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Acute-on-chronic liver failure: pathophysiological mechanisms and clinical management

Acute-on-chronic liver failure (ACLF) is a complex syndrome characterized by acute hepatic decompensation superimposed on pre-existing chronic liver disease or cirrhosis. This Review provides an update on definitions, pathophysiological mechanisms, clinical presentation and management of ACLF.

S. K. Sarin
Ashok Choudhury
Constantine J. Karvellas
Reviews05 Jan 2026
Nature Reviews Gastroenterology & Hepatology

P: 1-21
Combined immune score of lymphocyte to monocyte ratio and immunoglobulin levels predicts treatment-free survival of multiple myeloma patients after autologous stem cell transplant

Karen Sweiss
Jonathan Lee
Pritesh R. Patel
Research16 Sept 2019
Bone Marrow Transplantation

Volume: 55, P: 199-206
Targeting lipid–protein interaction to treat Syk-mediated acute myeloid leukemia

A small molecule was developed that disrupted the lipid–SH2 domain interaction of the spleen tyrosine kinase (Syk), suppressed oncogenic activities in acute myeloid leukemia cell lines and was refractory to drug resistance.

Indira Singaram
Ashutosh Sharma
Wonhwa Cho
Research13 Oct 2022
Nature Chemical Biology

Volume: 19, P: 239-250
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation

A multiancestry genome-wide association study of chronic alanine aminotransferase elevation identifies candidate risk loci for nonalcoholic fatty liver disease, with replication in external cohorts defined by histology or imaging.

Marijana Vujkovic
Shweta Ramdas
Kyong-Mi Chang
Research02 Jun 2022
Nature Genetics

Volume: 54, P: 761-771
The Effect of Bariatric Surgery on Hypertension Outcomes: A Retrospective Cohort Study

Jesse E. Passman
Amanda Bader
Jordana B. Cohen
ResearchOpen Access20 Aug 2025
Journal of Human Hypertension

Volume: 39, P: 683-689

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Acute-on-chronic liver failure: pathophysiological mechanisms and clinical management

Combined immune score of lymphocyte to monocyte ratio and immunoglobulin levels predicts treatment-free survival of multiple myeloma patients after autologous stem cell transplant

Targeting lipid–protein interaction to treat Syk-mediated acute myeloid leukemia

A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation

The Effect of Bariatric Surgery on Hypertension Outcomes: A Retrospective Cohort Study

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