Nature Search

The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

Mathieu Miron
Javier Verdú
Nahum Sonenberg
Research17 May 2001
Nature Cell Biology

Volume: 3, P: 596-601
Silicate precursor silane detected in cold low-metallicity brown dwarf

Silane, which is a precursor to the sandy surfaces of rocky planets and dusty clouds on gas giants, is seen directly in another world—a low-metallicity brown dwarf in which oxidation is slow and gas mixing is fast.

Jacqueline K. Faherty
Aaron M. Meisner
Eduardo L. Martin
Research20 Aug 2025
Nature

Volume: 645, P: 62-66
Cystathionase Deficiency: Evidence for Genetic Heterogeneity in Primary Cystathioninuria

Theresa A Pascal
Gerald E Gaull
Harris H Tallan
Research01 Feb 1978
Pediatric Research

Volume: 12, P: 125-133
Permanent correction of an inherited ectodermal dysplasia with recombinant EDA

Olivier Gaide
Pascal Schneider
Research07 Apr 2003
Nature Medicine

Volume: 9, P: 614-618
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation

Tuft cells constitutively express IL-25 to sustain ILC2 homeostasis in the intestine, but mechanisms driving IL-25 secretion have been unclear. Here, Feng et al. find that tuft cells express IL-17RB, which is required to regulate the bioavailability of IL-25 and to restrain the activation of ILC2s during homeostasis.

Xiaogang Feng
Tilde Andersson
Christoph Schneider
ResearchOpen Access12 Mar 2025
Nature Immunology

Volume: 26, P: 567-581
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary statistics from diverse populations.

Aude Nicolas
Richard Sherva
Jean-Charles Lambert
ResearchOpen Access18 Jun 2025
Nature Genetics

Volume: 57, P: 1598-1610
The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors

The immune system tailors its responses according to the level of threat. Lemaitre and colleagues identify a novel version of the peptidoglycan receptor PGRP-LC and demonstrate that it tunes immune responses to live (threatening) or dead (harmless) bacteria.

Claudine Neyen
Christopher Runchel
Bruno Lemaitre
Research22 Aug 2016
Nature Immunology

Volume: 17, P: 1150-1158
Stabilization of sea urchin flagellar microtubules by histone H1

Luc Multigner
Jean Gagnon
Didier Job
Research05 Nov 1992
Nature

Volume: 360, P: 33-39
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
The ESCRT machinery regulates the secretion and long-range activity of Hedgehog

A new role for the endosomal sorting complex required for transport (ESCRT) is identified in fly larvae, where it is shown to be essential for the secretion and long-range signalling of the embryonic development morphogen Hedgehog.

Tamás Matusek
Franz Wendler
Pascal P. Thérond
Research03 Dec 2014
Nature

Volume: 516, P: 99-103
Reorganization of α-fodrin induced by stimulation in secretory cells

Dominique Perrin
Dominique Aunis
Research13 Jun 1985
Nature

Volume: 315, P: 589-592
DNH deoxyribonucleohelicates: self assembly of oligonucleosidic double-helical metal complexes

Ulrich Koert
Margaret M. Harding
Jean-Marie Lehn
Research26 Jul 1990
Nature

Volume: 346, P: 339-342
Author Correction: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome

Marc Janier
Mohammed Almadjub
Madhuri Warren
Amendments and Corrections15 Feb 2022
Nature Genetics

Volume: 54, P: 358-360
The burden of heat-related mortality attributable to recent human-induced climate change

Current and future climate change is expected to impact human health, both indirectly and directly, through increasing temperatures. Climate change has already had an impact and is responsible for 37% of warm-season heat-related deaths between 1991 and 2018, with increases in mortality observed globally.

A. M. Vicedo-Cabrera
N. Scovronick
A. Gasparrini
Research31 May 2021
Nature Climate Change

Volume: 11, P: 492-500
Impact of population aging on future temperature-related mortality at different global warming levels

This study reveals that population aging intensifies heat- and cold-related deaths, more so than climate change, in 50 countries. At 1.53 °C global warming, aging contributes to rising heat-related deaths, offsetting declines in cold related death.

