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The northern high latitude permafrost region has been an important contributor to the carbon sink since the 1980s. A new study finds that as tree cover increases, respiratory CO2 loss during late-growing season offsets photosynthetic CO2 uptake and leads to a slower rate of increasing annual net CO2 uptake.

Federated learning can be used to train medical AI models on sensitive personal data while preserving important privacy properties; however, the sensitive nature of the data makes it difficult to evaluate approaches reproducibly on real data. The MedPerf project presented by Karargyris et al. provides the tools and infrastructure to distribute models to healthcare facilities, such that they can be trained and evaluated in realistic settings.

Declining Arctic sea ice is increasing polar bear land use. Here, the authors follow 20 different polar bears on land over 3 years and measure daily energy expenditure finding that despite behavioural and diet plasticity the bears are at risk of starvation.

The extent to which excess carbon dioxide causes a ‘fertilization effect’ varies across biomes and as a function of water supply, finds a study examining data from 14 CO₂ experimental sites.

Xu et al. show that satellite-measured urbanicity (living in a densely populated area) is correlated with brain volume, cortical surface area and brain network connectivity in a sample of 3,867 people from China and Europe.

Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined and the pathophysiology unknown. Here, the authors conduct deep phenotyping of a cohort of PI-ME/CFS patients.

By combining modelling and simulated data with empirical data from 76 grassland sites across 6 continents, the authors show that the relative abundance of dominant species predicts species richness, while their absolute abundance predicts community biomass.

Analysis of 97,691 high-coverage human blood DNA-derived whole-genome sequences enabled simultaneous identification of germline and somatic mutations that predispose individuals to clonal expansion of haematopoietic stem cells, indicating that both inherited and acquired mutations are linked to age-related cancers and coronary heart disease.

A reduction in the strength of the Atlantic Meridional Overturning Circulation initiated during the penultimate deglaciation led to excess polar ice losses, contributing to higher sea levels during the last interglacial period.

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

Many rocky planets formed with large, H2-rich atmospheres. Here, the authors show that the loss of these primary atmospheres from temperate planets such as TRAPPIST-1e typically leaves behind secondary atmospheres and habitable surface conditions.

The goals, resources and design of the NHLBI Trans-Omics for Precision Medicine (TOPMed) programme are described, and analyses of rare variants detected in the first 53,831 samples provide insights into mutational processes and recent human evolutionary history.

Wastewater surveillance could provide a means of monitoring SARS-CoV-2 prevalence that does not rely on testing individuals. Here, the authors report results from England’s national wastewater surveillance program, use it to estimate prevalence, and compare estimates with those from population-based prevalence surveys.

Susac syndrome is an inflammatory pathology of the brain endothelium. Here the authors show that the pathology is driven by CD8 T cells attacking the endothelium, and that blocking T cell-endothelial adhesion ameliorates the disease in a mouse model, and associates with improved clinical score in 4 patients.

Spatial variability in forest dieback during the severe drought in California between 2011 and 2017 can be explained by variations in bedrock composition and thus weatherability, according to analyses of the drought responses a series of geologically distinct sites.

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Numerical simulations suggest the wavelength of wind ripples is controlled by the mechanics of grain–bed impacts, not grain hop length, explaining why ripples on Mars and Earth are the same scale despite very different atmospheric conditions.

The late-stage functionalization of unactivated carbon–hydrogen bonds is a difficult but important task, which has been met with promising but limited success through synthetic organic chemistry. Here the authors use machine learning to engineer WelO5* halogenase variants, which led to regioselective chlorination of inert C–H bonds on a representative polyketide that is a non-natural substrate for the enzyme.

Observations from a borehole in the Kamb Ice Stream suggest that discrete subglacial discharge events dominate channel melt and sediment transport.

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

This study uses radio-echo sounding measurements, ice-core data and models to map the spatial variation in ice-crystal orientation in the northeast Greenland Ice Stream and shows how it potentially affects the ice-flow dynamics in this region.

Spatially resolved images of M87 obtained at a wavelength of 3.5 mm in 2018 show a ring-like accretion structure, the inner (outer) edge of which connects the black hole (jet).

