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Showing 51–100 of 174 results

Advanced filters: Author: Pascal Meier Clear advanced filters

Erratum: PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

Fara Brasó-Maristany
Simone Filosto
Andrew N Tutt
Amendments and Corrections07 Apr 2017
Nature Medicine

Volume: 23, P: 526
Erratum: PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

Fara Brasó-Maristany
Simone Filosto
Andrew N Tutt
Amendments and Corrections06 Jun 2017
Nature Medicine

Volume: 23, P: 788
Laparoscopic partial nephrectomy: an evolving standard

This Viewpoint documents developments in the treatment of small renal masses, focusing on the current status of laparoscopic partial nephrectomy. The authors argue that, with careful patient selection, meticulous technique and considerable laparoscopic experience, laparoscopic partial nephrectomy can be performed reproducibly and reliably with equivalent oncologic and renal functional outcomes to open surgery.

Monish Aron
Georges-Pascal Haber
Inderbir S Gill
Reviews01 Mar 2007
Nature Clinical Practice Urology

Volume: 4, P: 116-117
CTCF loss has limited effects on global genome architecture in Drosophila despite critical regulatory functions

Although the Drosophila genome has widespread contact domains and CTCF, it remains unclear whether CTCF-dependent domains exist in flies. Here, the authors ablate CTCF in Drosophila and find that CTCF is required to form a small fraction of all domain boundaries, suggesting differences in the role of CTCF for genome folding in flies and vertebrates.

Anjali Kaushal
Giriram Mohana
Maria Cristina Gambetta
ResearchOpen Access12 Feb 2021
Nature Communications

Volume: 12, P: 1-16
Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance

Necroptosis is a form of cell death characterized by membrane rupture via MLKL oligomerization, although mechanistic details remain unclear. Here, the authors show that MLKL ubiquitylation of K219 facilitates high-order membrane assembly and subsequent rupture, promoting cytotoxicity.

Laura Ramos Garcia
Tencho Tenev
Pascal Meier
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-18
EFA6B regulates a stop signal for collective invasion in breast cancer

Reduced expression of EFA6B is found in highly metastatic breast cancer subtypes. Here, the authors report that loss of EFA6B promotes collective invasion through activation of the epithelial-to-mesenchymal transition program and CDC42-dependent signalling pathways in breast cancer.

Racha Fayad
Monserrat Vázquez Rojas
Frédéric Luton
ResearchOpen Access13 Apr 2021
Nature Communications

Volume: 12, P: 1-17
Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease

Charlotte Pandiani
Thomas Strub
Corine Bertolotto
Research18 Jan 2021
Cell Death & Differentiation

Volume: 28, P: 1990-2000
Assessment of body composition in the advanced stage of castration-resistant prostate cancer: special focus on sarcopenia

Judith Stangl-Kremser
Rodrigo Suarez‐Ibarrola
Pascal Baltzer
Research19 Nov 2019
Prostate Cancer and Prostatic Diseases

Volume: 23, P: 309-315
Ecology of vertical tumor transmission in the freshwater cnidarian Hydra oligactis

N. Stepanskyy
M. Pascal
A. M. Dujon
ResearchOpen Access18 Feb 2025
Scientific Reports

Volume: 15, P: 1-16
Excess calorie intake early in life increases susceptibility to colitis in adulthood

Al Nabhani et al. show how excessive caloric intake during the postnatal period increases the risk of developing intestinal bowel disease during adulthood, owing to increased intestinal permeability, cytokines and hydrogen sulfide production by the microbiota.

Ziad Al Nabhani
Sophie Dulauroy
Gérard Eberl
Research04 Nov 2019
Nature Metabolism

Volume: 1, P: 1101-1109
Integrative Network-based Analysis of Magnetic Resonance Spectroscopy and Genome Wide Expression in Glioblastoma multiforme

Dieter Henrik Heiland
Irina Mader
Astrid Weyerbrock
ResearchOpen Access28 Jun 2016
Scientific Reports

Volume: 6, P: 1-9
Structure and mechanism of the K⁺/H⁺ exchanger KefC

Intracellular potassium (K+) homeostasis is achieved by activity of both ion channels and transporters. Here, the authors report structures of E. coli glutathione (GSH)-gated K+ efflux transporter KefC with bound K+ and conclude that the ion-binding site is adapted for binding a dehydrated ion.

