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Showing 1–4 of 4 results

Advanced filters: Author: Paul Balbo Clear advanced filters

Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca²⁺ dependent allosteric binding site

Protein citrullination regulates the physiological function of proteins and is linked to various autoimmune disorders. Here, the authors report on the allosteric targeting of PAD1-4 leading to broad inhibition of protein citrullination in neutrophils.

Leslie A. Dakin
Li Xing
Mark E. Schnute
ResearchOpen Access16 May 2025
Nature Communications

Volume: 16, P: 1-12
A PLAG1 mutation contributed to stature recovery in modern cattle

Yuri Tani Utsunomiya
Marco Milanesi
José Fernando Garcia
ResearchOpen Access07 Dec 2017
Scientific Reports

Volume: 7, P: 1-15
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

Shenping Liu
Leslie A. Dakin
Atli Thorarensen
ResearchOpen Access16 Aug 2016
Scientific Reports

Volume: 6, P: 1-12
The effect of leave policies on increasing fertility: a systematic review

Jac Thomas
Francisco Rowe
Eric S. Lin
ReviewsOpen Access08 Aug 2022
Humanities and Social Sciences Communications

Volume: 9, P: 1-16