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Certifying multipartite entanglement can benchmark quantum devices. Here, authors introduce versatile tests that can certify genuine multipartite entanglement and k-inseparability using only few-body measurements, enabling noise-robust benchmarking of large photonic and superconducting graph states.

This systematic review analyzes how income and educational attainment are reported in psychedelic-assisted therapy trials. It reveals that only a minority of trials report this information and, when reported, the data have considerable variation in format and ambiguity in details. It also reveals disparities, with participants having higher income and being highly educated overrepresented in trials.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Two algal proteins, MITH1 and SAGA1, play key roles in formation of membranes that deliver CO₂ to the pyrenoid, a CO₂-concentrating organelle. Their discovery marks a key milestone towards engineering a pyrenoid into land plants for improved yields.

The function of circular RNAs in the brain remains poorly understood. Here the authors identify a role for circular RNAs in the control of neuron morphology and migration in the developing midbrain dopamine system.

Introducing the pyrenoid-based CO2-concentrating mechanism of green algae into crops could greatly improve photosynthesis. Here, the authors show that expression of the algal linker protein EPYC1 and a plant-algal hybrid Rubisco in Arabidopsis chloroplasts leads to formation of a phase separated algal-like proto-pyrenoid.

Researchers hope that the antibody-laden blood of those who have recovered from coronavirus might reduce severe infections — but we don’t know yet if it will work. Plus: signs that the outbreak in Italy went undetected for weeks, and how running a quantum computer is like solving a Rubik’s Cube blindfolded.

Intranasal administration of oxytocin is increasingly considered as a new therapeutic option for alleviating stress and social problems in children with autism. Here, important insights are provided into how repeated administration of oxytocin influences the functioning of one’s own oxytocin system.

NOTUM from Apc-mutant cells acts as a key mediator during the early stages of mutation fixation and drives the formation of intestinal adenomas.

Examine the shaky evidence for the efficacy of a decades-old antimalarial against coronavirus. Plus: Canada begins the world’s largest clinical trial of survivors’ blood to treat COVID-19, and celebrating the life of astrophysicist Margaret Burbidge, who traced the origin of everything to the hearts of stars.

Utilizing short-term dietary interventions for surgical preconditioning stands as an emerging approach to enhance surgical outcomes. Here, the authors show the potential of short-term preoperative methionine restriction as a simple intervention to ameliorate postinterventional vascular remodelling.

Overturning circulation that mixes surface and deep water was invariant over the Holocene, suggesting a limited role in rising CO₂ during this time, according to deep-sea coral radiocarbon records.

V-shaped ridges of thickened oceanic crust above the Iceland plume are thought to record variations in the convection of the mantle below. Geochemical analyses of basalt samples taken from the ridges suggest the thickened crust formed as the result of blobs of hot mantle rising up in the underlying plume.

Hot mantle upwelling in the Icelandic plume has caused episodic uplift of sedimentary basins located off the northwest coast of Europe. Reconstruction of river profiles on an ancient buried landscape constrains the history of surface uplift and suggests that pulses of hot plume material spread out at velocities of 35 cm yr⁻¹.

The levels of 1,251 metabolites are measured in 475 phenotyped individuals, and machine-learning algorithms reveal that diet and the microbiome are the determinants with the strongest predictive power for the levels of these metabolites.

Intermediate-length repeat expansions in ATXN-2 are the strongest genetic risk factor for ALS. Here, the authors combine patient-derived motor neurons and organoids with mouse models to dissect the pathogenic effects of ATXN2 intermediate expansions.

Septic costochondritis is a rare presentation that is usually seen in intravenous drug users, patients with diabetes or those receiving long-term hemodialysis. In this Case Study, the authors describe the diagnosis and management of this condition in a previously healthy patient without any of the established risk factors.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Existing methods for non-invasively monitoring water flow in plants have limited spatial/temporal resolution. Here, the authors report that Raman microspectroscopy, complemented by hydrodynamic modelling, can monitor hydrodynamics within living root tissues at cell- and sub-second-scale resolutions.

Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.

Green leaf volatiles are emitted from plants in response to stress. Here the authors identify an isomerase in Manduca sexta that both modulate plant green leaf volatiles and functions in insect development.

Analysing data from 64,305 Holocene pollen samples worldwide, the authors reveal regionally variable long-term diversity trends associated with human impact over the last 8,000 years.

The subsynaptic organization of group I mGluRs modulates their activation and downstream signaling, essential for synaptic transmission and plasticity. Here, the authors describe how the C-terminal domain of mGluR5 controls its dynamic organization in perisynaptic nanodomains, and prevents mGluR5 form entering the synapse, allowing mGluR5 to finely tune synaptic signalling.

A prespecified secondary endpoint from the TriMaster study demonstrates that after trying three different classes of diabetes medications most patients preferentially selected the drug that was associated with the best glycemic control on an individual level.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

The structural basis of the interactions between Rubisco and its intrinsically disordered linker protein provides insight into phase separation within the algal pyrenoid, an organelle responsible for around a third of global CO₂ fixation.

Nano-environmental probes and advance imaging microscopy provide deep insight into protein phase separation and the interaction of condensates with membranes, revealing that wetting by condensates can modulate membrane lipid packing and hydration.

Nature reported from marches in cities including Sydney, Washington DC and Paris, as people took to the streets in support of science.

A giant iceberg, a quantum-entanglement experiment and the death of a spacecraft are among the year’s top stories.

The bacterial genus Rickettsia includes vector-borne pathogens and arthropod symbionts that are close relatives of symbionts of microeukaryotes classified under the genus ‘Candidatus Megaira’. Here, Davison et al. clarify the evolutionary relationships between these organisms by assembling 28 genomes of understudied species, and propose that a distinct clade known as Torix Rickettsia should be considered a separate genus.

In mouse and human squamous cell carcinoma, loss of function of FAT1 promotes tumour initiation, malignant progression and metastasis through the activation of a hybrid epithelial-to-mesenchymal transition phenotype.

The use of natural killer (NK) cells in immunotherapy as an alternative to allogeneic T cells is gaining ground. Here, two genome-scale high-throughput platforms are used to identify genes that modulate the sensitivity of multiple solid tumor cell lines to NK-mediated killing.

Brain organoid models reported to date lack cells of mesodermal origin, such as microglia. Here, the authors demonstrate that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human microglia in a three-dimensional brain environment.

Ridges on the seafloor near Iceland form when hot mantle pulses through an underlying plume. Seismic data show that the frequency of ridge formation decreased about 35 million years ago implying a change in the thermal state of the plume source.

Epithelial-to-mesenchymal transition in tumour cells occurs through distinct intermediate states, associated with different metastatic potential, cellular properties, gene expression, and chromatin landscape

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Tectonic plate interiors are often regarded as relatively inactive. Yet, reconstructions of marine terrace uplift in Angola suggest that underlying mantle flow can rapidly warp Earth's surface far from obviously active plate boundaries.

Clinical multi-omics data are integrated and analyzed using a generative deep-learning model.

Many genetic variants have been associated with human traits, but the mechanism is often unknown. Here, the authors integrate local and distal genetic associations with multi-omics datasets to provide a roadmap to understand the underlying mechanisms of GWAS variants on complex traits.

Local communities and geneticists are working together to sequence DNA from remains that were taken from their homelands decades ago.

Glaciers are retreating with global climate warming, which threatens glacier specialists and the functions and stability of glaciers and glacially influenced ecosystems. This Review describes the impacts and consequences of glacier retreat for biodiversity, highlighting species that are likely to thrive or decline with glacier loss, and outlines key challenges and research priorities in conserving and managing biodiversity.