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Showing 1–4 of 4 results
Advanced filters: Author: Owain J. Bryant Clear advanced filters

  • In this work, authors show that Salmonella uses its SPI-1 injectisome to infect macrophages, triggering rapid translational upregulation of transcription factors, such as EGR1 which suppresses the inflammatory response, aiding the bacteria in establishing systemic infection

    • George Wood
    • Rebecca Johnson
    • Betty Y. W. Chung
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Here, the authors show that Salmonella activates the cytosolic PRR Nod-like Receptor CARD 4 (NLRC4), which limits adaptive T-cell responses in a NLRP3-dependent manner. Modification of Salmonella flagellin reduces NLRC4 activation and enhances protective immunity.

    • Panagiotis Tourlomousis
    • John A. Wright
    • Clare E. Bryant
    Research
    Nature Microbiology
    Volume: 5, P: 1588-1597

  • The bifunctional enzyme CoaBC catalyses the second and third step in the Coenzyme A (CoA) biosynthesis pathway and is of interest as a M. tuberculosis drug target. Here, the authors present the full-length crystal structure of Mycobacterium smegmatis CoaBC, which is regulated by CoA and CoA thioesters and forms a dodecamer and by performing a high-throughput screen they identify selective inhibitors of M. tuberculosis CoaB that bind to an allosteric site within CoaB.

    • Vitor Mendes
    • Simon R. Green
    • Tom L. Blundell
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12