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Scientific Reports (20)
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Showing 1–50 of 51 results

Advanced filters: Author: Pei-yuan Qian Clear advanced filters

Reply to: Macrocyclic colibactins

Wenjun Zhang
Pei-Yuan Qian
Research21 Sept 2020
Nature Chemistry

Volume: 12, P: 1007
Publisher Correction: Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases

Yong-Xin Li
Zheng Zhong
Pei-Yuan Qian
Amendments and Corrections07 Mar 2018
Nature Chemical Biology

Volume: 14, P: 901
Decoupling of strain- and intrastrain-level interactions of microbiomes in a sponge holobiont

Marine host-associated microbiomes retain a tremendous pool of genetic diversity, which is key to the health of marine ecosystems. This study on reef sponges shows that genomic diversification of individual microbiomes follows different rules at strain- and intrastrain-levels.

Wenxiu Wang
Weizhi Song
Lu Fan
ResearchOpen Access18 Sept 2024
Nature Communications

Volume: 15, P: 1-17
Marine biofilms constitute a bank of hidden microbial diversity and functional potential

Previous surveys of global ocean microbial diversity have focused on planktonic microbes. Here, Zhang et al. use metagenomics to study biofilm-forming marine microbes, increasing the known microbial diversity in the oceans by more than 20% and revealing new biosynthetic gene clusters and CRISPR-Cas systems.

Weipeng Zhang
Wei Ding
Pei-Yuan Qian
ResearchOpen Access31 Jan 2019
Nature Communications

Volume: 10, P: 1-10
Distinct genomic routes underlie transitions to specialised symbiotic lifestyles in deep-sea annelid worms

Annelid worms have colonised extreme ecological niches, such as hydrothermal vents and whale falls thanks to symbiotic bacteria. This study finds that Osedax worms and the related Vestimentifera have evolved different genomic adaptations to sustain their bacterial symbioses and exploit different resources, such as decaying bone.

Giacomo Moggioli
Balig Panossian
José M. Martín-Durán
ResearchOpen Access17 May 2023
Nature Communications

Volume: 14, P: 1-17
Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage

Colibactin is produced by human enterobacteria and assumed to be a gut bacterial genotoxin. Now, colibactin-645 has been identified as a macrocyclic colibactin metabolite that contains a C-terminal 5-hydroxy-4-oxazolecarboxylic acid moiety and induces DNA double-strand breaks in vitro and in human cell cultures via a unique copper-mediated oxidative mechanism.

Zhong-Rui Li
Jie Li
Pei-Yuan Qian
Research16 Sept 2019
Nature Chemistry

Volume: 11, P: 880-889
Adaptation to deep-sea chemosynthetic environments as revealed by mussel genomes

Genome sequences of a deep-sea vent and a shallow-water mussel species are compared. The former has expanded gene families for protein stabilization and removal of toxic substances and has a more complex immune system.

Jin Sun
Yu Zhang
Pei-Yuan Qian
ResearchOpen Access03 Apr 2017
Nature Ecology & Evolution

Volume: 1, P: 1-7
A novel chresdihydrochalcone from Streptomyces chrestomyceticus exhibiting activity against Gram-positive bacteria

Weiyi She
Wenkang Ye
Pei-Yuan Qian
Research18 Mar 2020
The Journal of Antibiotics

Volume: 73, P: 429-434
Paenialvin A–D, four peptide antibiotics produced by Paenibacillus alvei DSM 29

Jia Meng
Zheng Zhong
Pei-Yuan Qian
Research14 May 2018
The Journal of Antibiotics

Volume: 71, P: 769-777
ADAM9 enhances CDCP1 protein expression by suppressing miR-218 for lung tumor metastasis

Kuo-Liang Chiu
Ting-Ting Kuo
Yuh-Pyng Sher
ResearchOpen Access10 Nov 2015
Scientific Reports

Volume: 5, P: 1-11
Adaptation of intertidal biofilm communities is driven by metal ion and oxidative stresses

Weipeng Zhang
Yong Wang
Pei-Yuan Qian
ResearchOpen Access11 Nov 2013
Scientific Reports

Volume: 3, P: 1-7
Bacterial community succession and chemical profiles of subtidal biofilms in relation to larval settlement of the polychaete Hydroides elegans

Hong Chun Chung
On On Lee
Pei-Yuan Qian
Research21 Jan 2010
The ISME Journal

Volume: 4, P: 817-828
Hologenome analysis reveals dual symbiosis in the deep-sea hydrothermal vent snail Gigantopelta aegis

Symbiotic partners are rarely studied in equal depth. By assembling new genomes, Lan et al. report a novel dual symbiosis in the snail Gigantopelta aegis with two evolutionarily distant gammaproteobacterial endosymbionts: one which oxidises sulfur, the other, methane in a metabolically mutualistic relationship.

