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Alcohol use disorder drives transcriptional and regulatory changes in the caudate nucleus. Here, authors show, using a single-cell multiomic analysis, cell type-specific disruptions of gene expression, chromatin accessibility, and cell communication.

2023 CX1 is the only L-chondrite-like asteroid analysed from space to ground. It catastrophically fragmented in the atmosphere, depositing 98% of its energy in one burst—an unusual, high-risk fragmentation mode with implications for planetary defence.

Santos et al found that the ubiquitin ligase adaptor Fbxo42 is a critical regulator of terminal Unfolded Protein Response signaling through its control of Ataxin-2 granules containing Xbp1 mRNA.

Cet ancien amendement pour sols est prometteur pour les récoltes, à condition de mettre en place les politiques et les investissements appropriés et de sensibiliser les agriculteurs.

3D correlative nanoscale tomography on an Fe-W alloy shows that topology requires secondary grain boundary dislocations which strongly control patterned solute segregation, reshaping segregation energy spectra and opening routes for advanced alloy design.

The authors report subnanosecond thermal transport on a gold–hexagonal boron nitrite interface governed by hyperbolic phonon–polariton coupling, demonstrating a cooling mechanism orders of magnitude faster than those relying on phonon-mediated processes.

African ancestry is a known risk factor for prostate cancer development, but the genetic determinants of this are incompletely understood. Here, the authors identify 172 potentially pathogenic variants which are enriched in an African population.

This study reveals how human small ubiquitin-like modifier (SUMO) E1 recruits its E2 partner UBC9 and transfers SUMO1 through large structural changes, uncovering key mechanisms that ensure specificity and fidelity in SUMOylation, an essential protein modification pathway.

A transiting planet with a period of about 8.5 days and a radius 0.4 times that of Jupiter is reported within the debris disk around the star AU Microscopii.

Ancient soil enhancer holds promise for harvests, with right policy, investment, and farmers awareness.

Biomolecular condensates are made of multiple components but current techniques cannot capture their complex composition quantitatively. Now it has been shown that the dense-phase binodal point defining the composition of multicomponent condensates can be inferred precisely from the intersection of a spectrometrically determined tie-line with an isorefractive line obtained from quantitative phase imaging.

Implant-associated infections with Staphylococcus aureus pose serious clinical challenges. Here, the authors develop a biosensor based on toxin-responsive liposomes encapsulating gold nanoclusters, providing a non-invasive, colourimetric diagnostic tool for bacterial infection detection with urinary readout.

Mononuclear gold(II) complexes are very labile (and thus very rare) species. Now, a gold(II) porphyrin complex has been isolated and characterized, and its reactivity towards dioxygen, nitrosobenzene and acids investigated. Owing to a second-order Jahn–Teller distortion, the gold atoms were found to adopt a 2+2 coordination mode in a planar N₄ environment.

BindCraft, an open-source, automated pipeline for de novo protein binder design with experimental success rates of 10–100%, leverages AlphaFold2 weights to generate binders with nanomolar affinity without the need for high-throughput screening.

The detailed nucleation and growth kinetics and the crystal structure of catalytically relevant CoPt₃/Au, FePt/Au and Pt/Au metal dumbbell nanoparticles have been obtained by in situ synchrotron small- and wide-angle X-ray scattering techniques.

Proxies for evolutionary processes are widely employed to inform environmental management, conservation, and ecological restoration. This study shows that as proxies, bioregionalisations and floristic classification, do not reflect intraspecific evolutionary patterns observed in targeted genetic studies.

Antibiotic resistance poses a critical global health threat. Here, the authors identify a carbapenem resistant clone of uropathogenic Escherichia coli with atypical virulence features as an increasing cause of urinary tract infection

GHIST is a deep learning-based method that can predict spatial gene expression at high resolution using histology data.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

A model with a more plausible collision scenario explains the formation of Mercury through a giant impact between two bodies of similar size. The model also obtains very accurate results in terms of the iron core-mass fraction.

When a plasma interacts with a surface, different thermal effects may arise. Here, the authors explore plasma interactions with a surface that produce a surface cooling effect.

Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

Climate change threatens mountain ash (Eucalyptus regnans) forests, which are among Earth’s most carbon-dense ecosystems. This study finds that a projected 3^∘C warming by 2080 could reduce tree density and carbon storage in these forests by 24%

Thermal stress near the Sun and Earth’s atmosphere remove weaker meteoroids, explaining the rarity of carbon-rich meteorites despite abundant carbon-rich asteroids, thus resolving a long-standing mismatch in Earth’s meteorite record.

Label-free surface-enhanced Raman spectroscopy is an emergent method for the detection and discrimination of biological analytes. Here, the authors describe SERS sensors with arrayed mildly-selective surface chemistries to give a fingerprint based on different interactions for analysing biological samples.

Magic-number Au₁₁ clusters containing N-heterocyclic carbene (NHC) ligands are prepared by ligand exchange on known phosphine clusters and the introduction of even a single NHC results in improved cluster stability. The use of NHC-containing clusters in the electrocatalytic reduction of CO₂ to CO is described and correlates with cluster stability.

The M₅ muscarinic acetylcholine receptor represents a promising therapeutic target for neurological disorders. Here, the authors reveal a 2.1 Å cryo-EM structure of the M₅ bound to a selective positive allosteric modulator site that enables structure-based drug design.

Molecular glue degraders eliminate cellular proteins by promoting their interaction with E3 ubiquitin ligases. Here, the authors identify molecular glue degraders targeting the E3 ligase TRIM21 and synthesize a heterobifunctional degrader that recruits TRIM21 to degrade an engineered protein aggregate.

Spin-waves have a variety of advantages for information processing, and here, Chen, Xu and coauthors demonstrate the deterministic switching of antiferromagnetic spin textures using non-linear spin-waves. The switching process is progressive, mirroring weighted sum operations in neuromorphic computing.

Here, the authors report on the thermal and mechanical properties of Ruddlesden-Popper phases (Ban+1ZrnS3n+1, n = 2 and 3) of a perovskite chalcogenide (BaZrS3) that push to extreme limits and defy the century-old relation between thermal conductivity and interatomic bond strength.

Although bulk defects can influence the performance of electrocatalysts used for energy conversion, their structural origins are still unclear. The effects of bulk defects on CO₂ electroreduction and H₂ evolution activity on Au electrodes are now elucidated.

2D devices with negative differential resistance are desired for multivalued logic applications, but they are normally limited by low current densities and operational frequency. Here, the authors report graphene/hexagonal boron nitride/graphene resonant tunnelling transistors with room temperature peak current density up to 2700 μA/μm² and operational frequencies up to 11 GHz.

This large meta-analysis of 11 GWAS identified 7 genetic loci associated with strabismus, esotropia and exotropia. Mendelian randomisation provided genetic evidence of the causal link between maternal smoking to increased strabismus risk in offspring.

Peptoids are promising crystallization agents, as they offer the molecular recognition capabilities of proteins and peptides but with higher stability and synthetic tunability. Here, the authors show that sequence-defined peptoids can controllably template the formation and shape evolution of gold nanostructures with defined morphologies.

Double Asteroid Redirection Test (DART) mission’s impact on asteroid Dimorphos has led to various impact related features. Here, the authors show that those features result naturally from the dynamical interaction of the ejecta with the binary system and solar radiation pressure.

Direct detection of gas phase water from the disk of V883 Ori indicates that disks directly inherit water from the star-forming cloud that becomes incorporated into large icy bodies without notable chemical alteration.

Detection of electric fields, central to chemical and biological processes, has been limited to measurements of current (e.g., electrodes) and secondary reporters (e.g., fluorescent dyes). Here, the authors demonstrate an optical platform capable of imaging electric field dynamics with high spatio-temporal resolution.

Here they show that HDAC6 inhibition regulates fumarate hydratase (FH), disrupts mitochondria, increases fumarate, and causes cancer cell death. This suggests that HDAC6 inhibition could be a strategy to target tumour metabolism indirectly.

Unconventional quasiparticles carrying spin but not electric charge emerge in quantum spin liquid phases. The Kondo interaction of these spinon quasiparticles with magnetic impurities may now have been observed.

The primary challenge in commercializing perovskite solar cells stems from the fragile and moisture-sensitive nature of perovskite materials. Here, authors propose a multi-functional asynchronous cross-linking strategy and achieve high-performance and stable devices with mere 0.30 voltage deficit.

A giant planet candidate roughly the size of Jupiter but more than 14 times as massive is observed by TESS and other instruments to be transiting the white dwarf star WD 1856+534.