Kai Chen
Evan de Schrijver
Ana M. Vicedo-Cabrera
ResearchOpen Access27 Feb 2024
Nature Communications

Volume: 15, P: 1-13
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

Margot Thome
Pascal Schneider
Jürg Tschopp
Research03 Apr 1997
Nature

Volume: 386, P: 517-521
Next generation genetically encoded fluorescent sensors for serotonin

Genetically encoded sensors have been developed and become versatile tools for imaging serotonin dynamics. Here, authors developed a family of serotonin (5-HT) sensors (sDarken), three variants with different affinities for 5-HT enable high spatiotemporal resolution of 5-HT dynamics.

Martin Kubitschke
Monika Müller
Olivia Andrea Masseck
ResearchOpen Access06 Dec 2022
Nature Communications

Volume: 13, P: 1-17
The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis

Rebecca Wilson
Lakshmi Goyal
Pascal Meier
Research14 May 2002
Nature Cell Biology

Volume: 4, P: 445-450
Spindle assembly checkpoint inactivation fails to suppress neuroblast tumour formation in aurA mutant Drosophila

Drosophila aurA mutants develop brain tumours which are associated with defective mitotic spindle assembly. Caous et al. show that these mutants are surprisingly insensitive to tumour-suppressive spindle assembly checkpoint inactivation, due to a checkpoint-independent delay in cyclin B degradation.

Renaud Caous
Aude Pascal
Régis Giet
ResearchOpen Access16 Nov 2015
Nature Communications

Volume: 6, P: 1-9
Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex

In Drosophila, protein kinase A (PKA) phosphorylates the transcription factor Cubitus interruptus (Ci) in the absence of Hedgehog signalling and the transducer Smoothened in its presence. Here, the authors investigate the mechanism underlying this switch and propose that Smoothened outcompetes Ci for association with PKA on Hedgehog signalling activation.

Nadia Ranieri
Pascal P. Thérond
Laurent Ruel
Research07 Oct 2014
Nature Communications

Volume: 5, P: 1-14
Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations

A large-scale CRISPR-mediated deep mutational scanning approach is used to interrogate the function of mutations in the endogenous locus of TP53 mapping to the DNA-binding domain.

Julianne S. Funk
Maria Klimovich
Thorsten Stiewe
ResearchOpen Access07 Jan 2025
Nature Genetics

Volume: 57, P: 140-153
APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans

The heparan sulfate proteoglycan-binding cytokine APRIL has a protective role against atherosclerotic disease.

Dimitrios Tsiantoulas
Mahya Eslami
Christoph J. Binder
Research25 Aug 2021
Nature

Volume: 597, P: 92-96
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors

BAFF is an important cytokine for B cell survival, and is a therapeutic target for autoimmune disorders. Here the authors show that a 'flap' region of BAFF converts BAFFR binding events into survival signals and, with structural data, that this ‘flap’ differentially modulates binding of drugs such as belimumab or atacicept.

Michele Vigolo
Melissa G. Chambers
Pascal Schneider
ResearchOpen Access23 Mar 2018
Nature Communications

Volume: 9, P: 1-15
A cross-sectional analysis of meteorological factors and SARS-CoV-2 transmission in 409 cities across 26 countries

Possible effects of weather conditions on COVID-19 transmission are debated. Here, the authors analyse data from early in the pandemic and show that although temperature and humidity had small effects on transmission, they were far out-weighed by the effects of non-pharmaceutical interventions.

Francesco Sera
Ben Armstrong
Rachel Lowe
ResearchOpen Access13 Oct 2021
Nature Communications

Volume: 12, P: 1-11
Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens

Phosphatidylserine-exposing extracellular vesicles in body fluids can inhibit infection of viruses that use viral apoptotic mimicry for infection, but not viruses that use other entry mechanisms.

