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Showing 1–21 of 21 results
Advanced filters: Author: Nelson H. Knudsen Clear advanced filters

  • According to Fourier theory, thermal transport is a diffusive process. However, this cannot be the case at length scales smaller than the mean free path of the energy carriers. The first experimental study of thermal transport at the nanoscale is now reported in the case of a point-like heat source, providing a quantitative description of the transition between the ballistic and diffusive regimes.

    • Mark E. Siemens
    • Qing Li
    • Henry C. Kapteyn
    Research
    Nature Materials
    Volume: 9, P: 26-30

  • For over half a century, temperature wave was deemed exotic and mattered only at extremely low temperatures. Here, the authors reported direct observation of second sound, signature of the temperature wave, at a record-high temperature of over 200 K.

    • Zhiwei Ding
    • Ke Chen
    • Gang Chen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • The properties of chiral conjugated molecules, such as the absorption and/or emission of circularly polarized light or electron transport, are highly anisotropic. Now it has been shown that templating layers can control the orientation and anisotropic properties of small chiral molecules in bulk thin films useful for a range of emerging technologies.

    • Jessica Wade
    • Francesco Salerno
    • Matthew J. Fuchter
    Research
    Nature Chemistry
    Volume: 14, P: 1383-1389

  • An orally bioavailable small-molecule active-site inhibitor of the phosphatases PTPN2 and PTPN1, ABBV-CLS-484, demonstrates immunotherapeutic efficacy in mouse models of cancer resistant to PD-1 blockade.

    • Christina K. Baumgartner
    • Hakimeh Ebrahimi-Nik
    • Robert T. Manguso
    ResearchOpen Access
    Nature
    Volume: 622, P: 850-862

  • The dynamics of liquid water is rich due to its complex, highly disordered hydrogen-bond network, which hasn’t been fully understood. Perakis et al. measure water dynamics at sub-100 fs and show that it cannot be described by simple thermal motion due to the build-up of tetrahedral structures upon supercooling.

    • Fivos Perakis
    • Gaia Camisasca
    • Anders Nilsson
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • Three-dimensional photonic devices are of interest as light emitters, detectors or waveguides. However, so far their fabrication has remained a challenge. The template-directed epitaxy of three-dimensional semiconductor structures now offers a new strategy for the realization of photonic devices, demonstrated by the realization of a three-dimensional photonic crystal light-emitting diode.

    • Erik C. Nelson
    • Neville L. Dias
    • Paul V. Braun
    Research
    Nature Materials
    Volume: 10, P: 676-681

  • Using data gathered from the microphones of the Perseverance rover, the first characterization of the acoustic environment on Mars is presented, showing two distinct values for the speed of sound in CO2-dominated atmosphere.

    • S. Maurice
    • B. Chide
    • P. Willis
    ResearchOpen Access
    Nature
    Volume: 605, P: 653-658

  • Tissue nonspecific alkaline phosphatase (TNAP) within mitochondria hydrolyses phosphocreatine to initiate a futile cycle of creatine dephosphorylation and phosphorylation in thermogenic fat cells.

    • Yizhi Sun
    • Janane F. Rahbani
    • Bruce M. Spiegelman
    Research
    Nature
    Volume: 593, P: 580-585

  • Responses to anticancer therapy are hampered by several factors, and Peter S. Nelson and colleagues here identify a protective effect of the tumor microenvironment. After cytotoxic chemotherapy, inflammatory NF-κB signaling activates the secretion of WNT16B, which acts on epithelial cells, promoting their survival and fostering tumor growth in vivo. This pathway is also active in human tumors treated with chemotherapy and illustrates the potential caveats of cyclical therapy and the need to overcome environmental protection to successfully eliminate tumors.

    • Yu Sun
    • Judith Campisi
    • Peter S Nelson
    Research
    Nature Medicine
    Volume: 18, P: 1359-1368

  • A CRISPR–Cas9 screen of chromatin regulators in mouse tumour models treated with immune checkpoint blockade identifies SETDB1 as an epigenetic checkpoint protein that suppresses tumour-intrinsic immunogenicity.

    • Gabriel K. Griffin
    • Jingyi Wu
    • Bradley E. Bernstein
    Research
    Nature
    Volume: 595, P: 309-314

  • Here, the authors use genome-scale in vivo CRISPR screens to look at immune evasion mechanisms across cancer models, showing that IFN-mediated upregulation of classical and non-classical MHC class I inhibitory checkpoints facilitate immune escape.

    • Juan Dubrot
    • Peter P. Du
    • Robert T. Manguso
    Research
    Nature Immunology
    Volume: 23, P: 1495-1506

  • SenNet Consortium members review current and emerging methodologies for spatially resolved mapping of senescent cells. They discuss their limitations and challenges involved in the aim of creating a comprehensive atlas of senescent cells during aging.

    • Aditi U. Gurkar
    • Akos A. Gerencser
    • João F. Passos
    Reviews
    Nature Aging
    Volume: 3, P: 776-790

  • The Nordic region, comprising primarily Denmark, Estonia, Finland, Iceland, Norway and Sweden, has many of the necessary characteristics for being at the forefront of genome-based precision medicine. These include egalitarian and universal healthcare, expertly curated patient and population registries, biobanks, large population-based prospective cohorts linked to registries and biobanks, and a widely embraced sense of social responsibility that motivates public engagement in biomedical research. However, genome-based precision medicine can be achieved only through coordinated action involving all actors in the healthcare sector. Now is an opportune time to organize scientists in the Nordic region, together with other stakeholders including patient representatives, governments, pharmaceutical companies, academic institutions and funding agencies, to initiate a Nordic Precision Medicine Initiative. We present a roadmap for how this organization can be created. The Initiative should facilitate research, clinical trials and knowledge transfer to meet regional and global health challenges.

    • Pål Rasmus Njølstad
    • Ole Andreas Andreassen
    • Kári Stefánsson
    Comments & Opinion
    Nature Genetics
    Volume: 51, P: 924-930