Nature Search

Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel

Eric Lingueglia
Guy Champigny
Pascal Barbry
Research14 Dec 1995
Nature

Volume: 378, P: 730-733
An integrated cell atlas of the lung in health and disease

A single-cell atlas of the human lungs, integrating data from 2.4 million cells from 486 individuals and including samples from healthy and diseased lungs, provides a roadmap for the generation of organ-scale cell atlases.

Lisa Sikkema
Ciro Ramírez-Suástegui
Fabian J. Theis
ResearchOpen Access08 Jun 2023
Nature Medicine

Volume: 29, P: 1563-1577
Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

Wilfried Dalemans
Pascal Barbry
Michel Lazdunski
Research26 Dec 1991
Nature

Volume: 354, P: 526-528
Aging affects reprogramming of pulmonary capillary endothelial cells after lung injury in male mice

Here the authors report single-cell and spatial transcriptomics of young and aged male fibrotic mouse lungs. Age-related alterations in capillary sub-populations are associated with a proangiogenic phenotype linked to regeneration of the alveolar niche.

Marin Truchi
Marine Gautier-Isola
Bernard Mari
ResearchOpen Access06 Aug 2025
Nature Communications

Volume: 16, P: 1-21
A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

Paul Hofman and colleagues show that a synonymous variant in IRGM, previously associated with risk of Crohn's disease, alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy. These findings implicate this synonymous polymorphism as a likely causal variant underlying the association of IRGM with Crohn's disease.

Patrick Brest
Pierre Lapaquette
Paul Hofman
Research30 Jan 2011
Nature Genetics

Volume: 43, P: 242-245
Erratum: Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

Brice Marcet
Benoît Chevalier
Pascal Barbry
Amendments and Corrections03 Oct 2011
Nature Cell Biology

Volume: 13, P: 1280
Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

The mechanisms governing the biosynthesis of multiple motile cilia in vertebrates remain largely elusive. miR-449 accumulates specifically in multiciliated cells of Xenopus skin and human lung to promote multicilia formation through modulation of Notch signalling.

Brice Marcet
Benoît Chevalier
Pascal Barbry
Research22 May 2011
Nature Cell Biology

Volume: 13, P: 693-699
An ABC of ciliogenesis

ABCC4 is a member of the ATP-binding cassette transporter family known to transport prostaglandin E2 and other molecules across cellular membranes. A mutation in ABCC4 is now shown to cause defects in ciliogenesis, revealing a role for prostaglandin signalling in regulating cilia dynamics.

Pascal Barbry
Laure-Emmanuelle Zaragosi
News & Views01 Sept 2014
Nature Cell Biology

Volume: 16, P: 826-827
GLS2 links glutamine metabolism and atherosclerosis by remodeling artery walls

Murcy et al. show that increasing the plasma glutamine-to-glutamate ratio in atherosclerosis can distally reprogram transcriptional and post-transcriptional remodeling of the aorta by GLS2-dependent hepatic glutaminolysis.

Florent Murcy
Coraline Borowczyk
Laurent Yvan-Charvet
Research19 Nov 2024
Nature Cardiovascular Research

Volume: 3, P: 1454-1467
High throughput error corrected Nanopore single cell transcriptome sequencing

Droplet-based high throughput single cell sequencing techniques can often lose information on transcript splicing and heterogenity. Here the authors introduce ScNaUmi-seq, which uses Oxford Nanopore sequencing and barcoding to generate high accuracy full length sequences.

Kevin Lebrigand
Virginie Magnone
Rainer Waldmann
ResearchOpen Access12 Aug 2020
Nature Communications

Volume: 11, P: 1-8
miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways

MicroRNAs of the miR-34/449 family initiate formation of multiciliated cells through the suppression of cell cycle genes and Notch. Here the authors show that miR-34/449 also regulate the assembly of an apical actin network necessary for basal body anchoring by regulating the expression of R-Ras.

Benoît Chevalier
Anna Adamiok
Brice Marcet
ResearchOpen Access18 Sept 2015
Nature Communications

Volume: 6, P: 1-14
CDC20B is required for deuterosome-mediated centriole production in multiciliated cells

In vertebrate multiciliated cells, most centrioles are synthesized and released by poorly characterized structures called deuterosomes. Here, the authors report that the previously-uncharacterized Cdc20b in mouse and Xenopus associates with deuterosomes and contributes to centriole release.

