of weak bonding between atomic layers.

Streptococcus thermophilus phages circumvent host CRISPR defences via AcrIIIA2, which complexes with enolase, a highly abundant glycolysis enzyme, to block phage RNA binding.

Morkovin’s hypothesis establishes a comparison between incompressible and compressible flows and is essential for understanding supersonic and hypersonic turbulence. In this work, the authors present the measurements of wall-normal fluctuations that support the hypothesis proposed in 1962.

Metallic resistance of two-dimensional electron gases normally increases with temperature increasing. Here, the authors find a resistance decrease with increasing temperature at very low temperatures in two-dimensional electron metal described by Fermi liquid theory.

Photonic technologies enable energy-efficient, high-speed computing, beyond electronics. The work shows nonlinear optical vector processing via linear transformations and wavelength multiplexing, for Hamming Distance and CAMs at 50 Gb/s, via silicon photonics.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Anisotropic hybridization between conduction and unpaired f electrons is rarely observed. Now, a lanthanide-based two-dimensional compound exhibits nodal hybridization, giving rise to heavy-fermion behaviour.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.