Ashutosh Gulati
Surabhi Kokane
David Drew
ResearchOpen Access04 Jun 2024
Nature Communications

Volume: 15, P: 1-14
PREDICT validity for prognosis of breast cancer patients with pathogenic BRCA1/2 variants

Taru A. Muranen
Anna Morra
Heli Nevanlinna
ResearchOpen Access12 May 2023
npj Breast Cancer

Volume: 9, P: 1-15
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

Identification in Rwanda of mutations in Plasmodium falciparum capable of conferring in vitro resistance to artemisinin, an essential medicine for the treatment of malaria, underscore the crucial need for surveillance in Africa to safeguard efficacy of life-saving therapies.

Aline Uwimana
Eric Legrand
Didier Menard
ResearchOpen Access03 Aug 2020
Nature Medicine

Volume: 26, P: 1602-1608
Crystal structure of the Na⁺/H⁺ antiporter NhaA at active pH reveals the mechanistic basis for pH sensing

By determining the crystal structure of the Na + /H + antiporter NhaA at active pH, the authors show how substrate accessibility to the ion-binding site can be controlled by pH sensitive switch located on the cytoplasmic surface.

Iven Winkelmann
Povilas Uzdavinys
David Drew
ResearchOpen Access26 Oct 2022
Nature Communications

Volume: 13, P: 1-12
Regulatory T cells define affinity thresholds for CD8⁺ T cell tumor infiltration

Mona O. Mohsen
Romano Josi
Martin F. Bachmann
ResearchOpen Access13 Jun 2025
npj Vaccines

Volume: 10, P: 1-15
Retention rate of subcutaneous TNF inhibitors in axial spondyloarthritis in a multicentre study from the RIC-FRANCE network

Guillaume Larid
Guy Baudens
Elisabeth Gervais
ResearchOpen Access16 Jan 2024
Scientific Reports

Volume: 14, P: 1-12
Two-screw osteosynthesis is biomechanically superior to single-screw osteosynthesis for type II odontoid fractures

Paul Jonathan Roch
Elisa Salge
Lukas Weiser
ResearchOpen Access15 Aug 2024
Scientific Reports

Volume: 14, P: 1-9
Microbial network disturbances in relapsing refractory Crohn’s disease

A disturbed microbial network characterizes relapsing refractory Crohn’s disease and antedates disease recurrence after surgical removal of the active disease segment.

Bahtiyar Yilmaz
Pascal Juillerat
Andrew J. Macpherson
Research21 Jan 2019
Nature Medicine

Volume: 25, P: 323-336
SUMO-mediated regulation of NLRP3 modulates inflammasome activity

The NLRP3 inflammasome is an important component of inflammatory responses, but how it is negatively regulated is still unclear. Here the authors show that post-translational modification of NLRP3 by sumoylation suppresses inflammasome activity, and that desumoylation of NLRP3 by the SENP6 and SENP7 proteases promotes NLRP3 activation.

Rachael Barry
Sidonie Wicky John
Pascal Meier
ResearchOpen Access01 Aug 2018
Nature Communications

Volume: 9, P: 1-14
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

Genome-wide association studies have uncovered several loci associated with diabetes risk. Here, the authors reanalyse public type 2 diabetes GWAS data to fine map 50 known loci and identify seven new ones, including one near ATGR2 on the X-chromosome that doubles the risk of diabetes in men.

Sílvia Bonàs-Guarch
Marta Guindo-Martínez
David Torrents
ResearchOpen Access22 Jan 2018
Nature Communications

Volume: 9, P: 1-14
The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors

The immune system tailors its responses according to the level of threat. Lemaitre and colleagues identify a novel version of the peptidoglycan receptor PGRP-LC and demonstrate that it tunes immune responses to live (threatening) or dead (harmless) bacteria.

