Nature Search

Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Maximilian Zenk
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Arterial stiffness and vascular aging: mechanisms, prevention, and therapy

Maximilian Jonathan Herzog
Patrick Müller
Ruediger C. Braun-Dullaeus
ReviewsOpen Access01 Sept 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-33
Precise through-space control of an abiotic electrophilic aromatic substitution reaction

Regioselectivity during electrophilic aromatic substitution is typically controlled by substituents on the aryl group. Here the authors report an electrophilic aromatic substitution reaction, wherein remote chiral ester groups direct the electrophile to a precise location on the molecule.

Kyle E. Murphy
Jessica L. Bocanegra
Severin T. Schneebeli
ResearchOpen Access05 Apr 2017
Nature Communications

Volume: 8, P: 1-7
Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72

The most common genetic cause of ALS and frontal temporal dementia—hexanucleotide repeat expansion in C9orf72—is shown to provoke disease via synergy of gain of toxicity(ies) from repeat-encoded RNAs/dipeptide repeat proteins and reduction in the C9ORF72 protein.

Qiang Zhu
Jie Jiang
Don W. Cleveland
Research13 Apr 2020
Nature Neuroscience

Volume: 23, P: 615-624
A specific requirement for PDGF-C in palate formation and PDGFR-α signaling

Hao Ding
Xiaoli Wu
Andras Nagy
Research07 Sept 2004
Nature Genetics

Volume: 36, P: 1111-1116
Federated learning enables big data for rare cancer boundary detection

Federated ML (FL) provides an alternative to train accurate and generalizable ML models, by only sharing numerical model updates. Here, the authors present the largest FL study to-date to generate an automatic tumor boundary detector for glioblastoma.

Sarthak Pati
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access05 Dec 2022
Nature Communications

Volume: 13, P: 1-17
Deep mitigation of CO₂ and non-CO₂ greenhouse gases toward 1.5 °C and 2 °C futures

Stabilizing climate change requires simultaneous mitigation of all greenhouse gas emissions (GHGs). Here the authors examine 90 mitigation scenarios pairing different levels of CO₂ and non-CO₂ GHG abatement pathways to demonstrate the contributions of different GHGs towards 1.5 °C and 2 °C goals.

Yang Ou
Christopher Roney
Haewon McJeon
ResearchOpen Access29 Oct 2021
Nature Communications

Volume: 12, P: 1-9
Drivers and implications of alternative routes to fuels decarbonization in net-zero energy systems

Assumptions about the use of biomass and CO₂ sequestration drive key differences in how emissions from remaining fuels are mitigated in net-zero energy systems, with potentially significant tradeoffs that will need to be evaluated and managed.

Bryan K. Mignone
Leon Clarke
Aranya Venkatesh
ResearchOpen Access10 May 2024
Nature Communications

Volume: 15, P: 1-14
Source sector and fuel contributions to ambient PM_2.5 and attributable mortality across multiple spatial scales

Ambient fine particulate matter (PM_2.5) is one of the most important environmental health risk factors in many regions. Here, the authors present an assessment of PM_2.5 emission sources and the related health impacts across global to sub-national scales and find that over 1 million deaths were avoidable in 2017 by eliminating PM_2.5 mass associated with fossil fuel combustion emissions.

Erin E. McDuffie
Randall V. Martin
Michael Brauer
ResearchOpen Access14 Jun 2021
Nature Communications

Volume: 12, P: 1-12
Phase-fluctuating superconductivity in overdoped La_2−xSr_xCuO₄

Superconducting phase fluctuations are often associated with the pseudogap phase of the copper-oxide superconductors. However, the same fluctuations exist in the overdoped part of the phase diagram where the pseudogap is absent, suggesting that phase fluctuations are independent of the pseudogap

Patrick M. C. Rourke
Ioanna Mouzopoulou
Nigel E. Hussey
Research13 Mar 2011
Nature Physics

Volume: 7, P: 455-458
Accurate whole human genome sequencing using reversible terminator chemistry

David R. Bentley
Shankar Balasubramanian
Anthony J. Smith
ResearchOpen Access06 Nov 2008
Nature

Volume: 456, P: 53-59
The ubiquitin ligase COP1 is a critical negative regulator of p53

David Dornan
Ingrid Wertz
Vishva M. Dixit
Research21 Apr 2004
Nature

Volume: 429, P: 86-92
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

The authors define molecular mechanisms by which distinct domains of the ubiquitin editing enzyme A20 contribute to the regulation of inflammation and cell death.

