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Emergent quantum phenomena such as quantized anomalous Hall effect may be realized in magnetic topological materials. Here, Hu et al. discovered an intrinsic natural heterostructural Z₂ antiferromagnetic topological insulator MnBi₄Te₇ with low out-of-plane saturation fields.

Lipid nanoparticles (LNPs) are effective vehicles to deliver mRNA vaccines and therapeutics but assessing the mRNA packaging characteristics in LNPs is challenging. Here, the authors report that mRNA and lipid contents in LNP formulations can be quantitatively examined by multi-laser cylindrical illumination confocal spectroscopy at the single-nanoparticle level.

Eutrophication has been shown to weaken diversity-stability relationships in grasslands, but it is unclear whether the effect depends on scale. Analysing a globally distributed network of grassland sites, the authors show a positive role of beta diversity and spatial asynchrony as drivers of stability but find that nitrogen enrichment weakens the diversity-stability relationships at different spatial scales.

Nipah virus is a WHO priority pathogen, and there is currently no approved drug for clinical therapy. Here, the authors identified potent human neutralizing antibodies that block receptor binding and provide protection against NiV infection in vivo.

The direct and facile growth of WS₂ and WSe₂ nanotubes with controllable chirality is realized using catalytic chemical vapour deposition with Au nanoparticles.

Recent studies have reported the exceptional plasticity of InSe van der Waals crystals, but their deformation-correlated lattice dynamics remains unexplored. Here, the authors investigate the correlations of plastic interlayer slip, lattice anharmonicity and thermal transport in β-InSe crystals via neutron scattering techniques.

Large language models promise substantial advances in molecular modelling and design. A multimodal benchmark is proposed to analyse performance, and 1,263 experiments are conducted to examine the compatibility of a large language model with data modalities and knowledge acquisition.

Atomically dispersed metal catalysts are of increasing importance in many catalytic processes, but clear structural identification is challenging. Here, a general synthesis of metal (nickel, iron and cobalt) single-atom catalysts on nitrogen-doped graphene allows the authors to identify a common structure and furthermore correlate structure with electrocatalytic activity.

Single-cell photoacoustic microscopy can perform high-throughput measurements of intratumoral metabolic heterogeneity in specimens from patients with breast cancer.

The effects of expanding electric vehicle charging stations on housing values are unknown. This study fills the gap with data for California and finds that properties near charging stations show a higher price, while traffic slightly increases and particulate matter (PM_2.5) emissions decrease.

Polariton chemistry, namely the coupling of molecular vibrations to quantized radiation modes inside an optical microcavity, offers a promising strategy to modify chemical reactivities. Here, the authors provide a comprehensive theory of how vibrational strong coupling modifies chemical reaction rates in different cavity regimes.

Previous studies on high harmonic generation from molecules have been used to identify the spectral properties and orbital contributions. Here the authors measure the isotopic effects in the energy shift of the HHG spectra caused by the nuclear motion of the molecules.

The Valencia Trough and the Algerian Sea Basin in the Western Mediterranean formed simultaneously due to the rotational rollback of the Gibraltar slab, a study using numerical geodynamic models reveals.

The hydroxyl radical is generated during radiotherapy and ferroptosis and accurate imaging of this reactive oxygen species may permit the monitoring of response to therapy. Here, the authors develop a ratiometric probe for accurate imaging of hydroxyl radical generation in vivo.

The working mechanism of several low-cost electrocatalyst materials is still arguable. Here the authors show a model Fe,Mn/N-C catalyst where the oxygen reduction preferentially takes place on Fe(III) sites with the intermediate spin state (t2g4 eg1) caused by the adjacent Mn-N moieties.

Here, the authors fabricate large area and highly aligned polymer semiconductor sub-microwires arrays via coaxial focused electrohydrodynamic jet printing technology, achieving high on/off ratio and average mobility that is 5x higher than that of thin film based organic field effect transistors.

Single-atom catalysts demonstrate enhanced catalytic properties, but most systems only explore combinations of a few different metals. Here, a library of 37 different elements is investigated, and it is shown that loading 12 metallic atoms in one system presents improved electrochemical activity.

