Nature Search

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
High-throughput mutagenesis reveals unique structural features of human ADAR1

Human ADAR proteins are responsible for RNA editing, conversion of adenosine to inosine in double-stranded RNA. Here the authors report a previously unknown zinc ion-binding site in the catalytic domain of human ADAR1 using high throughput mutagenesis, biochemical assay and Rosetta-based protein structure modeling.

SeHee Park
Erin E. Doherty
Peter A. Beal
ResearchOpen Access12 Oct 2020
Nature Communications

Volume: 11, P: 1-13
A microRNA-based dynamic risk score for type 1 diabetes

A 50 microRNA-based dynamic risk score for stratifying individuals with and without type 1 diabetes was developed using samples obtained from multicenter and multiethnic cohorts.

Mugdha V. Joglekar
Wilson K. M. Wong
Noha Lim
ResearchOpen Access05 Jun 2025
Nature Medicine

Volume: 31, P: 2622-2631
Quantifying the local adaptive landscape of a nascent bacterial community

Fitness landscapes largely shape the dynamics of evolution, but it is unclear how they shift upon ecological diversification. By engineering genome-wide knockout libraries of a nascent bacterial community, Ascensao et al. show how ecological and epistatic patterns combine to shape adaptive landscapes.

Joao A. Ascensao
Kelly M. Wetmore
Oskar Hallatschek
ResearchOpen Access16 Jan 2023
Nature Communications

Volume: 14, P: 1-19
Lateral diffusion of lipids in sarcoplasmic reticulum membranes is area limited

Peter Laggner
Research26 Nov 1981
Nature

Volume: 294, P: 373-374
Antibody and HIV-1 gpl20 recognition of CD4 undermines the concept of mimicry between antibodies and receptors

Simon J. Davis
Gérard A. Schockmel
Alan F. Williams
Research02 Jul 1992
Nature

Volume: 358, P: 76-79
Insights from the Biorepository and Integrative Genomics pediatric resource

Genomic studies often lack representation from diverse populations, limiting equitable insights. Here, the authors show that the BIG Initiative captures extensive genetic diversity and reveals ancestry-linked health disparities in a community-based Mid-South cohort.

Silvia Buonaiuto
Franco Marsico
Vincenza Colonna
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-12
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets

Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but establish good ligandability of ATG8 isoforms through fragment screening and docking.

Martin P. Schwalm
Johannes Dopfer
Vladimir V. Rogov
ResearchOpen Access25 Nov 2024
Nature Communications

Volume: 15, P: 1-15
Cameral liquid transport and buoyancy control in chambered nautilus (Nautilus macromphalus)

Lewis Greenwald
Peter D. Ward
O. E. Greenwald
Research03 Jul 1980
Nature

Volume: 286, P: 55-56
Sequence and functional expression of the GABA_A receptor shows a ligand-gated receptor super-family

Peter R. Schofield
Mark G. Darlison
Eric A. Barnard
Research16 Jul 1987
Nature

Volume: 328, P: 221-227
The role of interleukin–15 in T–cell migration and activation in rheumatoid arthritis

Iain B. McInnes
Jamil Al-Mughales
Foo Y. Liew
Research01 Feb 1996
Nature Medicine

Volume: 2, P: 175-182
RNA methyltransferase SPOUT1/CENP-32 links mitotic spindle organization with the neurodevelopmental disorder SpADMiSS

The RNA methyltransferase activity of SPOUT1/CENP-32 is crucial for accurate mitotic spindle organization. Here, the authors describe a neurodevelopmental disorder caused by bi-allelic pathogenic SPOUT1 variants with reduced activity and compromised function in spindle organization.

Avinash V. Dharmadhikari
Maria Alba Abad
Jun Liao
ResearchOpen Access17 Feb 2025
Nature Communications

Volume: 16, P: 1-24
In vitro osteoclast generation from different bone marrow fractions, including a highly enriched haematopoietic stem cell population

Ben A. A. Scheven
Jan W. M. Visser
Peter J. Nijweide
Research01 May 1986
Nature

Volume: 321, P: 79-81
Robust encoding of natural stimuli by neuronal response sequences in monkey visual cortex

How the brain analyzes complex visual scenes within a fraction of a second remains poorly understood. Here, the authors suggest that this might be accomplished through the use of a temporal code by exploiting the sequence order of responses generated in networks of recurrently coupled neurons that harbor the priors of natural image statistics.

Yang Yiling
Katharine Shapcott
Wolf Singer
ResearchOpen Access25 May 2023
Nature Communications

Volume: 14, P: 1-18
Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration

Loss-of-function variants in thyroid hormone transporter MCT8 cause a neurodevelopmental and metabolic disorder. Here the authors identify genotype-phenotype relationships, advance insights in MCT8 (dys)function and create a pathogenicity-severity variant classifier.

