Nature Search

Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes

Append editing of ADP-ribosyl to thymine is used for precise modifications in bacteria and eukaryotes.

Darshana Gupta
Constantinos Patinios
Chase L. Beisel
ResearchOpen Access04 Sept 2025
Nature Biotechnology

P: 1-12
Effects of Hallucinogens on Locomotor and Investigatory Activity and Patterns: Influence of 5-HT_2A and 5-HT_2C Receptors

Kirsten Krebs-Thomson
Martin P Paulus
Mark A Geyer
Research01 May 1998
Neuropsychopharmacology

Volume: 18, P: 339-351
Long non-coding RNA levels can be modulated by 5-azacytidine in Schistosoma mansoni

Murilo S. Amaral
Lucas F. Maciel
Sergio Verjovski-Almeida
ResearchOpen Access09 Dec 2020
Scientific Reports

Volume: 10, P: 1-17
Printing photonic-based thermal barrier coatings onto metal alloy

Furlan’s team engineered the printing of Gd₂Zr₂O₇ photonic coatings on curved metal surfaces, achieving high reflectivity values that outperform state-of-the-art thermal barrier coatings while having remarkably low density and minimal thickness

Alberto Gomez-Gomez
Diego Ribas Gomes
Kaline P. Furlan
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-11
Fast-decaying plant litter enhances soil carbon in temperate forests but not through microbial physiological traits

Mineral-associated soil carbon buildup is poorly explained by microbial necromass production (a common hypothesis). During litter decomposition, these processes are decoupled by priming effects and alternate soil carbon formation pathways

Matthew E. Craig
Kevin M. Geyer
Richard P. Phillips
ResearchOpen Access09 Mar 2022
Nature Communications

Volume: 13, P: 1-10
Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma

The EWSR1::FLI1 fusion protein is the oncogenic driver of Ewing sarcoma (EwS). Here, the authors find that EWSR1::FLI1 plays a non-canonical role in mRNA decay via interactions with the CCR4-NOT deadenylation complex and the RNA-binding protein HuR. This role uncovers a new therapeutic vulnerability of EwS to HuR inhibition.

Bartimée Galvan
Loïc Ongena
Franck Dequiedt
ResearchOpen Access16 Jul 2025
Nature Communications

Volume: 16, P: 1-24
Modifying the insect cell N-glycosylation pathway with immediate early baculovirus expression vectors

Donald L. Jarvis
Eric E. Finn
Research01 Oct 1996
Nature Biotechnology

Volume: 14, P: 1288-1292
Differential Contributions of Dopamine D₁, D₂, and D₃ Receptors to MDMA-Induced Effects on Locomotor Behavior Patterns in Mice

Victoria B Risbrough
Virginia L Masten
Mark A Geyer
Research19 Jul 2006
Neuropsychopharmacology

Volume: 31, P: 2349-2358
Compromise-free scaling of qubit speed and coherence

Across qubit platforms, improving coherence often compromises operational speed. Here, the authors overcome this trade-off by electrically controlling a hole spin qubit in a Ge/Si core/shell nanowire, achieving triple manipulation speeds while quadrupling coherence times.

Miguel J. Carballido
Simon Svab
Dominik M. Zumbühl
ResearchOpen Access15 Aug 2025
Nature Communications

Volume: 16, P: 1-9
Non-Enzymatic Hydroxylation of Aromatic Compounds

J. H. GREEN
B. J. RALPH
P. J. SCHOFIELD
Research25 May 1963
Nature

Volume: 198, P: 754-756
Assessment of HMGA2 and PLAG1 rearrangements in breast adenomyoepitheliomas

Fresia Pareja
Felipe C. Geyer
Jorge S. Reis-Filho
ResearchOpen Access18 Jan 2019
npj Breast Cancer

Volume: 5, P: 1-5
The translational landscape of HIV-1 infected cells reveals key gene regulatory principles

A study by Kibe et al. of the translational landscape of HIV-1 reveals alternative translation events, including use of upstream and internal open reading frames, an RNA fold regulating gag-pol frameshifting and ribosome collisions, providing new targets for antivirals.