Yi Lan
Jin Sun
Pei-Yuan Qian
ResearchOpen Access19 Feb 2021
Nature Communications

Volume: 12, P: 1-15
Mutanofactin promotes adhesion and biofilm formation of cariogenic Streptococcus mutans

The mutanofactin family of lipopeptide natural products, produced by strains of cariogenic Streptococcus mutans, promotes biofilm formation via increased cell-surface hydrophobicity and binding to extracellular DNA.

Zhong-Rui Li
Jin Sun
Wenjun Zhang
Research04 Mar 2021
Nature Chemical Biology

Volume: 17, P: 576-584
The Scaly-foot Snail genome and implications for the origins of biomineralised armour

The Scaly-foot Snail, Chrysomallon squamiferum, is a model for understanding the evolution of biomineralised armour. Here, the authors present a chromosome-level reference genome assembly and tissue-specific transcriptomic data for this enigmatic organism.

Jin Sun
Chong Chen
Pei-Yuan Qian
ResearchOpen Access08 Apr 2020
Nature Communications

Volume: 11, P: 1-12
A Pseudomonas T6SS effector recruits PQS-containing outer membrane vesicles for iron acquisition

Pathogens require iron for their metabolism and virulence. Here the authors identify an iron acquisition system inPseudomonas aeruginosainvolving a protein secreted by a type VI secretion system, the PQS signalling compound and siderophore receptors.

Jinshui Lin
Weipeng Zhang
Xihui Shen
ResearchOpen Access28 Mar 2017
Nature Communications

Volume: 8, P: 1-12
Symbiodiniaceae algal symbionts of Pocillopora damicornis larvae provide more carbon to their coral host under elevated levels of acidification and temperature

Acidification and warming enhance the productivity and nutrient assimilation of Pocillopora damicornis coral larvae, without destabilizing its symbiosis with intracellular algae.

Youfang Sun
Huaxia Sheng
Hui Huang
ResearchOpen Access18 Nov 2024
Communications Biology

Volume: 7, P: 1-9
Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining

Microbial genomes encode enzymes for biosynthesis of many uncharacterized peptides. Here, the authors screen over 7,300 bacterial genomes for potential biosynthesis of cationic non-ribosomal peptides, and identify two novel peptides with activities against antibiotic-resistant Gram-negative pathogens.

Yong-Xin Li
Zheng Zhong
Pei-Yuan Qian
ResearchOpen Access16 Aug 2018
Nature Communications

Volume: 9, P: 1-9
Resistance to nonribosomal peptide antibiotics mediated by d-stereospecific peptidases

Networking-associated genome mining on bacterial genomes followed by chemical and enzymatic analysis identified a mechanism of resistance toward nonribosomal peptide antibiotics based on hydrolytic cleavage by d-stereospecific peptidases.

Yong-Xin Li
Zheng Zhong
Pei-Yuan Qian
Research26 Feb 2018
Nature Chemical Biology

Volume: 14, P: 381-387
Marine biofilms: diversity, interactions and biofouling

Marine biofilms grow on diverse marine surfaces, ranging from particles to animals and ships. In this Review, Qian and colleagues discuss the diversity and composition of marine biofilms and their role in the development of marine benthos and biofouling.

Pei-Yuan Qian
Aifang Cheng
Rui Zhang
Reviews25 May 2022
Nature Reviews Microbiology

Volume: 20, P: 671-684
Evidence for the dynamics of Acyl homoserine lactone and AHL-producing bacteria during subtidal biofilm formation

Yi-Li Huang
Jang-Seu Ki
Pei-Yuan Qian
Research06 Nov 2008
The ISME Journal

Volume: 3, P: 296-304
Proteomic analyses reveal the key role of gene co-option in the evolution of the scaly-foot snail scleritome

A proteomics-led study on the sclerite formation of scaly-foot snails suggests that gene co-option was the dominant event contributing to evolution of this process, while the formation process of the long-existing spiral shell likely incorporated relatively younger genes.

