Nature Search

Preparation and Mounting of Deliquescent Substances

NORA WOOSTER
A. J. P. MARTIN
Research16 Apr 1932
Nature

Volume: 129, P: 582
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
KidneyGenAfrica, a pan-African partnership to deliver research and training excellence in genomics of kidney disease

Despite Africa’s vast genetic diversity, its populations are underrepresented in global genomic datasets. Here we describe the vision of the KidneyGenAfrica, a pan-African initiative launched to address this inequity, and call for more inclusive genomics research that recognizes Africa’s key role in genetic variation and potential to generate insights in chronic kidney disease.

Segun Fatumo
Oyesola Ojewunmi
June Fabian
Comments & Opinion20 Aug 2025
Nature Genetics

Volume: 57, P: 2079-2082
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

A multi-ancestry genome-wide gene–smoking interaction study identifies 13 new loci associated with serum lipids.

Amy R. Bentley
Yun J. Sung
L. Adrienne Cupples
Research29 Mar 2019
Nature Genetics

Volume: 51, P: 636-648
Kidney health outcomes of hypertensive disorders of pregnancy

This Review examines the bidirectional relationship between hypertensive disorders of pregnancy and kidney disease, which is currently underrecognized, with potential long-term implications for kidney health in both mothers and their offspring. The authors also discuss prevention and management of hypertensive disorders of pregnancy, including kidney health follow-up, and current research gaps.

Giorgina Barbara Piccoli
Massimo Torreggiani
Vesna D. Garovic
Reviews18 Jul 2025
Nature Reviews Nephrology

Volume: 21, P: 671-686
Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury

Clonal hematopoiesis, which increases with age and is implicated in a variety of age-related diseases, is shown here to be associated with a greater risk of acute kidney injury and worse outcome following injury, as demonstrated using multiple patient cohorts, Mendelian randomization analysis and mechanistic studies in mouse disease models.

Caitlyn Vlasschaert
Cassianne Robinson-Cohen
Alexander G. Bick
ResearchOpen Access07 Mar 2024
Nature Medicine

Volume: 30, P: 810-817
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of four genetic loci on HDL or LDL cholesterol.

Tuomas O. Kilpeläinen
Amy R. Bentley
Ruth J. F. Loos
ResearchOpen Access22 Jan 2019
Nature Communications

Volume: 10, P: 1-11
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Associations of autozygosity with a broad range of human phenotypes

Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

David W Clark
Yukinori Okada
James F Wilson
ResearchOpen Access31 Oct 2019
Nature Communications

Volume: 10, P: 1-17
Shared heritability and functional enrichment across six solid cancers

Similarities in cancers can be studied to interrogate their etiology. Here, the authors use genome-wide association study summary statistics from six cancer types based on 296,215 cases and 301,319 controls of European ancestry, showing that solid tumours arising from different tissues share a degree of common germline genetic basis.

Xia Jiang
Hilary K. Finucane
Sara Lindström
ResearchOpen Access25 Jan 2019
Nature Communications

Volume: 10, P: 1-23
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups

Cross-disorder genetic association analyses identify five loci differentiating attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Individuals diagnosed with both ADHD and ASD are double-loaded with genetic risk for both disorders.

Manuel Mattheisen
Jakob Grove
Anders D. Børglum
Research26 Sept 2022
Nature Genetics

Volume: 54, P: 1470-1478
A concerted neuron–astrocyte program declines in ageing and schizophrenia

A synaptic neuron and astrocyte program (SNAP) varies among healthy humans, may shape interindividual differences in synapses and plasticity, and is undermined in schizophrenia and with advancing age.

Emi Ling
James Nemesh
Steven A. McCarroll
ResearchOpen Access06 Mar 2024
Nature

Volume: 627, P: 604-611
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Prostate cancer (PrCa) involves a large heritable genetic component. Here, the authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with potential application in clinical risk profiling.

Tokhir Dadaev
Edward J. Saunders
Zsofia Kote-Jarai
ResearchOpen Access11 Jun 2018
Nature Communications

Volume: 9, P: 1-19
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Mitochondrial damage activates the NLRP10 inflammasome

NLRP10 has been considered as an inflammasome inhibitor. Here the authors show that upon mitochondrial rupture, NLRP10 assembles a canonical inflammasome and is highly expressed in differentiated keratinocytes, possibly supporting skin homeostasis.

Tomasz Próchnicki
Matilde B. Vasconcelos
Eicke Latz
Research20 Mar 2023
Nature Immunology

Volume: 24, P: 595-603
Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome

Song and colleagues show that FDA-approved cough suppressant dextromethorphan could be used as an agonist of sigma non-opioid intracellular receptor 1 (SIGMAR1) to normalize the action potential in human cellular models and a mouse model of Timothy syndrome, a congenital disease with no available treatment. The researchers also show that dextromethorphan normalizes the action potential in human cellular models of two additional inherited cardiac arrhythmias: long QT syndrome types 1 and 2, which are caused by mutations in different genes.