Claudine Neyen
Christopher Runchel
Bruno Lemaitre
Research22 Aug 2016
Nature Immunology

Volume: 17, P: 1150-1158
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility

Genome-wide association analyses identify new susceptibility loci for Brugada syndrome. Functional studies implicate microtubule-related trafficking effects on sodium channel expression as an underlying molecular mechanism.

Julien Barc
Rafik Tadros
Connie R. Bezzina
Research24 Feb 2022
Nature Genetics

Volume: 54, P: 232-239
\(\text {DRTOP}\): deep learning-based radiomics for the time-to-event outcome prediction in lung cancer

Parnian Afshar
Arash Mohammadi
Anastasia Oikonomou
ResearchOpen Access23 Jul 2020
Scientific Reports

Volume: 10, P: 1-15
Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth

Focal adhesion kinase (FAK) is required for tumour angiogenesis and growth. Here, the authors show that deletion of pericyte FAK upregulates Gas6-Axl mediated Cyr61 production, which increases endothelial cell proliferation and angiogenesis, while elevating tissue factor production to enhance tumour cell proliferation.

Tanguy Lechertier
Louise E. Reynolds
Kairbaan M. Hodivala-Dilke
ResearchOpen Access04 Jun 2020
Nature Communications

Volume: 11, P: 1-14
Menin inhibition suppresses castration-resistant prostate cancer and enhances chemosensitivity

Chaïma Cherif
Dang Tan Nguyen
Palma Rocchi
ResearchOpen Access28 Oct 2021
Oncogene

Volume: 41, P: 125-137
IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms

Tencho Tenev
Anna Zachariou
Pascal Meier
Research05 Dec 2004
Nature Cell Biology

Volume: 7, P: 70-77
The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis

Rebecca Wilson
Lakshmi Goyal
Pascal Meier
Research14 May 2002
Nature Cell Biology

Volume: 4, P: 445-450
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Investigating Parkinson’s disease risk across farming activities using data mining and large-scale administrative health data

Pascal Petit
François Berger
Nicolas Vuillerme
ResearchOpen Access08 Jan 2025
npj Parkinson's Disease

Volume: 11, P: 1-11
The temperature sensor TWA1 is required for thermotolerance in Arabidopsis

TWA1 is a temperature-sensing transcriptional co-regulator that is needed for basal and acquired thermotolerance in Arabidopsis thaliana.

Lisa Bohn
Jin Huang
Erwin Grill
ResearchOpen Access15 May 2024
Nature

Volume: 629, P: 1126-1132
Comparison of mycophenolate mofetil and calcineurin inhibitor versus calcineurin inhibitor-based graft-versus-host-disease prophylaxis for matched unrelated donor transplant in acute myeloid leukemia. A study from the ALWP of the EBMT

Annalisa Paviglianiti
Myriam Labopin
Mohamad Mohty
Research28 Nov 2020
Bone Marrow Transplantation

Volume: 56, P: 1077-1085
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

SMYD3 is a methyltransferase overexpressed in several human tumours; here methylation of the MAP3K2 kinase by SMYD3 is shown to be critical for Ras-induced tumour development in mouse models and human tumour cells, showing an unexpected role for methylation in a kinase signalling pathway and revealing a candidate therapeutic target.

Pawel K. Mazur
Nicolas Reynoird
Or Gozani
Research21 May 2014
Nature

Volume: 510, P: 283-287
The CINSARC signature predicts the clinical outcome in patients with Luminal B breast cancer

Anthony Goncalves
Pascal Finetti
François Bertucci
ResearchOpen Access05 May 2021
npj Breast Cancer

Volume: 7, P: 1-9
Corporeal Compression at the Onset of Septic shock (COCOONs): a compression method to reduce fluid balance of septic shock patients

Auguste Dargent
Audrey Large
Abderrahmane Bourredjem
ResearchOpen Access09 Aug 2019
Scientific Reports

Volume: 9, P: 1-8
Automated volumetric radiomic analysis of breast cancer vascularization improves survival prediction in primary breast cancer

Matthias Dietzel
Rüdiger Schulz-Wendtland
Pascal A. T. Baltzer
ResearchOpen Access28 Feb 2020
Scientific Reports