Wai Chuen Wong
Yick Hang Kwan
Jin Sun
ResearchOpen Access28 Feb 2025
Communications Biology

Volume: 8, P: 1-13
Delta-proteobacterial SAR324 group in hydrothermal plumes on the South Mid-Atlantic Ridge

Huiluo Cao
Chunming Dong
Pei-Yuan Qian
ResearchOpen Access08 Mar 2016
Scientific Reports

Volume: 6, P: 1-9
Transcriptome analysis elucidates key developmental components of bryozoan lophophore development

Yue Him Wong
Taewoo Ryu
Timothy Ravasi
ResearchOpen Access10 Oct 2014
Scientific Reports

Volume: 4, P: 1-10
Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin

Variations in pathway off-loading and module skipping within a hybrid polyketide synthase–nonribosomal peptide synthetase lead to the production of a collection of precursors to colibactin, a genotoxic compound produced by gut bacteria.

Zhong-Rui Li
Jie Li
Pei-Yuan Qian
Research22 Aug 2016
Nature Chemical Biology

Volume: 12, P: 773-775
Indole alkaloids from marine-derived fungus Aspergillus sydowii SCSIO 00305

Fei He
Yu-Lin Sun
Shu-Hua Qi
Research21 Dec 2011
The Journal of Antibiotics

Volume: 65, P: 109-111
Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp. SCSGAF 0023

Jie Bao
Yu-Lin Sun
Shu-Hua Qi
Research12 Dec 2012
The Journal of Antibiotics

Volume: 66, P: 219-223
Hydrothermally generated aromatic compounds are consumed by bacteria colonizing in Atlantis II Deep of the Red Sea

Yong Wang
Jiangke Yang
Pei-Yuan Qian
Research28 Apr 2011
The ISME Journal

Volume: 5, P: 1652-1659
Erratum: Vertical stratification of microbial communities in the Red Sea revealed by 16S rDNA pyrosequencing

Pei-Yuan Qian
Yong Wang
Tim Y H Wong
Amendments and Corrections15 Feb 2011
The ISME Journal

Volume: 5, P: 568
Pyrosequencing reveals highly diverse and species-specific microbial communities in sponges from the Red Sea

On On Lee
Yong Wang
Pei-Yuan Qian
Research18 Nov 2010
The ISME Journal

Volume: 5, P: 650-664
Genomic and transcriptomic insights into complex virus–prokaryote interactions in marine biofilms

Kun Zhou
Tin Yan Wong
Pei-Yuan Qian
ResearchOpen Access24 Oct 2023
The ISME Journal

Volume: 17, P: 2303-2312
Species sorting during biofilm assembly by artificial substrates deployed in a cold seep system

Wei Peng Zhang
Yong Wang
Pei-Yuan Qian
ResearchOpen Access17 Oct 2014
Scientific Reports

Volume: 4, P: 1-7
Autotrophic Microbe Metagenomes and Metabolic Pathways Differentiate Adjacent Red Sea Brine Pools

Yong Wang
Huiluo Cao
Pei-Yuan Qian
ResearchOpen Access29 Apr 2013
Scientific Reports

Volume: 3, P: 1-11
Proteomic Changes Associated with Successive Reproductive Periods in Male Polychaetous Neanthes arenaceodentata

Kondethimmanahalli H. Chandramouli
Donald Reish
Timothy Ravasi
ResearchOpen Access04 Sept 2015
Scientific Reports

Volume: 5, P: 1-10
Secretory locations of SIPC in Amphibalanus amphitrite cyprids and a novel function of SIPC in biomineralization

Gen Zhang
Xiao-Xue Yang
Pei-Yuan Qian
ResearchOpen Access20 Jul 2016
Scientific Reports

Volume: 6, P: 1-11
In situ environment rather than substrate type dictates microbial community structure of biofilms in a cold seep system