Anuja Kibe
Stefan Buck
Neva Caliskan
ResearchOpen Access15 Jan 2025
Nature Structural & Molecular Biology

Volume: 32, P: 841-852
Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk sarcomas

Sarcomas are a group of mesenchymal malignancies which are molecularly heterogeneous. Here, the authors develop an in vivo muscle electroporation system for gene delivery to generate distinct subtypes of orthotopic genetically engineered mouse models of sarcoma, as well as syngeneic allograft models with scalability for preclinical assessment of therapeutics.

Roland Imle
Daniel Blösel
Ana Banito
ResearchOpen Access16 Jun 2025
Nature Communications

Volume: 16, P: 1-20
Pharmacological Stimulation of Locus Coeruleus Reveals a New Antipsychotic-Responsive Pathway for Deficient Sensorimotor Gating

Karen M Alsene
Vaishali P Bakshi
Research20 Apr 2011
Neuropsychopharmacology

Volume: 36, P: 1656-1667
M100907, a Serotonin 5-HT_2A Receptor Antagonist and Putative Antipsychotic, Blocks Dizocilpine-Induced Prepulse Inhibition Deficits in Sprague–Dawley and Wistar Rats

Geoffrey B Varty
Vaishali P Bakshi
Geoffrey B Varty
Research01 Apr 1999
Neuropsychopharmacology

Volume: 20, P: 311-321
Correlation of Behavioural Differences in Three Strains of Mice with Differences in Brain Amines

E. KEMPF
J. GREILSAMER
P. MANDEL
Research15 Feb 1974
Nature

Volume: 247, P: 483-485
Hydroplastic polymers as eco-friendly hydrosetting plastics

Eco-friendly processing of plastics could leverage the advantages of plastics while maximizing their environmental sustainability. Here the authors show a cellulose cinnamate polymer that could be repeatedly programmed into various 2D or 3D stable shapes through a sustainable hydrosetting process.

Jiaxiu Wang
Lukas Emmerich
Kai Zhang
Research08 Jul 2021
Nature Sustainability

Volume: 4, P: 877-883
BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect

Andrew R Hallahan
Joel I Pritchard
James M Olson
Research20 Jul 2003
Nature Medicine

Volume: 9, P: 1033-1038
Proteomic analysis of the urothelial cancer landscape

Urothelial cancer is a challenging disease and an emerging field for targeted therapies. Here, the authors optimize clinical proteomics to provide proteome-level data on tumor specificity and identify robust prognostic subtypes with predictive information for repurposed drug candidates.

Franz F. Dressler
Falk Diedrichs
Ákos Végvári
ResearchOpen Access27 May 2024
Nature Communications

Volume: 15, P: 1-19
Reversal of Startle Gating Deficits in Transgenic Mice Overexpressing Corticotropin-Releasing Factor by Antipsychotic Drugs

Anneloes Dirks
Lucianne Groenink
Berend Olivier
Research03 Jun 2003
Neuropsychopharmacology

Volume: 28, P: 1790-1798
Sensorimotor Gating Deficits in Transgenic Mice Expressing a Constitutively Active Form of G_sα

Thomas J Gould
Scott P Bizily
Ted Abel
Research10 Nov 2003
Neuropsychopharmacology

Volume: 29, P: 494-501
Genomic and phenotypic stability of fusion-driven pediatric sarcoma cell lines

It has been reported that human cancer cell lines present significant diversity across laboratories and become heterogeneous during long-term culture. Here, the authors show that oligo-mutated pediatric sarcoma cell lines are genetically and phenotypically more stable than the highly mutated adult carcinoma cell lines.

Merve Kasan
Florian H. Geyer
Florencia Cidre-Aranaz
ResearchOpen Access03 Jan 2025
Nature Communications

Volume: 16, P: 1-9
DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon

DNA methyltransferase 3 A (DNMT3A) is involved in DNA methylation, and genetic variants in the DNMT3 locus have been associated with inflammatory bowel disease. Here the authors report that DNMT3A controls intestinal epithelial barrier function and restoration of the gut barrier function after intestinal epithelial perturbation.

Antonella Fazio
Dora Bordoni
Philip Rosenstiel
ResearchOpen Access21 Oct 2022
Nature Communications

Volume: 13, P: 1-19
Targeted multicolor in vivo imaging over 1,000 nm enabled by nonamethine cyanines

Rational design was used to develop a suite of red-shifted, bioconjugatable heptamethine cyanine dyes for multiplexed in vivo imaging in the shortwave-infrared/near-infrared-II region.

