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Methods to characterize compound eye optics, from either 2D or 3D data are developed and validated using microscope, SEM, and µCT eye images from ants, fruit flies, moths, and a bee.

New instrumental learning occurs through an unexpected delivery of a rewarding stimulus or the withdrawal of a punishing stimulus. The authors show that D1 receptor-expressing medium spiny neurons (MSNs) in the anterior dorsolateral striatum encode newly learned instrumental actions whereas D2 MSNs promote the expression of habitual actions.

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

The authors show that norepinephrine signaling to astrocytes in the mouse visual cortex acts as a separate neuromodulatory pathway that regulates the effects of arousal on neuronal activity and cortical state.

Recent developments in cryo-electron microscopy have enabled structure determination of large protein complexes at almost atomic resolution. Wang et al.combine some of these technologies into an effective workflow, and demonstrate the protocol by solving the atomic structure of an icosahedral RNA virus.

In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cognitive function and to Parkinson's disease, and enriched near genes involved in growth pathways, including PI3K-AKT signaling.

The authors present an integrated photonic processor for blind source separation (BSS) to address broadband radio-frequency interference issues. The photonic BSS achieves 19.2 GHz processing bandwidth with highly energy-efficient BSS processing of sub-15 nanosecond latency.

Analysis of the pulse profile of a fast radio burst showed sub-second periodicity, providing evidence for a neutron-star origin of the event and favouring emission arising from the magnetosphere.

The real-world object localization application needs a low-latency and power efficient computing system. Here, Moro et al. demonstrate a neuromorphic in-memory event driven system, inspired by the barn owl’s neuroanatomy, which is orders of magnitude more energy efficient than microcontrollers.

White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and drug targeting.

The recently discovered spin-triplet superconductor UTe₂ is found to display a number of other ‘re-entrant’ superconducting phases under ultrahigh magnetic fields.

By coordinating copper ions with the oxygen-containing groups of cellulose nanofibrils, the molecular spacing in the nanofibrils is increased, allowing fast transport of lithium ions and offering hopes for solid-state batteries.

Stable solid–electrolyte interphases on Li anodes are crucial for reliable Li metal batteries. A suspension electrolyte design that modifies the Li⁺ solvation environment in liquid electrolytes and creates inorganic-rich interphases on Li is now reported.

The authors show that spatial frequency domain Fourier power closely but nonlinearly follows numerosity, simplifying computing numerosity from early visual responses. Monotonic early visual cortex and neural network responses follow Fourier power, while later tuned responses follow numerosity.

Interfaces play crucial, but still poorly understood, roles in the performance of secondary solid-state batteries. Using crystallographically oriented and highly faceted thick cathodes, the impact of cathode crystallography and morphology on long-term performance is investigated.

Structural, functional and in silico analyses of the chloroquine-resistance transporter PfCRT of Plasmodium falciparum suggest that distinct mechanistic features mediate the resistance to chloroquine and piperaquine in drug-resistant parasites.

Bloch–Siegert shifts prevent the accurate observation of resonance frequencies in NMR experiments. Here the authors present a method for homonuclear decoupling that avoids inducing Bloch–Siegert shifts and improves the sensitivity and resolution of HNCA experiments.

Silicon is a promising anode material for lithium-ion batteries but experiences large volume changes during cycling. Here the authors report a scalable method to synthesize porous ant-nest-like silicons. The unique structure of this anode solves the swelling problem and enables impressive performance.

With conventional scanning transmission electron microscopy, some sensitive materials are difficult to image with atomic resolution. The authors present a method of mixed-state electron ptychography that enables picometer precision with fast acquisition and low dosage.

Quantifying entanglement in a large quantum system requires an intractable number of measurements. Here, the authors demonstrate a method for certifying entanglement from extremely undersampled data by combining a new quantitative entanglement witness with an adaptive sampling procedure.

Control of the interaction between atoms and their neighbours is important to quantum information processing and has been studied using two states. Here the authors demonstrate a more flexible control using a three-state superposition of donors in silicon using THz quantum beat spectroscopy.

Genome-wide analysis identifies variants associated with the volume of seven different subcortical brain regions defined by magnetic resonance imaging. Implicated genes are involved in neurodevelopmental and synaptic signaling pathways.

The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.

Here the authors use cationic chain transfer agents to prevent degradation of ether electrolytes by arresting uncontrolled polymer growth at the anode. This work provides a fundamental strategy for extending the high voltage stability of these electrolytes to potentials above conventionally accepted limits.

A recently developed computational imaging technique, X-ray ptychographic tomography, is used to study integrated circuits, and a 3D image of a processor chip with a resolution of 14.6 nm is obtained.

Fluorinated elastomers as photoresists in the fabrication of soft neural probes are used to enhance the spatiotemporal recording capability at single-neuron resolution within the central nervous system of rodents.

Derivation of human induced pluripotent stem cells (hiPSCs) produces primed hiPSCs that can in turn be converted to naive hiPSCs. Here, the authors directly reprogram somatic cells to form both naive and primed isogenic hiPSCs and confirm the similarity of naive hiPSCs to their in vivo counterparts.

An increase in the volume of the brain lateral ventricles is a sign of normal aging, but can also be associated with neurological and psychiatric disorders. Here, Vojinovic et al. identify seven genetic loci in a GWA study for ventricular volume in 23,500 individuals and find correlation with thalamus volume.

In multi-layered epithelia tight junctions (TJ) are confined to the most suprabasal viable layer. Here the authors show that this is regulated by ubiquitously localized E-cadherin tuning junctional tension and EGFR activity to inhibit TJ formation in lower layers while promoting TJ stability in the granular layer 2.

An improved version of the green-to-red photoconverting EosPF is presented. mEos2 is a functional fusion partner for many cellular proteins and retains the high localization precision of EosFP in super-resolution imaging. Also in this issue, Subach et al. present an inducible mCherry variant for super-resolution imaging.