Ingrid E. Wertz
Kim Newton
Vishva M. Dixit
Research09 Dec 2015
Nature

Volume: 528, P: 370-375
Bcl-2 acts upstream of the PARP protease and prevents its activation

David K Perry
Miriam J Smyth
Yusuf A Hannun
Research01 Jan 1997
Cell Death & Differentiation

Volume: 4, P: 29-33
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Patrick H. Maxwell
Michael S. Wiesener
Peter J. Ratcliffe
Research20 May 1999
Nature

Volume: 399, P: 271-275
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Exome sequencing and copy number analysis are used to define genomic aberrations in early sporadic pancreatic ductal adenocarcinoma; among the findings are mutations in genes involved in chromatin modification and DNA damage repair, and frequent and diverse somatic aberrations in genes known as embryonic regulators of axon guidance.

Andrew V. Biankin
Nicola Waddell
Sean M. Grimmond
Research24 Oct 2012
Nature

Volume: 491, P: 399-405
Science-policy: UNFCCC policymakers’ perspective of scientific scenarios and their policy relevance

Jiesper Tristan Strandsbjerg Pedersen
Carla Gomes
Rob Swart
ResearchOpen Access23 May 2025
npj Climate Action

Volume: 4, P: 1-16
IDH mutation impairs histone demethylation and results in a block to cell differentiation

Cancer-associated IDH mutants that produce 2-hydroxyglutarate are shown to prevent the histone demethylation that is required for lineage-specific progenitor cells to differentiate into terminally differentiated cells.

Chao Lu
Patrick S. Ward
Craig B. Thompson
Research15 Feb 2012
Nature

Volume: 483, P: 474-478
Whole genomes redefine the mutational landscape of pancreatic cancer

A whole-genome sequencing analysis of 100 pancreatic ductal adenocarcinomas has discovered known and newly identified genetic drivers of pancreatic cancer; these genetic alterations can be classified into four subtypes, which raises the possibility of improved targeting of clinical treatments.

Nicola Waddell
Marina Pajic
Sean M. Grimmond
Research25 Feb 2015
Nature

Volume: 518, P: 495-501
Regulation of phosphatidylserine exposure and phagocytosis of apoptotic T lymphocytes

Bret Verhoven
Stephen Krahling
Patrick Williamson
Research12 Mar 1999
Cell Death & Differentiation

Volume: 6, P: 262-270
Predicting the potential for zoonotic transmission and host associations for novel viruses

Potential host range and spillover risk for novel viruses can be predicted using a network informed by known virus-host associations.

Pranav S. Pandit
Simon J. Anthony
Christine K. Johnson
ResearchOpen Access19 Aug 2022
Communications Biology

Volume: 5, P: 1-10
Residential environmental measurements in the National Human Exposure Assessment Survey (NHEXAS) pilot study in Arizona: preliminary results for pesticides and VOCs

SYDNEY M GORDON
PATRICK J CALLAHAN
DEMETRIOS J MOSCHANDREAS
Research29 Oct 1999
Journal of Exposure Science & Environmental Epidemiology

Volume: 9, P: 456-470
Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

The analysis of T-cell antigens in long-term survivors of pancreatic ductal adenocarcinoma suggests that neoantigen immunogenicity and quality, not purely quantity, correlate with survival.

Vinod P. Balachandran
Marta Łuksza
Steven D. Leach
Research01 Nov 2017
Nature

Volume: 551, P: 512-516
Author Correction: Federated learning enables big data for rare cancer boundary detection

Sarthak Pati
Ujjwal Baid
Spyridon Bakas
Amendments and CorrectionsOpen Access26 Jan 2023
Nature Communications

Volume: 14, P: 1-2
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

An in vivo transposon screen in a pancreatic cancer model identifies frequent inactivation of Usp9x; deletion of Usp9x cooperates with Kras^G12D to accelerate rapidly pancreatic tumorigenesis in mice, validating their genetic interaction.