Rüdiger Groß
Hanna Reßin
Janis A. Müller
ResearchOpen Access25 Mar 2024
Nature Microbiology

Volume: 9, P: 905-921
The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles

In addition to their role in apoptosis, caspases are also involved in mediating non-apoptotic events. Here the authors show that the Drosophilamyosin family member CRINKLED and its mammalian counterpart act as substrate adaptor that facilitate caspase-mediated cleavage and localised kinase activity.

Mariam H. Orme
Gianmaria Liccardi
Pascal Meier
ResearchOpen Access10 Mar 2016
Nature Communications

Volume: 7, P: 1-12
Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

Laurent Ruel
Ralph Rodriguez
Pascal P. Thérond
Research01 Oct 2003
Nature Cell Biology

Volume: 5, P: 907-913
Cortical reorganization in motor cortex after graft of both hands

Pascal Giraux
Angela Sirigu
Jean-Michel Dubernard
Research01 Jul 2001
Nature Neuroscience

Volume: 4, P: 691-692
Complex formation of APP with GABA_B receptors links axonal trafficking to amyloidogenic processing

The mechanisms that control the presynaptic abundance of GABAB receptors (GBRs) remains unclear. This study shows that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GBRs, and that selective loss of APP impaired GBR-mediated presynaptic inhibition and axonal GBR expression

Margarita C. Dinamarca
Adi Raveh
Bernhard Bettler
ResearchOpen Access22 Mar 2019
Nature Communications

Volume: 10, P: 1-17
Perfect absorption in nanotextured thin films via Anderson-localized photon modes

Researchers use Anderson localization in nanotextured amorphous silicon and demonstrate enhanced absorption of light.

Martin Aeschlimann
Tobias Brixner
Philip Thielen
Research31 Aug 2015
Nature Photonics

Volume: 9, P: 663-668
C₃-symmetric peptide scaffolds are functional mimetics of trimeric CD40L

Sylvie Fournel
Sébastien Wieckowski
Gilles Guichard
Research06 Nov 2005
Nature Chemical Biology

Volume: 1, P: 377-382
TRAIL receptor-2 signals apoptosis through FADD and caspase-8

Jean-Luc Bodmer
Nils Holler
Jürg Tschopp
Research13 Mar 2000
Nature Cell Biology

Volume: 2, P: 241-243
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

The mechanisms controlling excessive inflammatory responses, which can result in damage to tissues and diseases such as arthritis and type-2 diabetes, are poorly understood. Mouse effector and memory CD4⁺ T cells are now shown to inhibit inflammasome activity, revealing a mechanism by which effector and memory T cells can suppress potentially damaging inflammation while leaving the primary inflammatory response intact.

Greta Guarda
Catherine Dostert
Jürg Tschopp
Research03 Jun 2009
Nature

Volume: 460, P: 269-273
Inhibition of death receptor signals by cellular FLIP

Martin Irmler
Margot Thome
Jürg Tschopp
Research10 Jul 1997
Nature

Volume: 388, P: 190-195
T-cell epitope mapping by flow cytometry

Florian Kern
Ingolf Pascal Surel
Hans-Dieter Volk
Advertorial01 Aug 1998
Nature Medicine

Volume: 4, P: 975-978
Truncated LKB1 nonenzymatically enhances Fas-induced apoptosis by acting as a surrogate of Smac

Yutaro Yamada
Mei Tsuchida
Atsushi Matsuzawa
ResearchOpen Access21 Jun 2025
Cell Death Discovery

Volume: 11, P: 1-14
Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

Nils Holler
Rossana Zaru
Jürg Tschopp
Research01 Dec 2000
Nature Immunology

Volume: 1, P: 489-495
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

Previous studies identified an association between the 2q35 locus and breast cancer. Here, the authors show that a SNP at 2q35, rs4442975, is associated with oestrogen receptor positive disease and suggest that this effect is mediated through the downregulation of a known breast cancer gene, IGFBP5.