Glacial meltwater from the Greenland Ice Sheet causes buoyancy-driven upwelling of nutrient-rich, subtropical waters from depth to the continental shelf. This nutrient transport may exceed the direct ice sheet inputs, according to geochemical analyses of transect samples from Sermilik Fjord.

Data from more than 200 million observations of plants, animals and fungi provide support for the concept that terrestrial biodiversity patterns reflect distinct ecoregions.

Wood density is an important plant trait. Data from 1.1 million forest inventory plots and 10,703 tree species show a latitudinal gradient in wood density, with temperature and soil moisture explaining variation at the global scale and disturbance also having a role at the local level.

Pooling participant-level genetic data into a single analysis can result in variance stratification, reducing statistical performance. Here, the authors develop variant-specific inflation factors to assess variance stratification and apply this to pooled individual-level data from whole genome sequencing.

The response time of North Atlantic climate to changes in high-latitude deep-water formation during the last deglaciation is still unclear. Here the authors show that gradual changes in Nordic Seas deep-water circulation systematically lead ahead of abrupt regional climate shifts by ~400 years.

Analyses of over 700,000 satellite images to map the global extent of tidal flats over the past thirty years, and enable assessments of the status and likely future trajectories of these coastal ecosystems.

Examining drivers of the latitudinal biodiversity gradient in a global database of local tree species richness, the authors show that co-limitation by multiple environmental and anthropogenic factors causes steeper increases in richness with latitude in tropical versus temperate and boreal zones.

There is much uncertainty on the response of soil microbial communities to warming, particularly in the subsoil. Here, the authors investigate microbial community and metabolism response to 4.5 years of whole-profile soil warming, finding depth-dependent effects and elevated subsoil microbial respiration.

A sequencing chemistry that separates nucleotide identification from nucleotide incorporation achieves high accuracy.

A study shows that clonal haematopoiesis of indeterminate potential is associated with an increased risk of chronic liver disease specifically through the promotion of liver inflammation and injury.

This Perspective presents a wetting regime framework that is classified by dominant hydrologic mechanisms and highlights the resulting responses of stream biogeochemistry and community ecology.

Over the past century, the Western Antarctic Peninsula has experienced rapid warming and a substantial loss of sea ice with important implications for plankton biodiversity and carbon cycling. Using a 5-year DNA metabarcoding dataset, this study assesses how interannual variability in sea-ice conditions impacts biodiversity and biological carbon fluxes in this region.

The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus.

The ~70 km-diameter Yarrabubba impact structure in Western Australia has previously been regarded as among Earth’s oldest meteorite craters, but has hitherto lacked absolute age constraints. Here, the authors determine a precise impact age of 2229 ± 5 Ma, which extends the terrestrial cratering record back in time by > 200 million years and establishes Yarrabubba as the oldest recognised meteorite impact structure on Earth.

The presence of gaseous chlorine atom precursors within the troposphere was thought only to occur in marine areas but now nitryl chloride has been found at a distance of 1,400 km from the nearest coastline. A model study shows that the amount of nitryl chloride production in the continental USA alone is similar to previous global estimates for marine regions. A significant fraction of tropospheric chlorine atoms may arise directly from anthropogenic pollutants.

Most studies of the genetics of the metabolome have been done in individuals of European descent. Here, the authors integrate genomics and metabolomics in Black individuals, highlighting the value of whole genome sequencing in diverse populations and linking circulating metabolites to human disease.

Although the common genetic variants contributing to blood lipid levels have been studied, the contribution of rare variants is less understood. Here, the authors perform a rare coding and noncoding variant association study of blood lipid levels using whole genome sequencing data.

Platelet aggregation is associated with myocardial infarction and stroke. Here, the authors have conducted a whole genome sequencing association study on platelet aggregation, discovering a locus in RGS18, where enhancer assays suggest an effect on activity of haematopoeitic lineage transcription factors.

Examination of the effects of three new drugs shows that the destruction of the immune system in AIDS reflects fulminant HIV production, which eventually overwhelms the immune system's prodigious powers of regeneration.

Contributions of iron sources to Southern Ocean CO₂sequestration during the last glacial period remain uncertain. Here, based on the biogeochemical analysis of subglacial calcites, the authors propose Antarctic volcanism, via subglacial drainage of Fe-rich waters, as a key contributor.