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Targeted clearance of extracellular Tau using aptamer-armed monocytes alleviates neuroinflammation in mice with Alzheimer’s disease

Monocytes derived from bone marrow leucocytes are chemically conjugated with a Tau-specific aptamer via bioorthogonal chemistry, enabling systemic delivery across the blood–brain barrier and targeted clearance of extracellular Tau in Alzheimer’s disease mouse models.

Yuting Zhuo
Yao Lu
Liping Qiu
Research01 Oct 2025
Nature Biomedical Engineering

P: 1-15
Pseudoexon activating by a deep intronic variant and phenotype variation in a Chinese family with dystrophinopathy

Xingyu Xia
Kexin Jiao
Wenhua Zhu
Research30 Jun 2025
Journal of Human Genetics

Volume: 70, P: 483-488
Harnessing organic electrolyte for non-corrosive and wide-temperature Na-Cl₂ battery

Rechargeable sodium-chlorine (Na-Cl₂) batteries hold promise for grid energy storage but face challenges of corrosive thionyl chloride (SOCl₂) electrolytes. Here, authors introduce a non-corrosive ester as an alternative, enabling Na-Cl₂ batteries with a wide temperature range from −40 to 80 °C.

Qiuchen Xu
Shanshan Tang
Hao Sun
ResearchOpen Access25 Feb 2025
Nature Communications

Volume: 16, P: 1-13
Author Correction: Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells

LiangYu Zhao
ChenCheng Yao
Zheng Li
Amendments and CorrectionsOpen Access18 Jun 2021
Nature Communications

Volume: 12, P: 1
Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells

Non-obstructive azoospermia affects 1% of men. Here, authors perform single-cell transcriptomic analysis of human testicular cells from healthy donors and non-obstructive azoospermia patients and find that inhibition of Wnt signaling promotes the maturation of Sertoli cells from patients.

LiangYu Zhao
ChenCheng Yao
Zheng Li
ResearchOpen Access10 Nov 2020
Nature Communications

Volume: 11, P: 1-15
Deep learning-driven hybrid model for short-term load forecasting and smart grid information management

Xinyu Wen
Jiacheng Liao
Yingxu Bao
ResearchOpen Access14 Jun 2024
Scientific Reports

Volume: 14, P: 1-16
Identification of a missense variant of MND1 in meiotic arrest and non-obstructive azoospermia

Jingpeng Zhao
Zhiyong Ji
Peng Li
Research26 Jun 2023
Journal of Human Genetics

Volume: 68, P: 729-735

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Targeted clearance of extracellular Tau using aptamer-armed monocytes alleviates neuroinflammation in mice with Alzheimer’s disease

Pseudoexon activating by a deep intronic variant and phenotype variation in a Chinese family with dystrophinopathy

Harnessing organic electrolyte for non-corrosive and wide-temperature Na-Cl2 battery

Author Correction: Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells

Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells

Deep learning-driven hybrid model for short-term load forecasting and smart grid information management

Identification of a missense variant of MND1 in meiotic arrest and non-obstructive azoospermia

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Harnessing organic electrolyte for non-corrosive and wide-temperature Na-Cl₂ battery