Volume: 10, P: 1-11
Contradictory mRNA and protein misexpression of EEF1A1 in ductal breast carcinoma due to cell cycle regulation and cellular stress

Cheng-Yu Lin
Alexandra Beattie
Pascal H. G. Duijf
ResearchOpen Access17 Sept 2018
Scientific Reports

Volume: 8, P: 1-12
Linking plant and vertebrate species to Nature’s Contributions to People in the Swiss Alps

Pierre-Louis Rey
Pascal Vittoz
Antoine Guisan
ResearchOpen Access05 May 2023
Scientific Reports

Volume: 13, P: 1-15
The High Radiosensitizing Efficiency of a Trace of Gadolinium-Based Nanoparticles in Tumors

Sandrine Dufort
Géraldine Le Duc
Olivier Tillement
ResearchOpen Access14 Jul 2016
Scientific Reports

Volume: 6, P: 1-8
ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer

Avais M. Daulat
Pascal Finetti
François Bertucci
ResearchOpen Access11 Apr 2019
British Journal of Cancer

Volume: 120, P: 931-940
Prognostic factors in neuroendocrine carcinoma: biological markers are more useful than histomorphological markers

Patricia Freis
Emmanuelle Graillot
Thomas Walter
ResearchOpen Access11 Jan 2017
Scientific Reports

Volume: 7, P: 1-8
Reduced venetoclax exposure to 7 days vs standard exposure with hypomethylating agents in newly diagnosed AML patients

Christophe Willekens
Alexandre Bazinet
Courtney DiNardo
ResearchOpen Access17 Apr 2025
Blood Cancer Journal

Volume: 15, P: 1-8
The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles

In addition to their role in apoptosis, caspases are also involved in mediating non-apoptotic events. Here the authors show that the Drosophilamyosin family member CRINKLED and its mammalian counterpart act as substrate adaptor that facilitate caspase-mediated cleavage and localised kinase activity.

Mariam H. Orme
Gianmaria Liccardi
Pascal Meier
ResearchOpen Access10 Mar 2016
Nature Communications

Volume: 7, P: 1-12
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity

In this Review, Meier et al. discuss the molecular mechanisms of necroptosis, delineate how this form of immunogenic cell death activates antitumour immune responses and explore the opportunities and limitations of targeting necroptosis for anticancer therapy.

Pascal Meier
Arnaud J. Legrand
John Silke
Reviews07 Mar 2024
Nature Reviews Cancer

Volume: 24, P: 299-315
Transcript-targeted antigen mapping reveals the potential of POSTN splicing junction epitopes in glioblastoma immunotherapy

Zujian Xiong
Chaim T. Sneiderman
Gary Kohanbash
Research03 Apr 2025
Genes & Immunity

Volume: 26, P: 190-199
Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

CAR T cells administered intracerebroventricularly or intratumorally exhibit more rapid kinetics, reduced systemic toxicity and greater therapeutic potency as compared to intravenously delivered CAR T cells in atypical teratoid/rhabdoid tumor xenograft mouse models.

Johanna Theruvath
Elena Sotillo
Crystal L. Mackall
Research27 Apr 2020
Nature Medicine

Volume: 26, P: 712-719
Toxic iron species in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome

Marlijn Hoeks
Tim Bagguley
L. Bond
ResearchOpen Access18 Sept 2020
Leukemia

Volume: 35, P: 1745-1750
Author Correction: Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth

Tanguy Lechertier
Louise E. Reynolds
Kairbaan M. Hodivala-Dilke
Amendments and CorrectionsOpen Access06 Sept 2023
Nature Communications

Volume: 14, P: 1
IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer

The inhibitor of apoptosis (IAP) proteins were first investigated because of their capacity to inhibit programmed cell death in response to a number of physiological stimuli. Their disruption is also evident in many types of human cancer. As small pharmacological inhibitors of IAPs enter clinical trials, this Review examines what we now know about the function of a subset of family members — cIAP1, cIAP2 and XIAP.

Mads Gyrd-Hansen
Pascal Meier
Reviews01 Aug 2010
Nature Reviews Cancer

Volume: 10, P: 561-574

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