Electron cryo-microscopy and image analysis of frozen-hydrated, two-dimensional crystals of gap junction membrane channels formed by recombinant α1 connexin (Cx43) reveal a ring of transmembrane α-helices that lines the aqueous pore and a second ring of α-helices in close contact with the membrane lipids.
- Vinzenz M. Unger
- Nalin M. Kumar
- Mark Yeager