Diego R. Revinski
Laure-Emmanuelle Zaragosi
Pascal Barbry
ResearchOpen Access07 Nov 2018
Nature Communications

Volume: 9, P: 1-15
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

An integrated analysis of over 100 single-cell and single-nucleus transcriptomics studies illustrates severe acute respiratory syndrome coronavirus 2 viral entry gene coexpression patterns across different human tissues, and shows association of age, smoking status and sex with viral entry gene expression in respiratory cell populations.

Christoph Muus
Malte D. Luecken
Xiaohui Zhang
Research02 Mar 2021
Nature Medicine

Volume: 27, P: 546-559
COVID-19 patients age, comorbidity profiles and clinical presentation related to the SARS-CoV-2 UK-variant spread in the Southeast of France

Johan Courjon
Julie Contenti
Michel Carles
ResearchOpen Access16 Sept 2021
Scientific Reports

Volume: 11, P: 1-6
Brown adipose tissue monocytes support tissue expansion

Adipose tissue is composed of a number of adipocytes and a number of other cells including immune cells. Here the authors use single-cell sequencing of murine brown adipose tissue immune cells and describe multiple macrophage and monocyte subsets and show that monocytes contribute to brown adipose tissue expansion.

Alexandre Gallerand
Marion I. Stunault
Stoyan Ivanov
ResearchOpen Access06 Sept 2021
Nature Communications

Volume: 12, P: 1-13
Genome evolution across 1,011 Saccharomyces cerevisiae isolates

Whole-genome sequencing of 1,011 natural isolates of the yeast Saccharomyces cerevisiae reveals its evolutionary history, including a single out-of-China origin and multiple domestication events, and provides a framework for genotype–phenotype studies in this model organism.

Jackson Peter
Matteo De Chiara
Joseph Schacherer
ResearchOpen Access11 Apr 2018
Nature

Volume: 556, P: 339-344
miR-7a regulation of Pax6 controls spatial origin of forebrain dopaminergic neurons

The authors show that the microRNA miR-7a fine-tunes the expression of the transcription factor Pax6, generating a dorsal-ventral gradient that controls differentiation of olfactory bulb precursors into dopaminergic neurons.

Antoine de Chevigny
Nathalie Coré
Harold Cremer
Research24 Jun 2012
Nature Neuroscience

Volume: 15, P: 1120-1126
Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq

MicroRNAs have been best characterized for their functions in the cytoplasm; however, there is growing evidence of a nuclear localized role. Here, the authors identify Sfpq as an Ago2-interacting protein that modulates miRNA activity in both the nucleus and cytoplasm.

Silvia Bottini
Nedra Hamouda-Tekaya
Michele Trabucchi
ResearchOpen Access30 Oct 2017
Nature Communications

Volume: 8, P: 1-16
Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 and poor outcomes. Here the authors compare the transcriptomes of single cells isolated from healthy and CLD lungs to identify molecular characteristics of lung cells that may account for worse COVID-19 outcomes in these patients.

Linh T. Bui
Nichelle I. Winters
Laure Emmanuelle Zaragosi
ResearchOpen Access14 Jul 2021
Nature Communications

Volume: 12, P: 1-13
Longevity strategies in response to light in the reef coral Stylophora pistillata

Alexandre Ottaviani
Rita Eid
Denis Allemand
ResearchOpen Access17 Nov 2020
Scientific Reports

Volume: 10, P: 1-10
Correction: Corrigendum: miR-200 family controls late steps of postnatal forebrain neurogenesis via Zeb2 inhibition

Christophe Beclin
Philipp Follert
Harold Cremer
Amendments and CorrectionsOpen Access21 Dec 2016
Scientific Reports

Volume: 6, P: 1
miR-200 family controls late steps of postnatal forebrain neurogenesis via Zeb2 inhibition

Christophe Beclin
Philipp Follert
Harold Cremer
ResearchOpen Access21 Oct 2016
Scientific Reports

Volume: 6, P: 1-12
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

An analysis of single-cell transcriptomics datasets from different tissues shows that ACE2 and TMPRSS2 are co-expressed in respiratory, corneal and intestinal epithelial cell populations, and that respiratory expression of ACE2 is associated with genes involved in innate immunity.

