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Merons are topological structures, but these have yet to be directly observed in ferroelectrics. Here, by epitaxially straining PbTiO₃ on a SmScO₃ substrate, electron microscopy and phase-field modelling allow the morphology and distribution of merons to be observed.

Developing autonomous self-healing materials for application under extreme conditions is challenging. Here, the authors design a highly stretchable elastomer by incorporation of H-bonds and disulphide methathesis, which shows efficient self-healing under extreme conditions.

Mutations in the TP53 gene are linked to cancer progression and drug resistance. Here, the authors show that mutant p53 inhibits stress granule formation, leading to increased apoptosis and enhanced sensitivity to the ER stress-inducing chemotherapy drug sorafenib in preclinical models of hepatocellular carcinoma.

Although trace compounds are known to inhibit crystal growth, the mechanisms by which they do so are unclear. Here, the authors use a microkinetic model to study the mechanisms of several inhibitors of calcite growth, finding that the processes are quite different for inorganic and organic inhibitors.

Initiating aripiprazole antipsychotic monotherapy versus olanzapine, quetiapine or risperidone might reduce cardiovascular event risk in severe mental illness. Here, the authors show patients initiating aripiprazole had similar 5-year risk as the comparators, but risk was higher in those continuing risperidone versus aripiprazole

Rice-infecting arboviruses adopt convergent strategies to overcome host defenses. Here, the authors show that viral proteins from distinct rice viruses boost OsTSN1 nuclease activity to suppress rice antiviral RNA decay immune response through promoting its phase separation and multimerization.

The ability to encapsulate living cells could lead to many applications. Here, the authors present a flexible method to graft DNA polymers onto bacteria, yeast and mammalian cells, polymerize them into DNA cocoons and use these to manipulate and select cells based on the encoded polymer sequences on DNA cocoons.

This study reveals that CYBDOM proteins promote drought tolerance by regenerating apoplastic ascorbic acid (AsA) and activating autophagy through interaction with RbohD, and link AsA redox, ROS and selective autophagy in plant stress responses

Sphingolipids in the trans-Golgi network have been implicated in polar trafficking. Here Wattelet-Boyer et al. show that hydroxylated C24- and C26-acyl-chain sphingolipids are enriched in trans-Golgi network subdomains that are critical for polar sorting of the PIN2 auxin carrier in plant cells.

Murphy et al. reveal a unifying pathogenetic mechanism according to which diverse mutations in the muscle-specific ribosomal protein RPL3L cause severe neonatal dilated cardiomyopathy, establishing a framework for interpreting the growing spectrum of RPL3L variants.

Using Xenopus egg extracts, the authors developed a mass spectrometry method (UBIMAX) to identify proteins ubiquitylated in response to defined DNA lesions. Highlighting UBIMAX’s versatility, they describe the ubiquitylation of the actin regulator Dbn1 in response to DNA double-strand breaks.

Here they show that mitochondria-localized NEK7 couples mitochondrial complex II subunit SDHB to maintain the homeostasis of electron transport in hepatocytes, thereby impeding the progression of liver fibrosis.

Mechanistic study of probiotic-synthesized PMP reveals its direct antibacterial activity and restoration of gut homeostasis during bacterial infection.

Lipolysis in adipose tissue releases fatty acids during fasting. Here, authors show that ApoL6, a lipid droplet-associated protein, is specifically expressed in adipocytes upon feeding to inhibit lipolysis by directly interacting with Perilipin 1 to competitively inhibit Perilipin 1-HSL interaction.

Tan et al. identify a regulatory network between colonic EECs and the gut microbiota that controls l-glutamic acid production, appetite and body weight in mice.

An optical method images nonlinear optical processes in waveguides with femtosecond and nanometre precision. The approach is used to achieve phase-matched second-harmonic generation in 3R-MoS₂ waveguides.

The origin and regulatory roles of isopentenyl phosphate (IP) in plant terpenoid metabolism remain unclear. Now, a study reports the enzymes for IP production and shows that these enzymes can be used to manipulate terpene production.

The barrier function of skin epidermis requires polarized secretion of lamellar bodies towards the body surface. Here, Rudd et al. identify Flower (FWE) as a novel regulator of lamellar body trafficking and a determinant of epidermal barrier function.

Protein/protein interaction (PPI) interfaces have emerged as drug targets to develop medications with less side effects. Here, Dvorak et al. show that small molecule targeting of PPIs in the brain is an approach for psychiatric drug discovery.

Smith and Bartel show that mRNA recruitment to stress granules imparts resistance to the integrated stress response translational shutdown.

A novel low-input, single-tube immunopeptidomics method uncovers widespread intratumor heterogeneity in MHC-I antigen presentation that is largely uncoupled from proteomic heterogeneity.

