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Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice

François Nantel
Lucia Monaco
Paolo Sassone-Corsi
Research14 Mar 1996
Nature

Volume: 380, P: 159-162
Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report

Remdesivir is under evaluation for treatment of COVID-19 in clinical trials. Here, the authors report results of remdesivir treatment in a patient with COVID-19 and the genetic antibody deficiency XLA. They show a temporally correlated clinical and virological response, suggesting that remdesivir can reduce SARS-CoV-2 replication in patients.

Matthew S. Buckland
James B. Galloway
James E. D. Thaventhiran
ResearchOpen Access14 Dec 2020
Nature Communications

Volume: 11, P: 1-11
A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice

Interactions between the host immune response and the commensal microbiota play essential roles in health and disease. Here the authors identify a population of MHC class II, innate like, commensal reactive cells in the gut of mice and humans.

Carl-Philipp Hackstein
Dana Costigan
Emily E. Thornton
ResearchOpen Access03 Dec 2022
Nature Communications

Volume: 13, P: 1-19
Single-cell integration reveals metaplasia in inflammatory gut diseases

The study provides a comprehensive transcriptomic atlas of the human gastrointestinal tract across the lifespan, highlighting inflammation-induced changes in epithelial stem cells that alter mucosal architecture and promote further inflammation.

Amanda J. Oliver
Ni Huang
Sarah A. Teichmann
ResearchOpen Access20 Nov 2024
Nature

Volume: 635, P: 699-707
Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease

FitzPatrick et al. use single-cell RNA and spatial transcriptomics to dissect the immune microenvironments within the small bowel mucosa in celiac disease.

Michael E. B. FitzPatrick
Agne Antanaviciute
Paul Klenerman
ResearchOpen Access06 May 2025
Nature Immunology

Volume: 26, P: 947-962
T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses

Understanding the immune response to SARS-CoV-2 is dependent on being able to distinguish COVID-19 immune responses from cross-reactive immune responses to other coronaviruses. Here the authors show that choice of antigens and whether an ICS, ELISPOT or T cell proliferation assay is used has a major effect on this discriminatory ability.

Ane Ogbe
Barbara Kronsteiner
Susanna Dunachie
ResearchOpen Access06 Apr 2021
Nature Communications

Volume: 12, P: 1-14
Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity

Garner et al. analyzed the single-cell transcriptome and TCR repertoire of matched blood and liver, and resting and activated, human MAIT cells. They identify donor-specific TCR repertoires shared across tissues and a transcriptome that is largely homogeneous at rest, but highly adaptive to different tissue and stimulation environments.

Lucy C. Garner
Ali Amini
Paul Klenerman
ResearchOpen Access14 Aug 2023
Nature Immunology

Volume: 24, P: 1565-1578
Adenovirus vector vaccination reprograms pulmonary fibroblastic niches to support protective inflating memory CD8⁺ T cells

Ludewig and colleagues show that adenovirus immunization fosters the formation of pulmonary immune-stimulating niches underpinned by fibroblastic stromal cells that maintain ‘inflating’ memory CD8⁺ T cells through the provision of interleukin-33.

Jovana Cupovic
Sandra S. Ring
Burkhard Ludewig
Research15 Jul 2021
Nature Immunology

Volume: 22, P: 1042-1051
Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Amendments and Corrections21 May 2021
Nature Medicine

Volume: 27, P: 1116
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection.

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 270-278
SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease

Serological analysis and infection outcomes of participants in the multi-center, prospectively enrolled OCTAVE cohort, comprising 2,686 participants with immune-suppressive diseases who recieved two COVID-19 vaccines, reveals specific clinical phenotypes that might benefit from specific COVID-19 therapeutic strategies.

Eleanor Barnes
Carl S. Goodyear
Deborah Richardson
ResearchOpen Access06 Jul 2023
Nature Medicine

Volume: 29, P: 1760-1774
The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity

The clinical HDAC inhibitor zabadinostat increases MHC class I and II expression in dendritic cells, activates T and B cells, and enhances adaptive immune responses to COVID-19 spike protein in mice.

Geng Liu
Wojciech Barczak
Nicholas B. La Thangue
ResearchOpen Access26 Jan 2023
Communications Biology

Volume: 6, P: 1-14

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