Waradon Sungnak
Ni Huang
Francisco Figueiredo
Research23 Apr 2020
Nature Medicine

Volume: 26, P: 681-687
Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease

Charlotte Pandiani
Thomas Strub
Corine Bertolotto
Research18 Jan 2021
Cell Death & Differentiation

Volume: 28, P: 1990-2000
Gene expression profiling in human gastric mucosa infected with Helicobacter pylori

Véronique J Hofman
Chimène Moreilhon
Paul M Hofman
Research20 Jul 2007
Modern Pathology

Volume: 20, P: 974-989
The nuclear hypoxia-regulated NLUCAT1 long non-coding RNA contributes to an aggressive phenotype in lung adenocarcinoma through regulation of oxidative stress

Laura Moreno Leon
Marine Gautier
Roger Rezzonico
Research15 Aug 2019
Oncogene

Volume: 38, P: 7146-7165
Correction: The nuclear hypoxia-regulated NLUCAT1 long non-coding RNA contributes to an aggressive phenotype in lung adenocarcinoma through regulation of oxidative stress

Laura Moreno Leon
Marine Gautier
Roger Rezzonico
Amendments and Corrections08 Mar 2021
Oncogene

Volume: 40, P: 2621
A roadmap for the Human Developmental Cell Atlas

This Perspective outlines the Human Developmental Cell Atlas initiative, which uses state-of-the-art technologies to map and model human development across gestation, and discusses the early milestones that have been achieved.

Muzlifah Haniffa
Deanne Taylor
Matthias Zilbauer
Reviews08 Sept 2021
Nature

Volume: 597, P: 196-205
The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats

Thomas Simonet
Laure-Emmanuelle Zaragosi
Eric Gilson
Research22 Mar 2011
Cell Research

Volume: 21, P: 1028-1038
Gene expression profiling of normal human pulmonary fibroblasts following coculture with non-small-cell lung cancer cells reveals alterations related to matrix degradation, angiogenesis, cell growth and survival

Olivia Fromigué
Krystel Louis
Bernard Mari
Research20 Nov 2003
Oncogene

Volume: 22, P: 8487-8497

Search

Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel

An integrated cell atlas of the lung in health and disease

Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation

Aging affects reprogramming of pulmonary capillary endothelial cells after lung injury in male mice

A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease

Erratum: Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

An ABC of ciliogenesis

GLS2 links glutamine metabolism and atherosclerosis by remodeling artery walls

High throughput error corrected Nanopore single cell transcriptome sequencing

miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways

CDC20B is required for deuterosome-mediated centriole production in multiciliated cells

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

COVID-19 patients age, comorbidity profiles and clinical presentation related to the SARS-CoV-2 UK-variant spread in the Southeast of France

Brown adipose tissue monocytes support tissue expansion

Genome evolution across 1,011 Saccharomyces cerevisiae isolates

miR-7a regulation of Pax6 controls spatial origin of forebrain dopaminergic neurons

Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

Longevity strategies in response to light in the reef coral Stylophora pistillata

Correction: Corrigendum: miR-200 family controls late steps of postnatal forebrain neurogenesis via Zeb2 inhibition

miR-200 family controls late steps of postnatal forebrain neurogenesis via Zeb2 inhibition

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease

Gene expression profiling in human gastric mucosa infected with Helicobacter pylori

The nuclear hypoxia-regulated NLUCAT1 long non-coding RNA contributes to an aggressive phenotype in lung adenocarcinoma through regulation of oxidative stress

Correction: The nuclear hypoxia-regulated NLUCAT1 long non-coding RNA contributes to an aggressive phenotype in lung adenocarcinoma through regulation of oxidative stress

A roadmap for the Human Developmental Cell Atlas

The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats

Gene expression profiling of normal human pulmonary fibroblasts following coculture with non-small-cell lung cancer cells reveals alterations related to matrix degradation, angiogenesis, cell growth and survival

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