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Showing 1–5 of 5 results
Advanced filters: Author: Natasha E. Weiser Clear advanced filters

  • Extrachromosomal DNA makes cancerous tumours resistant to treatment, but this research demonstrates that increasing transcription–replication conflict allows for targeted elimination of cancer cells containing extrachromosomal DNA, and thus sustained tumour regression in mice.

    • Jun Tang
    • Natasha E. Weiser
    • Howard Y. Chang
    ResearchOpen Access
    Nature
    Volume: 635, P: 210-218

  • A study examines the diversity of extrachromosomal DNA elements in cancer, and provides details on the frequency and origin of extrachromosomal DNA and its role in the development of different types of cancer.

    • Chris Bailey
    • Oriol Pich
    • Charles Swanton
    ResearchOpen Access
    Nature
    Volume: 635, P: 193-200

  • Extrachromosomal DNA (ecDNA) congregates in clusters called ecDNA hubs that promote intermolecular interactions between gene-regulatory regions and thereby amplify the expression of oncogenes such as MYC in cancer cell lines.

    • King L. Hung
    • Kathryn E. Yost
    • Howard Y. Chang
    Research
    Nature
    Volume: 600, P: 731-736

  • CRISPR-CATCH is used to isolate extrachromosomal DNA (ecDNA) molecules containing oncogenes from human cancer cells. CRISPR-CATCH followed by nanopore sequencing allows for methylation profiling, highlighting differences from the native chromosomal loci.

    • King L. Hung
    • Jens Luebeck
    • Howard Y. Chang
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 1746-1754