LouJin Song
Ramsey Bekdash
Masayuki Yazawa
Research17 Feb 2022
Nature Cardiovascular Research

Volume: 1, P: 142-156
Application of machine learning algorithms to identify serological predictors of COVID-19 severity and outcomes

Dhakal, Yin, Escarra-Senmarti et al. investigate the associations of antibody biomarkers with recovery or death from COVID-19 using machine learning algorithms. They demonstrate the serological antibody measures, among COVID-19 patients, that predict intubation or death.

Santosh Dhakal
Anna Yin
Sabra L. Klein
ResearchOpen Access26 Nov 2024
Communications Medicine

Volume: 4, P: 1-15
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor

A recurrent gain-of-function mutation in ARAF causes lymphatic anomaly in two unrelated patients, and treating one of the patients with an FDA-approved MEK inhibitor resulted in a remarkable recovery, exemplifying the power of precision medicine.

Dong Li
Michael E. March
Hakon Hakonarson
Research01 Jul 2019
Nature Medicine

Volume: 25, P: 1116-1122
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States

Detailed clinical and virologic characteristics of the first 12 individuals with COVID-19 in the United States from the US Centers for Disease Control and Prevention.

Stephanie A. Kujawski
Karen K. Wong
Jing Zhang
Research23 Apr 2020
Nature Medicine

Volume: 26, P: 861-868
A subclass of tumor-inhibitory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptors

Leah N Klapper
Nora Vaisman
Michael Sela
Research01 May 1997
Oncogene

Volume: 14, P: 2099-2109
Publisher Correction: Shared heritability and functional enrichment across six solid cancers

Xia Jiang
Hilary K. Finucane
Sara Lindström
Amendments and CorrectionsOpen Access23 Sept 2019
Nature Communications

Volume: 10, P: 1-8
Development and external validation of nomograms in oropharyngeal cancer patients with known HPV-DNA status: a European Multicentre Study (OroGrams)

Christian Grønhøj
David H. Jensen
Christian von Buchwald
ResearchOpen Access24 May 2018
British Journal of Cancer

Volume: 118, P: 1672-1681
A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

Dong Li
Xiao Chang
Hakon Hakonarson
ResearchOpen Access19 Jun 2017
Scientific Reports

Volume: 7, P: 1-8
Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice

Nora M McCall
Lydia Kotecki
Kevin Wickman
Research29 Jul 2016
Neuropsychopharmacology

Volume: 42, P: 707-715
Neurocircuitry of Addiction

George F Koob
Nora D Volkow
Reviews26 Aug 2009
Neuropsychopharmacology

Volume: 35, P: 217-238
Evidence that Formulations of the Selective MAO-B Inhibitor, Selegiline, which Bypass First-Pass Metabolism, also Inhibit MAO-A in the Human Brain

Joanna S Fowler
Jean Logan
Lisa Muench
ResearchOpen Access24 Sept 2014
Neuropsychopharmacology

Volume: 40, P: 650-657
Differential predictors for alcohol use in adolescents as a function of familial risk

Mira Tschorn
Robert C. Lorenz
Amir Tahmasebi
ResearchOpen Access04 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-11
Erratum: A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

Dong Li
Xiao Chang
Hakon Hakonarson
Amendments and CorrectionsOpen Access21 Aug 2017
Scientific Reports

Volume: 7, P: 1-4
REPRESENT recommendations: improving inclusion and trust in cancer early detection research

Frederike Brockhoven
Maya Raphael
Ignacia Arteaga
ReviewsOpen Access09 Sept 2023
British Journal of Cancer

Volume: 129, P: 1195-1208
Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium

Nikhil K Khankari
Harvey J Murff
Wei Zheng
ResearchOpen Access04 Aug 2016
British Journal of Cancer

Volume: 115, P: 624-631

Search

Preparation and Mounting of Deliquescent Substances

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

KidneyGenAfrica, a pan-African partnership to deliver research and training excellence in genomics of kidney disease

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Kidney health outcomes of hypertensive disorders of pregnancy

Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Whole-genome sequencing reveals host factors underlying critical COVID-19

Associations of autozygosity with a broad range of human phenotypes

Shared heritability and functional enrichment across six solid cancers

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups

A concerted neuron–astrocyte program declines in ageing and schizophrenia

A second update on mapping the human genetic architecture of COVID-19

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Mitochondrial damage activates the NLRP10 inflammasome

Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome

Application of machine learning algorithms to identify serological predictors of COVID-19 severity and outcomes

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor

Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Clinical and virologic characteristics of the first 12 patients with coronavirus disease 2019 (COVID-19) in the United States

A subclass of tumor-inhibitory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptors

Publisher Correction: Shared heritability and functional enrichment across six solid cancers

Development and external validation of nomograms in oropharyngeal cancer patients with known HPV-DNA status: a European Multicentre Study (OroGrams)

A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice

Neurocircuitry of Addiction

Evidence that Formulations of the Selective MAO-B Inhibitor, Selegiline, which Bypass First-Pass Metabolism, also Inhibit MAO-A in the Human Brain

Differential predictors for alcohol use in adolescents as a function of familial risk

Erratum: A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

REPRESENT recommendations: improving inclusion and trust in cancer early detection research

Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium

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