Pedro A. Pérez-Mancera
Alistair G. Rust
David A. Tuveson
Research29 Apr 2012
Nature

Volume: 486, P: 266-270
Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

Evan Bolyen
Jai Ram Rideout
J. Gregory Caporaso
Correspondence24 Jul 2019
Nature Biotechnology

Volume: 37, P: 852-857
BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway

Adam L. Green
John DeSisto
Rajeev Vibhakar
Research16 Dec 2019
Oncogene

Volume: 39, P: 2305-2327
Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development

Natalie Page
Mark Wappett
Timothy Harrison
ResearchOpen Access20 Sept 2022
Scientific Reports

Volume: 12, P: 1-14
Investigating hypoxic tumor physiology through gene expression patterns

Nicholas C Denko
Lucrezia A Fontana
Amato J Giaccia
Reviews28 Aug 2003
Oncogene

Volume: 22, P: 5907-5914
Overview of the Alliance for Cellular Signaling

Alfred G. Gilman
Melvin I. Simon
Gilberto R. Sambrano
Editorial12 Dec 2002
Nature

Volume: 420, P: 703-706
HER2/Neu: mechanisms of dimerization/oligomerization

Patrick J Brennan
Toru Kumogai
Mark I Greene
Research09 Dec 2000
Oncogene

Volume: 19, P: 6093-6101
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
A first-in-human Phase I dose-escalation trial of the novel therapeutic peptide, ALM201, demonstrates a favourable safety profile in unselected patients with ovarian cancer and other advanced solid tumours

Aya El Helali
Ruth Plummer
Richard H. Wilson
ResearchOpen Access14 May 2022
British Journal of Cancer

Volume: 127, P: 92-101
Author Correction: Predicting the potential for zoonotic transmission and host associations for novel viruses

Pranav S. Pandit
Simon J. Anthony
Christine K. Johnson
Amendments and CorrectionsOpen Access10 Jan 2023
Communications Biology

Volume: 6, P: 1

Search

Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Arterial stiffness and vascular aging: mechanisms, prevention, and therapy

Precise through-space control of an abiotic electrophilic aromatic substitution reaction

Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72

A specific requirement for PDGF-C in palate formation and PDGFR-α signaling

Federated learning enables big data for rare cancer boundary detection

Deep mitigation of CO₂ and non-CO₂ greenhouse gases toward 1.5 °C and 2 °C futures

Drivers and implications of alternative routes to fuels decarbonization in net-zero energy systems

Source sector and fuel contributions to ambient PM_2.5 and attributable mortality across multiple spatial scales

Phase-fluctuating superconductivity in overdoped La_2−xSr_xCuO₄

Accurate whole human genome sequencing using reversible terminator chemistry

The ubiquitin ligase COP1 is a critical negative regulator of p53

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

Bcl-2 acts upstream of the PARP protease and prevents its activation

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Science-policy: UNFCCC policymakers’ perspective of scientific scenarios and their policy relevance

IDH mutation impairs histone demethylation and results in a block to cell differentiation

Whole genomes redefine the mutational landscape of pancreatic cancer

Regulation of phosphatidylserine exposure and phagocytosis of apoptotic T lymphocytes

Predicting the potential for zoonotic transmission and host associations for novel viruses

Residential environmental measurements in the National Human Exposure Assessment Survey (NHEXAS) pilot study in Arizona: preliminary results for pesticides and VOCs

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Author Correction: Federated learning enables big data for rare cancer boundary detection

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway

Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development

Investigating hypoxic tumor physiology through gene expression patterns

Overview of the Alliance for Cellular Signaling

HER2/Neu: mechanisms of dimerization/oligomerization

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

A first-in-human Phase I dose-escalation trial of the novel therapeutic peptide, ALM201, demonstrates a favourable safety profile in unselected patients with ovarian cancer and other advanced solid tumours

Author Correction: Predicting the potential for zoonotic transmission and host associations for novel viruses

Search

Quick links

Search

Filter By:

Search

Quick links