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Identification of ephrin-A1–EphA2 signalling as a potential target for fracture prevention

Osteoporotic fractures are a major global health burden. Here the authors show, using proteome wide Mendelian randomization, that nine circulating proteins influence forearm fracture risk and identify a novel protective role for ephrin A1

Sofia Movérare-Skrtic
Maria Nethander
Claes Ohlsson
ResearchOpen Access21 Feb 2026
Nature Communications

P: 1-14

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Identification of ephrin-A1–EphA2 signalling as a potential target for fracture prevention

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