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Showing 1–3 of 3 results
Advanced filters: Author: Ningyi Zhong Clear advanced filters

  • Lipase is one of the most important industrial biocatalysts with wide applications, but its catalytic efficiency is often hindered by a closed lid conformation. Here, the authors present an aggregation-induced conformation locking strategy that enables the facile synthesis of highly activated lipase hybrid biocatalysts.

    • Anlian Huang
    • Zhi-Wei Li
    • Gangfeng Ouyang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13

  • Expression of TET1 dioxygenase, which catalyzes the conversion of 5-methylcytosine to 5-hydroxymethylcytosine, is downregulated by repeated cocaine administration in mouse nucleus accumbens, where it controls cocaine reward. Genome-wide mapping of 5-hydroxymethylcytosine in this brain region reveals novel modes of epigenetic regulation by cocaine.

    • Jian Feng
    • Ningyi Shao
    • Eric J Nestler
    Research
    Nature Neuroscience
    Volume: 18, P: 536-544

  • Metformin is a medication for type 2 diabetes but little is known about the fate of metformin by microbial catabolism. Here the authors characterize a Ni2 + -dependent heterohexameric enzyme MetCaCb from the ureohydrolase superfamily, catalyzing the hydrolysis of metformin into guanylurea and dimethylamine.

    • Tao Li
    • Zhi-Jing Xu
    • Ning-Yi Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10