Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Pablo Laborda Clear advanced filters

  • Mutations in mexZ, encoding a negative regulator of efflux pump genes, are frequently acquired by Pseudomonas aeruginosa during early lung infection, but do not confer high antibiotic resistance as measured in lab tests. Here, Laborda et al. show that mexZ mutations affect quorum sensing pathways, thus promoting tissue invasiveness and protecting bacteria from the action of antibiotics within tissues.

    • Pablo Laborda
    • Signe Lolle
    • Helle Krogh Johansen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • In this work, authors show that macrolides are effective against Pseudomonas aeruginosa infections despite intrinsic resistance. Prolonged use leads to ribosomal mutations causing resistance but also reduces virulence, aiding in long-term persistent infections.

    • Lise Goltermann
    • Pablo Laborda
    • Ruggero La Rosa
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • In this Review, Martínez, Hernando-Amado and colleagues explore how eco-evolutionary-based approaches can aid in the design of successful antibiotic therapies, including the exploitation of evolutionary trade-offs, targeting bacterial metabolism and studying the ancestral functions of antibiotic resistance determinants.

    • Fernando Sanz-García
    • Teresa Gil-Gil
    • Sara Hernando-Amado
    Reviews
    Nature Reviews Microbiology
    Volume: 21, P: 671-685