On On Lee
Yong Wang
Pei-Yuan Qian
ResearchOpen Access08 Jan 2014
Scientific Reports

Volume: 4, P: 1-10
Temperature shapes coral-algal symbiosis in the South China Sea

Haoya Tong
Lin Cai
Pei-Yuan Qian
ResearchOpen Access13 Jan 2017
Scientific Reports

Volume: 7, P: 1-12
Vertical stratification of microbial communities in the Red Sea revealed by 16S rDNA pyrosequencing

Pei-Yuan Qian
Yong Wang
Tim YH Wong
Research29 Jul 2010
The ISME Journal

Volume: 5, P: 507-518
Endosymbiont population genomics sheds light on transmission mode, partner specificity, and stability of the scaly-foot snail holobiont

Yi Lan
Jin Sun
Pei-Yuan Qian
ResearchOpen Access17 Jun 2022
The ISME Journal

Volume: 16, P: 2132-2143
Horseshoe crab genomes reveal the evolution of genes and microRNAs after three rounds of whole genome duplication

Wenyan Nong, Zhe Qu, Yiqian Li, Tom Barton-Owen, Annette Wong and colleagues provide genomes and small RNA transcriptomes for the mangrove horseshoe crab and the tri-spine horseshoe crab. They show that horseshoe crabs have undergone three rounds of whole genome duplication and shed light on how gene families and microRNAS evolved following this genome duplication event.

Wenyan Nong
Zhe Qu
Jerome H. L. Hui
ResearchOpen Access19 Jan 2021
Communications Biology

Volume: 4, P: 1-11
Pregnancy Outcomes in Women of Advanced Maternal Age: a Retrospective Cohort Study from China

Dan Shan
Pei-Yuan Qiu
Ya-Yi Hu
ResearchOpen Access16 Aug 2018
Scientific Reports

Volume: 8, P: 1-9
Genomic, transcriptomic, and proteomic insights into the symbiosis of deep-sea tubeworm holobionts

Yi Yang
Jin Sun
Pei-Yuan Qian
ResearchOpen Access08 Oct 2019
The ISME Journal

Volume: 14, P: 135-150
Exploring coral microbiome assemblages in the South China Sea

Lin Cai
Ren-Mao Tian
Pei-Yuan Qian
ResearchOpen Access05 Feb 2018
Scientific Reports

Volume: 8, P: 1-13
Proteomic response of methicillin-resistant S. aureus to a synergistic antibacterial drug combination: a novel erythromycin derivative and oxacillin

Xiaofen Liu
Pei-Jin Pai
Henry Lam
ResearchOpen Access25 Jan 2016
Scientific Reports

Volume: 6, P: 1-12
Directed natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilis

Yongxin Li
Zhongrui Li
Pei-Yuan Qian
ResearchOpen Access24 Mar 2015
Scientific Reports

Volume: 5, P: 1-7
Metagenomic analysis reveals a green sulfur bacterium as a potential coral symbiont

Lin Cai
Guowei Zhou
Pei-Yuan Qian
ResearchOpen Access24 Aug 2017
Scientific Reports

Volume: 7, P: 1-11
Adaptation and evolution of deep-sea scale worms (Annelida: Polynoidae): insights from transcriptome comparison with a shallow-water species

Yanjie Zhang
Jin Sun
Jian-Wen Qiu
ResearchOpen Access11 Apr 2017
Scientific Reports

Volume: 7, P: 1-14
p38 MAPK regulates PKAα and CUB-serine protease in Amphibalanus amphitrite cyprids

Gen Zhang
Li-Sheng He
Pei-Yuan Qian
ResearchOpen Access05 Oct 2015
Scientific Reports

Volume: 5, P: 1-14
High-throughput transcriptome sequencing of the cold seep mussel Bathymodiolus platifrons

Yue Him Wong
Jin Sun
Pei-Yuan Qian
ResearchOpen Access23 Nov 2015
Scientific Reports

Volume: 5, P: 1-15
Mechanism of Action of Thalassospiramides, A New Class of Calpain Inhibitors

Liang Lu
Michael J. Meehan
Pei-Yuan Qian
ResearchOpen Access05 Mar 2015
Scientific Reports

Volume: 5, P: 1-8

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