Venu G. Bandi
Michael P. Luciano
Martin J. Schnermann
Research28 Feb 2022
Nature Methods

Volume: 19, P: 353-358
Non-Enzymatic Hydroxylation of Aromatic Compounds

J. H. GREEN
B. J. RALPH
P. J. SCHOFIELD
Research29 Sept 1962
Nature

Volume: 195, P: 1309-1311
Conversion of methane into higher hydrocarbons on platinum

M. Belgued
P. Pareja
H. Amariglio
Research29 Aug 1991
Nature

Volume: 352, P: 789-790
Structural basis of Cdk7 activation by dual T-loop phosphorylation

Cyclin-dependent kinase 7 (Cdk7) is required in cell-cycle and transcriptional regulation. It is regulated by two phosphorylations in the activation segment. Here, the authors report a structure of the human Cdk7/Cyclin H/Mat1 complex containing both phosphorylations, with further insights into the regulatory mechanisms.

Robert Düster
Kanchan Anand
Matthias Geyer
ResearchOpen Access03 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis

Fibroblast-like synoviocytes are important mediators of joint pathology in rheumatoid arthritis (RA). Here the authors show that Lasp1 is epigenetically regulated and highly expressed by these cells in RA and its deletion can limit joint pathology in a mouse model of inflammatory arthritis.

Denise Beckmann
Anja Römer-Hillmann
Adelheid Korb-Pap
ResearchOpen Access15 Jun 2021
Nature Communications

Volume: 12, P: 1-17
Constitutive Activation of Gαs within Forebrain Neurons Causes Deficits in Sensorimotor Gating Because of PKA-Dependent Decreases in cAMP

Michele P Kelly
Carolina Isiegas
Ted Abel
Research31 May 2006
Neuropsychopharmacology

Volume: 32, P: 577-588
Two different areas within the primary motor cortex of man

Stefan Geyer
Anders Ledberg
Per E. Roland
Research29 Aug 1996
Nature

Volume: 382, P: 805-807
Selumetinib in adults with NF1 and inoperable plexiform neurofibroma: a phase 2 trial

In a phase 2 trial of adults with neurofibromatosis type 1 and inoperable/growing plexiform neurofibromas, treatment with the MEK inhibitor selumetinib resulted in an objective response rate of 63.6% and improvement in other patient outcomes, with additional biopsy-based data providing further information on drug activity.

Andrea M. Gross
Geraldine O’Sullivan Coyne
Brigitte C. Widemann
Research06 Jan 2025
Nature Medicine

Volume: 31, P: 105-115
Structure of antiviral drug bulevirtide bound to hepatitis B and D virus receptor protein NTCP

Hepatitis B and D viruses require docking to the NTCP receptor protein for cell entry, an interaction that can be blocked by the drug bulevirtide. Here the authors use cryo-EM to reveal the structural basis of bulevirtide activity.

Hongtao Liu
Dariusz Zakrzewicz
Kaspar P. Locher
ResearchOpen Access20 Mar 2024
Nature Communications

Volume: 15, P: 1-13
Prevalence of glaucoma in patients with obstructive sleep apnoea—a cross-sectional case-series

R E Bendel
J Kaplan
S-C Lin
Research04 May 2007
Eye

Volume: 22, P: 1105-1109
21-Gene assay as predictor of chemotherapy benefit in HER2-negative breast cancer

Charles E. Geyer Jr.
Gong Tang
Norman Wolmark
ResearchOpen Access14 Nov 2018
npj Breast Cancer

Volume: 4, P: 1-6
Plastic futures and their CO₂ emissions

Three alternative CO₂ emission-mitigation pathways were analysed for the global plastics sector, covering their production to waste management. A circular bioeconomy strategy could achieve negative emissions in the long term, while at the same time allowing landfilling to be phased out and reducing resource consumption.

Paul Stegmann
Vassilis Daioglou
Martin Junginger
Research07 Dec 2022
Nature

Volume: 612, P: 272-276
The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP96 and class I homeoprotein HOXA9

Julian Borrow
Amanda M. Shearman
David E. Housman
Research01 Feb 1996
Nature Genetics

Volume: 12, P: 159-167
Systematic evaluation of factors influencing ChIP-seq fidelity

The authors analyze how sequencing depth, choice of control sample, paired-end versus single-end reads and the selection of peak-calling algorithm influence the interpretation of chromatin immunoprecipitation–sequencing (ChIP-seq) experiments.