Stefan Groeneweg
Ferdy S. van Geest
W. Edward Visser
ResearchOpen Access12 Mar 2025
Nature Communications

Volume: 16, P: 1-21
Distinct non-canonical translation initiation modes arise for specific host and viral mRNAs during poxvirus-induced shutoff

During poxvirus-induced shutoff, certain cellular and viral mRNAs continue to be translated through distinct modes of non-canonical initiation, in part due to altered ribosome activity, to produce host and viral proteins that support virus spread.

Chorong Park
Aaron J. Ferrell
Derek Walsh
Research28 May 2025
Nature Microbiology

Volume: 10, P: 1535-1549
Polymorphism in the α₃ domain of HLA-A molecules affects binding to CD8

Russell D. Salter
Anne M. Norment
Peter Parham
Research23 Mar 1989
Nature

Volume: 338, P: 345-347
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

Shi Du Yan
Xi Chen
Ann Marie Schmidt
Research22 Aug 1996
Nature

Volume: 382, P: 685-691
Cloning and sequence analysis of cDNAs encoding two distinct somatostatin precursors found in the endocrine pancreas of anglerfish

Peter Hobart
Robert Crawford
William J. Rutter
Research13 Nov 1980
Nature

Volume: 288, P: 137-141
Birth of the D-E-A-D box

PATRICK LINDER
PAUL F. LASKO
PIOTR P. SLONIMSKI
Research12 Jan 1989
Nature

Volume: 337, P: 121-122
Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex

Peter van den Elsen
Beth-Ann Shepley
Cox Terhorst
Research29 Nov 1984
Nature

Volume: 312, P: 413-418
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Genome-wide analyses identify common variants associated with 11 distinct neuropathology endophenotypes, providing insights into the mechanisms underlying the genetic risk of Alzheimer’s disease and related dementias.

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
ResearchOpen Access08 Oct 2024
Nature Genetics

Volume: 56, P: 2407-2421
Genomics of a sexually selected sperm ornament and female preference in Drosophila

A comparative analysis of morphological data across 149 species of Drosophilidae shows that sperm length in males has co-evolved with the length of the sperm-storage organ in females. Combining a genome-wide association study of these traits in Drosophila melanogaster with molecular evolutionary analyses of the genomes of 15 Drosophila species, the authors find that the genetic architecture underlying sperm length is associated with indirect genetic benefits in females, providing support for the ‘good genes’ hypothesis.

Zeeshan A. Syed
R. Antonio Gomez
Scott Pitnick
Research22 Nov 2024
Nature Ecology & Evolution

Volume: 9, P: 336-348
Burdens of type 2 diabetes and cardiovascular disease attributable to sugar-sweetened beverages in 184 countries

Estimates from the Global Dietary Database indicated that 2.2 million new type 2 diabetes and 1.2 million new cardiovascular disease cases were attributable to sugar-sweetened beverages worldwide in 2020, with the highest burdens in sub-Saharan Africa, Latin America and the Caribbean.

Laura Lara-Castor
Meghan O’Hearn
Rubina Hakeem
ResearchOpen Access06 Jan 2025
Nature Medicine

Volume: 31, P: 552-564
HLA-A and B polymorphisms predate the divergence of humans and chimpanzees

David A. Lawlor
Frances E. Ward
Peter Parham
Research15 Sept 1988
Nature

Volume: 335, P: 268-271
A systematic review of income and education reporting in psychedelic clinical trials

This systematic review analyzes how income and educational attainment are reported in psychedelic-assisted therapy trials. It reveals that only a minority of trials report this information and, when reported, the data have considerable variation in format and ambiguity in details. It also reveals disparities, with participants having higher income and being highly educated overrepresented in trials.

Daniel H. Grossman
Kevin R. Madden
Peter S. Hendricks
Research12 May 2025
Nature Mental Health

Volume: 3, P: 567-574
The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

Paul Dent
Alain Lavoinne
Philip Cohen
Research22 Nov 1990
Nature

Volume: 348, P: 302-308
Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus

Barbara Levinson
George Khoury
Peter Gruss
Research18 Feb 1982
Nature

Volume: 295, P: 568-572
Identification of genetic elements in metabolism by high-throughput mouse phenotyping

The genetic basis of metabolic diseases is incompletely understood. Here, by high-throughput phenotyping of 2,016 knockout mouse strains, Rozman and colleagues identify candidate metabolic genes, many of which are associated with unexplored regulatory gene networks and metabolic traits in human GWAS.

Jan Rozman
Birgit Rathkolb
Martin Hrabe de Angelis
ResearchOpen Access18 Jan 2018
Nature Communications

Volume: 9, P: 1-16
Compensation of ocean acidification effects in Arctic phytoplankton assemblages

The effects of projected ocean acidification on primary productivity of the Arctic and subarctic shelf seas are found to be minimal, with the phytoplankton communities showing a high capacity to compensate for environmental change.