Maya Ghoussaini
Stacey L. Edwards
Anna De Fazio
Research23 Sept 2014
Nature Communications

Volume: 5, P: 1-12
Tuft cells in the intestine, immunity and beyond

Tuft cells have important roles in type 2 immunity and antimicrobial responses in mucosal tissues. This Review provides an overview of intestinal tuft cells, providing insights into their phenotype, function and role in the intestine in immunity and other states.

Xiaogang Feng
Pascal Flüchter
Christoph Schneider
Reviews26 Sept 2024
Nature Reviews Gastroenterology & Hepatology

Volume: 21, P: 852-868
Classification of GBA1 variants and their impact on Parkinson’s disease: an in silico score analysis

Aymeric Lanore
Christelle Tesson
Eva Camgrand
ResearchOpen Access02 Aug 2025
npj Parkinson's Disease

Volume: 11, P: 1-14
Jürg Tschopp 1951–2011

Ralph C Budd
Pascal Schneider
Andreas Strasser
Comments & Opinion19 Apr 2011
Nature Immunology

Volume: 12, P: 367
The interactome of a family of potential methyltransferases in HeLa cells

Valentina V. Ignatova
Pascal W. T. C. Jansen
Robert Schneider
ResearchOpen Access29 Apr 2019
Scientific Reports

Volume: 9, P: 1-9
Conformational Analysis of Stereoisomers of Triphenylheptane by Depolarized Rayleigh Scattering

Georges Fourche
Bruno Jasse
Pierre Maelstaf
Research01 Nov 1977
Polymer Journal

Volume: 9, P: 537-539
Remote Tracking of Phase Changes in Cr₂AlC Thin Films by In-situ Resistivity Measurements

Bastian Stelzer
Xiang Chen
Jochen M. Schneider
ResearchOpen Access04 Jun 2019
Scientific Reports

Volume: 9, P: 1-7
Self-passivating (Re,Al)B₂ coatings synthesized by magnetron sputtering

Pascal Bliem
Stanislav Mráz
Jochen M. Schneider
ResearchOpen Access22 Oct 2018
Scientific Reports

Volume: 8, P: 1-6
Functional analysis of Ectodysplasin-A mutations causing selective tooth agenesis

Gabriele Mues
Aubry Tardivel
Rena N D'Souza
Research22 Jul 2009
European Journal of Human Genetics

Volume: 18, P: 19-25
IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms

Tencho Tenev
Anna Zachariou
Pascal Meier
Research05 Dec 2004
Nature Cell Biology

Volume: 7, P: 70-77
Post-eruptive flooding of Santorini caldera and implications for tsunami generation

The Bronze Age eruption of Santorini is known to have generated tsunamis with caldera collapse as the likely mechanism. However, new bathymetric and seismic data presented by Nomikou et al. show that the entry of pyroclastic flows into the sea is the most likely tsunami-generating mechanism at Santorini.

P. Nomikou
T. H. Druitt
M. M. Parks
ResearchOpen Access08 Nov 2016
Nature Communications

Volume: 7, P: 1-10
The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells

A multi-omics approach was used to identify a new antiviral cascade, Hsf1-sHsp, that exhibits broad antiviral activity against alphaviruses and a flavivirus in cells from three vector mosquito species.

Jieqiong Qu
Michelle Schinkel
Ronald P. van Rij
ResearchOpen Access25 Jan 2025
Communications Biology

Volume: 8, P: 1-9
Epigenetic markers of disease risk and psychotherapy response in anxiety disorders – a longitudinal analysis of the DNA methylome

Katharina Domschke
Miriam A. Schiele
Jürgen Deckert
ResearchOpen Access25 Apr 2025
Molecular Psychiatry

Volume: 30, P: 4529-4542

Search

Filter By:

Search

Quick links