RNA interference (RNAi) is a robust gene silencing mechanism that degrades mRNAs complementary to the antisense strands of double-stranded, short interfering RNAs. This Review describes the current status of research and clinical trials on RNAi-based therapeutics and addresses novel potential targets for the treatment of metabolic disease.
- Michael P. Czech
- Myriam Aouadi
- Gregory J. Tesz