Clara Jule Marie Hoppe
Klara K. E. Wolf
Björn Rost
Research30 Apr 2018
Nature Climate Change

Volume: 8, P: 529-533
The molecular structure and stability of the eye lens: X-ray analysis of γ-crystallin II

Tom Blundell
Peter Lindley
Graeme Wistow
Research26 Feb 1981
Nature

Volume: 289, P: 771-777
Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results

An individualized, heterologous chimpanzee adenovirus (ChAd68) and self-amplifying mRNA-based neoantigen vaccine is safe and well tolerated in patients, warranting further studies to test its potential to rescue response to checkpoint blockade in tumors of low immune reactivity.

Christine D. Palmer
Amy R. Rappaport
Karin Jooss
Research15 Aug 2022
Nature Medicine

Volume: 28, P: 1619-1629
Evidence for disequilibrium of ortho and para hydrogen on Jupiter from Voyager IRIS measurements

Barney J. Conrath
Peter J. Gierasch
Research08 Dec 1983
Nature

Volume: 306, P: 571-572
Exploitation, secondary extinction and the altered trophic structure of Jamaican coral reefs

Peter Roopnarine
Rachel Hertog
ResearchOpen Access01 Feb 2010
Nature Precedings

P: 1
Human de novo mutation rates from a four-generation pedigree reference

Analysis of more than 95% of each diploid human genome of a four-generation, twenty-eight-member family using five complementary short-read and long-read sequencing technologies provides a truth set to understand the most fundamental processes underlying human genetic variation.

David Porubsky
Harriet Dashnow
Evan E. Eichler
ResearchOpen Access23 Apr 2025
Nature

Volume: 643, P: 427-436
Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

Peter J. Peters
Jacques J. Neefjes
Hans J. Geuze
Research21 Feb 1991
Nature

Volume: 349, P: 669-676
The yeast transposon Ty1 generates duplications of target DNA on insertion

Jürg Gafner
Peter Philippsen
Research24 Jul 1980
Nature

Volume: 286, P: 414-418
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

Jie Shen
Wander Valentim
Gita A. Pathak
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

The full extent of the genetic basis for hearing impairment is unknown. Here, as part of the International Mouse Phenotyping Consortium, the authors perform a hearing loss screen in 3006 mouse knockout strains and identify 52 new candidate genes for genetic hearing loss.

Michael R. Bowl
Michelle M. Simon
Steve D. M. Brown
ResearchOpen Access12 Oct 2017
Nature Communications

Volume: 8, P: 1-11
Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene

John P. McGrath
Daniel J. Capon
Arthur D. Levinson
Research11 Aug 1983
Nature

Volume: 304, P: 501-506
Some population genetic models combining sexual selection with assortative mating

Samuel Karlin
Peter O'Donald
Research01 Oct 1978
Heredity

Volume: 41, P: 165-174
Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

Daniel J. Capon
Ellson Y. Chen
David V. Goeddel
Research03 Mar 1983
Nature

Volume: 302, P: 33-37
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

A multi-ancestry genome-wide association study meta-analysis, combined with transcriptome- and methylome-wide association analyses, identifies risk loci associated with colorectal cancer. Credible effector genes and their target tissues are also highlighted, showing that over a third probably act outside the colonic mucosa.

Ceres Fernandez-Rozadilla
Maria Timofeeva
Ulrike Peters
Research20 Dec 2022
Nature Genetics

Volume: 55, P: 89-99
HIV-1 tropism and co-receptor use

Matthias T. Dittmar
Áine McKnight
Peter Simmonds
Research06 Feb 1997
Nature

Volume: 385, P: 495-496
Towards complete and error-free genome assemblies of all vertebrate species

The Vertebrate Genome Project has used an optimized pipeline to generate high-quality genome assemblies for sixteen species (representing all major vertebrate classes), which have led to new biological insights.

Arang Rhie
Shane A. McCarthy
Erich D. Jarvis
ResearchOpen Access28 Apr 2021
Nature

Volume: 592, P: 737-746
Author Correction: Butler enables rapid cloud-based analysis of thousands of human genomes

Sergei Yakneen
Sebastian M. Waszak
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Biotechnology

Volume: 41, P: 577
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Joshua S. Weinstock
Jayakrishnan Gopakumar
Siddhartha Jaiswal
Research12 Apr 2023
Nature

Volume: 616, P: 755-763
Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Esther Rheinbay
Morten Muhlig Nielsen
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E40
Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse

Paul M. Brickell
David S. Latchman
Peter W. J. Rigby
Research22 Dec 1983
Nature

Volume: 306, P: 756-760
Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11

Allan Peter Davis
David P. Witte
Mario R. Capecchi
Research29 Jun 1995
Nature

Volume: 375, P: 791-795

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