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Showing 1–5 of 5 results
Advanced filters: Author: Nico Dissmeyer Clear advanced filters

  • PRT1 is an E3 ligase that recognizes type-2 hydrophobic aromatic Arg/N-degrons. Here, the authors reveal the structure of the ZZ domain of Arabidopsis PRT1 bound to bulky hydrophobic type-2 N-degrons, showing a unique binding site formed by a substantial conformational change of two loops and uncovering an intramolecular tandem RING dimer essential for its ubiquitylation activity.

    • Woo Seok Yang
    • Seu Ha Kim
    • Hyun Kyu Song
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Switching target protein accumulation and activity by portable conditional degrons is potentially useful for both basic research and bioengineering. Here the authors present a versatile system to tune protein levels in live animals and plants using a temperature-sensitive N-end rule degradation signal.

    • Frederik Faden
    • Thomas Ramezani
    • Nico Dissmeyer
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15

  • The N-end rule pathway targets substrate proteins for proteasomal degradation. Here, Whiteet al. show that ArabidopsisPLANT CYSTEINE OXIDASEs show dioxygenase activity producing Cys-sulfinic acid at the N-terminus of target proteins, which then act as direct substrates for arginyl transferase.

    • Mark D. White
    • Maria Klecker
    • Emily Flashman
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Contributions from both parents are usually needed to produce viable offspring, in plants as well as animals. Nowack et al. explore the pathways controlling this process in plants by producing seeds containing only maternal endosperm— only possible when certain FIS class mutations are present in the maternal line — that grow into viable but smaller plants.

    • Moritz K. Nowack
    • Reza Shirzadi
    • Arp Schnittger
    Research
    Nature
    Volume: 447, P: 312-315