The concept that the nervous system can adapt to gastrointestinal disorders is a new concept. In this Review the authors discuss neural plasticity in pancreatic diseases such as pancreatitis and cancer. Given the translational importance of neuropathic changes in pancreatic disorders the authors look at the available mouse models we have to study the phenomenon and highlight areas of research that still need investigation.
- Ihsan Ekin Demir
- Helmut Friess
- Güralp O. Ceyhan