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Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist

Melanocortin-4 receptor (MC4R) is key in controlling hunger. Here, authors discover the MC4R-specific, potent agonist nanobody pN162. The pN162-MC4R-Gs-Nb35 structure shows its distinct binding mode compared to peptide agonists.

Thomas Fontaine
Andreas Busch
Christel Menet
ResearchOpen Access01 Oct 2024
Nature Communications

Volume: 15, P: 1-14

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Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist

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