Yiwen Chen
Nicolas Negre
X Shirley Liu
Research22 Apr 2012
Nature Methods

Volume: 9, P: 609-614
A xandarellid artiopodan from Morocco – a middle Cambrian link between soft-bodied euarthropod communities in North Africa and South China

Javier Ortega-Hernández
Abdelfattah Azizi
Khadija El Hariri
ResearchOpen Access17 Feb 2017
Scientific Reports

Volume: 7, P: 1-16
Ventral Striatal Noradrenergic Mechanisms Contribute to Sensorimotor Gating Deficits Induced by Amphetamine

Karen M Alsene
Katie Fallace
Vaishali P Bakshi
Research04 Aug 2010
Neuropsychopharmacology

Volume: 35, P: 2346-2356
Structure and function of the multifunctional DNA-repair enzyme exonuclease III

Clifford D. Mol
Che-Fu Kuo
John A. Tainer
Research23 Mar 1995
Nature

Volume: 374, P: 381-386
The histogenesis of mammary tumours induced in the rat by chemical carcinogens

P J Middleton
Research01 Dec 1965
British Journal of Cancer

Volume: 19, P: 830-839
Convergence and Divergence in the Neurochemical Regulation of Prepulse Inhibition of Startle and N40 Suppression in Rats

Neal R Swerdlow
Mark A Geyer
Pamela P Auerbach
Research10 Aug 2005
Neuropsychopharmacology

Volume: 31, P: 506-515
Disruption of Prepulse Inhibition after Stimulation of Central but not Peripheral α-1 Adrenergic Receptors

Karen M Alsene
Barbara S Carasso
Vaishali P Bakshi
Research11 Jan 2006
Neuropsychopharmacology

Volume: 31, P: 2150-2161
Antagonism by Prostaglandins of the Responses of Various Smooth Muscle Preparations to Sympathomimetics

P. CATHERINE CLEGG
Research12 Mar 1966
Nature

Volume: 209, P: 1137-1139
Profiling the human intestinal environment under physiological conditions

Variations in microbial composition, phage induction, antimicrobial resistance genes and bile acid profiles are identified by using an ingestible device for site-specific sampling along the intestines.

Dari Shalon
Rebecca Neal Culver
Kerwyn Casey Huang
ResearchOpen Access10 May 2023
Nature

Volume: 617, P: 581-591
Genetic determinants of micronucleus formation in vivo

Genetic screening identifies a rich catalogue of regulators of micronucleus formation.

D. J. Adams
B. Barlas
G. Balmus
ResearchOpen Access14 Feb 2024
Nature

Volume: 627, P: 130-136
The structure and substrate specificity of human Cdk12/Cyclin K

Cyclin-dependent kinase 12 (Cdk12) phosphorylates the C-terminal domain (CTD) of RNA polymerase II to regulate transcription. Here, the authors solve the crystal structure of the Cdk12 kinase domain and show that Cdk12 has its highest activity on a CTD substrate that carries a serine 7 phosphorylation.

Christian A. Bösken
Lucas Farnung
Matthias Geyer
ResearchOpen Access24 Mar 2014
Nature Communications

Volume: 5, P: 1-14
Amphetamine Effects on Prepulse Inhibition Across-Species: Replication and Parametric Extension

Neal R Swerdlow
Nora Stephany
Pamela P Auerbach
Research13 Sept 2002
Neuropsychopharmacology

Volume: 28, P: 640-650
Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas

Adenomyoepithelioma is a rare tumor of the breast with an unknown genetic basis. Here the authors perform a genomic analysis of adenomyoepitheliomas revealing that their repertoire of somatic mutations vary according to the estrogen receptor (ER) status, and that ER-negative tumors harbor recurrent mutations in HRAS and PI3K pathway genes.

Felipe C. Geyer
Anqi Li
Jorge S. Reis-Filho
ResearchOpen Access08 May 2018
Nature Communications

Volume: 9, P: 1-16
Pregnancy lifestyle interventions and child health: lessons learned from the GeliS trial

Gregory P. Goldstein
Elizabeth Yen
Jonathan M. Davis
Comments & Opinion27 Mar 2025
Pediatric Research

Volume: 98, P: 363-364

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