Protein identification at the single-molecule level is the ultimate goal for biological research and disease diagnosis. Here, the authors identify the size, charge, mobility, and binding of individual protein molecules by measuring the optical and electrical responses of each protein molecule tethered to a surface.

The development of future Na metal batteries relies on the cycling stability of the metallic anode. Here, the authors propose a polypropylene separator functionalized with polydopamine and multilayer graphene to enable stable and prolonged Na metal cell cycling.

Multivalent nanobodies against SARS-CoV-2 from mice engineered to produce camelid nanobodies recognize conserved epitopes that are inaccessible to human antibodies and show promise as a strategy for dealing with viral escape mutations.

The stability of granular assemblies depends on particle shape, but clear laws governing key properties like contact number and friction coefficient remain elusive. Using X-ray tomography and simulations, the authors uncover linear scaling laws linking shape to these properties, showing that the scaling of contact number persists at a lower sphericity than that for the apparent friction coefficient, and that elongation increases contact numbers but does not significantly enhance stability.

The effects of novel antibodies are hard to predict owing to the complex interactions between antibodies and antigens. Zhang and colleagues use a graph-based method to learn a dynamic representation that allows for predictions of neutralization activity and demonstrate the method by recommending probable antibodies for human immunodeficiency virus, severe acute respiratory syndrome coronavirus 2, influenza and dengue.

Electrocatalytic water splitting for hydrogen and oxygen generation provides an attractive path to obtain clean energy, but the half reaction of oxygen evolution remains the bottleneck for the progress. Here, the authors show single atom tungsten doped ultrathin α-Ni(OH)₂ exhibits enhanced performance in electrocatalytic water oxidation.

The 1T′ phase of MoS₂ monolayers, as well as the 2H phase and their heterophase bilayers, can be grown directly by tuning the potassium concentration in the reaction atmosphere. The pure 1T′ phase demonstrates in-plane anisotropic properties.

Indicine cattle make up half of all cattle populations worldwide. Using a large genomic dataset, this study finds historic migrations and extensive introgression with domestic and wild bovine species has facilitated this species physiological adaptation to extreme environments.

The ability of animals to respond to life-threatening stimuli is critical for survival, yet the neural circuits mediating innate defensive behaviors are not well understood. Here, the authors reveal a novel collicular–thalamic–amygdala circuit critical for innate defensive responses to visual threats.

Extending qubit coherence times represent one of the key challenges for quantum technologies. Here, after properly suppressing magnetic-field fluctuations, frequency instability and leakage of the microwave reference-oscillator, the authors infer coherence times of 5500 s for an Yb ion qubit.

Designing ultra small metal nanoclusters or single atoms with metallic state is a challenge. Here, the authors demonstrate the stabilization of ultra small silver clusters in the nearly-metallic state by oxygen adsorption at high temperature, using in situ spectroscopy and microscope technologies.

Aquatic ecological network stability of the plankton community declined substantially in the mid-1990s in response to climate warming and nutrient enrichment, according to a sedimentary DNA analysis in Lake Chagan, China coupled with planktonic network models.

The SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme provides a real-time risk assessment of SARS-CoV-2 variants with the potential to affect transmission, virulence and resistance to infection- and vaccine-induced immunity.

In a new study Yingxian Li and her colleagues show that the microRNA miR-214 targets ATF4 in osteoblasts to negatively regulate their activity. Manipulating miR-214 levels experimentally showed that its elevated expression is sufficient to induce bone loss in mice and that its therapeutic inhibition reduces bone loss in two mouse models.

Detection ofde novo, low frequency mutations is important for characterising heterogeneous cell populations, such as those found in cancer cell populations. Here the authors present o2n-seq, an ultrasensitive method with highly efficient data usage for detection of rare mutations.

The combination of nonlinearity and topology has recently attracted significant attention in the field of optical physics. This work considers a photonic Chern insulator in the nonlinear regime and explores the properties of topological bulk solitons holding the stability and robustness, which contributes to the field of nonlinear topological photonics and provides further physical understandings towards other photonic topological insulators with nonlinearity.