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Showing 1–4 of 4 results
Advanced filters: Author: Pascale Lemieux Clear advanced filters

  • Gene duplication is a key evolutionary mechanism, as initially redundant paralogues diverge over time. The authors review how adaptive and non-adaptive forces influence the evolutionary fates of gene duplicates, highlighting the importance of function–fitness relationships and gene expression dynamics.

    • Angel F. Cisneros
    • Soham Dibyachintan
    • Christian R. Landry
    Reviews
    Nature Reviews Genetics
    P: 1-18

  • Over time, paralogous genes accumulate changes in their sequences that do not affect their function, which is called cryptic variation. Using paralogous myosins, this study shows how cryptic variation modulates the functional effect of mutations and biases duplicates to distinct evolutionary fates.

    • Soham Dibyachintan
    • Alexandre K. Dubé
    • Christian R. Landry
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

    • Jacob Beal
    • Natalie G. Farny
    • Jiajie Zhou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-29