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Showing 1–2 of 2 results
Advanced filters: Author: Nicole Pandell Clear advanced filters

  • Despite improving therapeutic options, the prognosis for patients with metastatic castration-resistance prostate cancer (mCRPC) remains poor. Here, the authors identify MCL1 copy number alterations as a prognostic and predictive biomarker, demonstrating its therapeutic potential as a drug target, either alone or in combination, in patients with mCRPC.

    • Juan M. Jiménez-Vacas
    • Daniel Westaby
    • Adam Sharp
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22

  • Maroni, Bassal, Krishnan et al. characterise human non-small cell lung cancer (NSCLC) carrying Kras-mutations by single-cell RNA sequencing. They identify a tumour-specific population that is conserved in mice and responds to the drug, PTC596, which is currently in clinical trials and may offer a potential avenue for treating aggressive NSCLC expressing mutated Kras.

    • Giorgia Maroni
    • Mahmoud A. Bassal
    • Elena Levantini
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15