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Advanced filters: Author: Noble Kumar Talari Clear advanced filters

Lipid-droplet associated mitochondria promote fatty-acid oxidation through a distinct bioenergetic pattern in male Wistar rats

How the liver mitochondria seamlessly regulate lipogenesis and lipid oxidation is unknown. Here, the authors report two functionally distinct populations of mitochondria, cytoplasmic and lipid droplet-associated mitochondria, and demonstrate that the latter’s lipid oxidation function is impaired in a rat NAFLD model.

Noble Kumar Talari
Ushodaya Mattam
Naresh Babu V. Sepuri
ResearchOpen Access11 Feb 2023
Nature Communications

Volume: 14, P: 1-14
Functional compartmentalization of hepatic mitochondrial subpopulations during MASH progression

Isolation and characterisation of hepatic cytoplasmic (CM) and peridroplet mitochondria (PDM) from simple steatosis to advanced MASH. PDM showed higher pyruvate oxidation and OXPHOS, while CM favored fatty acid oxidation with MASH progression.

Noble Kumar Talari
Ushodaya Mattam
Karthickeyan Chella Krishnan
ResearchOpen Access18 Feb 2025
Communications Biology

Volume: 8, P: 1-13
Mammary duct luminal epithelium controls adipocyte thermogenic programme

In mice, sympathetic nerves associated with female mammary glands control the secretion of thermogenesis-controlling factors by epithelial cells in the adipocyte niche, revealing sex-specific differences in adipose thermogenesis.

Sanil Patel
Njeri Z. R. Sparman
Prashant Rajbhandari
Research26 Jul 2023
Nature

Volume: 620, P: 192-199

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