The contribution of genetic factors to the tumour immune microenvironment (TIME) remains to be investigated. Here, the authors suggest the role of TIME eQTLs for target genes involved in reversing immune suppressive features.

Here they demonstrate a therapeutic intervention elevating levels of CYP450-derived lipids to control the expansion of intermediate monocytes in tissue and peripheral blood, presenting a first in class therapeutic approach for treating chronic inflammatory disease.

The wheat genetic yield gap globally ranges from 30% to 70%, indicating current wheat yields are substantially below achievable genetic yield potentials. There is potential to close the existing genetic yield gap with crop genetic improvement and adaption.

Inhibitor-induced kinase degradation is a common event that positions supercharging of endogenous degradation circuits as an alternative to classical proximity-inducing degraders.

Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase, initiating the first step of the natural antiviral response in rice.

Repair of topoisomerase 1 (TOP1) DNA protein crosslinks (DPC) limits the efficacy of the TOP1 inhibitor irinotecan in cancer therapy. Here, the authors identify pevonedistat, NEDD8 inhibitor, as synergistic with irinotecan by blocking neddylation-activated ubiquitin/proteasomal degradation of TOP1-DPC.

An ultrasmall particle adjuvant therapy reprogrammes the tumour microenvironment of a resistant melanoma to a pro-inflammatory state, enhances antitumour immunity and synergizes with immune checkpoint inhibitors to prolong survival in murine models.

Previously, OLIG2-expressing stems cells have been identified as having a role in medulloblastoma recurrence. Here, the authors investigate the effects of targeting this OLIG2+ stem cell population in Sonic Hedgehog (SHH) medulloblastoma using CT-179, an OLIG2 inhibitor.

The Anaphase Promoting Complex adaptor protein Cdh1 tightly controls cell cycle progression to restrain tumorigenesis but the mechanism is not completely known. Here, the authors show that reciprocal inhibition between Cdh1 and the c-Src signaling pathway regulate breast cancer tumorigenesis.

Alternative splicing is dysregulated in hepatocellular carcinoma. Here, the authors investigate the role of the splice variant of Splicing Regulatory Glutamic Acid and Lysine Rich Protein 1 (SREK1) and its upstream regulator, Serine/arginine-rich splicing factor 10 (SRSF10) in sustaining the oncogenic signal.

Multiple cytokines in the proinflammatory IL-1 family share the co-receptor IL-1R3. Dinarello and colleagues show that a fully humanized antibody to IL-1R3 can effectively control inflammation and disease mediated not only by IL-1 but also by IL-33 and IL-36.

SOX2 is required for the maintenance of glioblastoma stem cells (GSCs). Here the authors identify that the RING family E3 ubiquitin ligase TRIM26 promotes SOX2 stability in a non-canonical ligase-independent manner and thus, increases the tumorigenicity of GSCs.

Empirical evidence that parasite-encoded tyrosine hydroxylases (TgTH), and hence parasite-produced dopamine, contribute to Toxoplasma gondii-associated behavioural alterations within the rat host.

Adoro and colleagues report the involvement of the IRE1α–XBP1 signaling axis in protecting hematopoietic stem and progenitor cells from proteomic stress and as a safeguard against leukemic transformation.

Control of ion diffusion is instrumental in understanding the behavior and structural transformations of transition metal oxides. Here, the authors use in-situ TEM to reveal the atomic-scale evolution of the topotactic phase transition in BM-SFO triggered by the migration of oxygen ions under an external stimulus.

This study elucidates molecular mechanisms of neuronal activity-dependent GLUT3 translocation to the plasma membrane and its role in supplying energy for learning and memory.

Ime4p is a yeast N6-methyladenosine (m6A) methyltransferase with an unknown role in meiosis. Rme1p is a repressor of meiosis. Here the authors show that Ime4p methylates RME1 3′ UTR to reduce its expression and enable meiosis, thus providing an example of an m6A site with a physiological role.

Treekitkarnmongkol, Katayama, Sankaran et al. identify RASH3D19 as a downstream target for KRAS signalling through miR-301a, which in turn leads to RAS activation and tumorigenesis. Targeting RASH3D19 inhibits growth of KRAS-mutant tumour cells in vivo.

MicroRNAs have been best characterized for their functions in the cytoplasm; however, there is growing evidence of a nuclear localized role. Here, the authors identify Sfpq as an Ago2-interacting protein that modulates miRNA activity in both the nucleus and cytoplasm.

The role of mosquito saliva proteins in viral infection remains incompletely understood. Here, the authors show that sialokinin facilitates viral dissemination while suppressing immune response and inflammation in chikungunya virus-infected mice.

Authors measure plasma proteins in a cohort of hospitalised patients presenting to the emergency department with suspected infection, revealing six discrete host response clusters that were driven by pathogen exposure and organ dysfunction, and had distinct clinical characteristics, hospital courses, and responses to treatment.